在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LYRM4 Antibody, FITC conjugated

  • 中文名稱:
    LYRM4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA875729LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LYRM4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LYRM4
  • 別名:
    BC034664 antibody; C6orf149 antibody; CGI 203 antibody; Chromosome 6 open reading frame 149 antibody; Gm903 antibody; Homolog of yeast Isd11 antibody; ISD11 antibody; LYR motif containing 4 antibody; LYR motif-containing protein 4 antibody; LYRM4 antibody; LYRM4_HUMAN antibody; MGC38622 antibody; Mitochondrial matrix Nfs1 interacting protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human LYR motif-containing protein 4 protein (1-91AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.
  • 基因功能參考文獻:
    1. analysis of the NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters PMID: 28634302
    2. Human Isd11 (ISD11) is a helical protein which exists in solution as an equilibrium between monomer, dimeric and tetrameric species when in the absence of human Nfs1 (NFS1). Recombinant ISD11 expressed in E. coli co-purifies with the bacterial orthologue of NFS1, IscS. PMID: 27427956
    3. The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for Fe-S cluster formation. PMID: 28271877
    4. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN(42-210)]24.[NFS1]24.[ISD11]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components. PMID: 27519411
    5. Our findings highlight that the ISD11 R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1 aggregation resulting in impairment of the Fe-S cluster biogenesis PMID: 26342079
    6. Homozygous mutation in LYRM4 was reported in two patients with combined oxidative phosphorylation deficiency. PMID: 23814038
    7. LYRM4 downregulation may be one of the mechanisms involved in inefficient oxidative phosphorylation and oxidative stress, increasingly recognised as contributors to schizophrenia pathogenesis. PMID: 21968932
    8. Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients PMID: 22277967
    9. Frataxin interacts with ISD11 and multiple mitochondrial chaperones. PMID: 17331979
    10. ISD11 is important in the biogenesis of Fe-S clusters in mammalian cells. PMID: 19454487

    顯示更多

    收起更多

  • 相關疾病:
    Combined oxidative phosphorylation deficiency 19 (COXPD19)
  • 亞細胞定位:
    Mitochondrion. Nucleus.
  • 蛋白家族:
    Complex I LYR family
  • 組織特異性:
    Reduced mRNA levels in Friedreich ataxia patients.
  • 數據庫鏈接:

    HGNC: 21365

    OMIM: 613311

    KEGG: hsa:57128

    STRING: 9606.ENSP00000443900

    UniGene: Hs.387755



主站蜘蛛池模板: 日日噜噜夜夜爽爽| 亚洲第一在线综合网站| 18无码粉嫩小泬无套在线观看| 小说区 图片区色 综合区| 日韩毛片免费无码无毒视频观看| 久激情内射婷内射蜜桃| 免费午夜无码片在线观看影院| 亚洲综合av色婷婷五月蜜臀| 天天躁日日躁狠狠躁人妻| 国产成人无码av一区二区| 又色又爽又黄的视频网站| 中文字幕乱妇无码av在线| 亚洲狠狠色丁香婷婷综合| 色五月丁香五月综合五月| 天天爽夜夜爽人人爽曰| 无码h片在线观看网站| 超碰cao已满18进入离开官网| 无码人妻久久一区二区三区app | 欧美性生 活18~19| 在线精品动漫一区二区无码| 激情无码人妻又粗又大中国人 | 中文字字幕在线中文无码| 中文字幕在线精品视频入口一区| 伦埋琪琪久久影院三级| 国产色视频一区二区三区| 冲田杏梨av一区二区三区| 久久久久国产精品人妻电影| 野花社区在线观看视频| 好爽…又高潮了免费毛片| 亚洲一区二区三区波多野结衣 | 国产69精品久久久久人妻| 国产欧美久久一区二区三区| 亚洲高请码在线精品av| 久久久久国产精品人妻aⅴ果冻| 亚洲人成网站999久久久综合| 男人用嘴添女人私密视频| 亚洲国产成人精品无码区在线软件| 国产av一二三无码影片| 亚洲男人av香蕉爽爽爽爽| 白丝乳交内射一二三区| 国产人妻精品一区二区三首|