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  4. Recombinant Human LYR motif-containing protein 4 (LYRM4)

Recombinant Human LYR motif-containing protein 4 (LYRM4)

  • 中文名稱：
    人LYRM4重組蛋白
  • 貨號：
    CSB-YP875729HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LYRM4重組蛋白
  • 貨號：
    CSB-EP875729HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LYRM4重組蛋白
  • 貨號：
    CSB-EP875729HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LYRM4重組蛋白
  • 貨號：
    CSB-BP875729HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LYRM4重組蛋白
  • 貨號：
    CSB-MP875729HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LYRM4
  • Uniprot No.：
  • 別名：
    BC034664; C6orf149; CGI 203; Chromosome 6 open reading frame 149; Gm903; Homolog of yeast Isd11; ISD11; LYR motif containing 4; LYR motif-containing protein 4; LYRM4; LYRM4_HUMAN; MGC38622; Mitochondrial matrix Nfs1 interacting protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-91
  • 氨基酸序列
    MAASSRAQVL SLYRAMLRES KRFSAYNYRT YAVRRIRDAF RENKNVKDPV EIQTLVNKAK RDLGVIRRQV HIGQLYSTDK LIIENRDMPR T
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.
  • 基因功能參考文獻：
    1. analysis of the NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters PMID: 28634302
    2. Human Isd11 (ISD11) is a helical protein which exists in solution as an equilibrium between monomer, dimeric and tetrameric species when in the absence of human Nfs1 (NFS1). Recombinant ISD11 expressed in E. coli co-purifies with the bacterial orthologue of NFS1, IscS. PMID: 27427956
    3. The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for Fe-S cluster formation. PMID: 28271877
    4. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN(42-210)]24.[NFS1]24.[ISD11]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components. PMID: 27519411
    5. Our findings highlight that the ISD11 R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1 aggregation resulting in impairment of the Fe-S cluster biogenesis PMID: 26342079
    6. Homozygous mutation in LYRM4 was reported in two patients with combined oxidative phosphorylation deficiency. PMID: 23814038
    7. LYRM4 downregulation may be one of the mechanisms involved in inefficient oxidative phosphorylation and oxidative stress, increasingly recognised as contributors to schizophrenia pathogenesis. PMID: 21968932
    8. Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients PMID: 22277967
    9. Frataxin interacts with ISD11 and multiple mitochondrial chaperones. PMID: 17331979
    10. ISD11 is important in the biogenesis of Fe-S clusters in mammalian cells. PMID: 19454487

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  • 相關疾病：
    Combined oxidative phosphorylation deficiency 19 (COXPD19)
  • 亞細胞定位：
    Mitochondrion. Nucleus.
  • 蛋白家族：
    Complex I LYR family
  • 組織特異性：
    Reduced mRNA levels in Friedreich ataxia patients.
  • 數據庫鏈接：

    HGNC: 21365

    OMIM: 613311

    KEGG: hsa:57128

    STRING: 9606.ENSP00000443900

    UniGene: Hs.387755



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