在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LARP6 Antibody, HRP conjugated

  • 中文名稱:
    LARP6兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA887112LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LARP6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LARP6
  • 別名:
    Acheron antibody; Achn antibody; FLJ11196 antibody; La ribonucleoprotein domain family member 6 antibody; La-related protein 6 antibody; LARP6 antibody; LARP6_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human La-related protein 6 protein (294-453AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
  • 基因功能參考文獻:
    1. Study shows that mTORC1 phosphorylates La ribonucleoprotein domain family, member 6 to stimulate type I collagen expression. PMID: 28112218
    2. A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA. PMID: 28782243
    3. Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen PMID: 26932461
    4. We postulate that collagen mRNAs directly partition to the endoplasmic reticulum membrane prior to synthesis of the signal peptide and that LARP6 and nonmuscle myosin filaments mediate this process. PMID: 25271881
    5. Data indicate that LA motif protein LARP6 binding to spliced leader RNA (5'SL) of collagen alpha2(I) mRNA is more stable than the binding to 5'SL of alpha1(I) mRNA. PMID: 25692237
    6. The study presents the structure of the La motif and RRM1 of human LARP6 uncovering in both cases considerable structural variation in comparison to the equivalent domains in La and revealing an unprecedented fold for the RRM1. PMID: 25488812
    7. LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle PMID: 24469459
    8. The results demonstrate that the La modules of the human LARP6 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection. PMID: 23887937
    9. Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing. PMID: 22139627
    10. Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization. PMID: 21387291
    11. LARP6 has a distinctive bipartite RNA binding domain not found in other members of the La superfamily. LARP6 interacts with the two single-stranded regions of the 5' stem-loop. PMID: 19917293
    12. Acheron may influence differentiation in part via its control of cell adhesion dynamics. PMID: 19889961
    13. These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals. PMID: 17383118

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
  • 組織特異性:
    Expressed in numerous tissues.
  • 數據庫鏈接:

    HGNC: 24012

    OMIM: 611300

    KEGG: hsa:55323

    STRING: 9606.ENSP00000299213

    UniGene: Hs.416755



主站蜘蛛池模板: 欧美午夜片欧美片在线观看| 99久久人妻无码精品系列| 夜夜爽夜夜叫夜夜高潮漏水 | 奶真大水真多小荡货av| 国产精品欧美久久久久无广告| 极品新婚夜少妇真紧| 国产亚洲精品久久久网站好莱| 国产精品沙发系列| 国产精品真实灌醉女在线播放| 无码日韩精品一区二区免费暖暖| 18禁高潮出水呻吟娇喘蜜芽| 男人女人午夜视频免费| 伊人成伊人成综合网222| 人妻少妇熟女javhd| 绝顶丰满少妇av无码| 99er国产这里只有精品视频免费| 西西艺术人像摄影| 一个添下面两个吃奶把腿扒开| 国内精品伊人久久久久777| 国产精品久久综合免费| av无码av在线a∨天堂app| 久久人人爽人人爽人人片av不 | av网站免费线看精品| 国产乱人伦av在线麻豆a| 亚洲乱码一区二区三区在线观看| 亚洲日本中文字幕天天更新| 婷婷俺也去俺也去官网| 884aa四虎影成人精品| 精品无码国产av一区二区| 精品亚洲国产成人a片app| 亚洲精品国产成人精品软件| 波多野美乳人妻hd电影欧美| 日躁夜躁狠狠躁2001| 成人午夜无码精品免费看| 中文字幕被公侵犯的漂亮人妻| 欧美熟妇xxxxx欧美老妇不卡 | 又爽又黄无遮挡高潮视频网站| 国产成年无码v片在线| 美女张开腿让人桶| 欧美 在线 成 人怡红院| 国产精品亚洲综合一区二区三区|