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  4. Recombinant Human Kinesin heavy chain isoform 5C (KIF5C), partial

Recombinant Human Kinesin heavy chain isoform 5C (KIF5C), partial

  • 中文名稱：
    人KIF5C重組蛋白
  • 貨號：
    CSB-YP012343HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KIF5C重組蛋白
  • 貨號：
    CSB-EP012343HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KIF5C重組蛋白
  • 貨號：
    CSB-EP012343HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KIF5C重組蛋白
  • 貨號：
    CSB-BP012343HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KIF5C重組蛋白
  • 貨號：
    CSB-MP012343HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CDCBM2; FLJ44735; KIAA0531; KIF 5C; Kif5c; KIF5C protein; KIF5C_HUMAN; Kinesin family member 5C; Kinesin heavy chain isoform 5C; Kinesin heavy chain neuron specific 2; Kinesin heavy chain neuron specific; Kinesin heavy chain neuron-specific 2; Kinesin5C; KINN; MGC111478; NKHC 2; NKHC; NKHC-2; NKHC2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in synaptic transmission. Mediates dendritic trafficking of mRNAs. Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
  • 基因功能參考文獻：
    1. Findings point to a role for Kinesin-2 in the long-range movement of RAB5 endosomes during interphase. At the onset of mitosis, Kinesin-2 mediated transport controls timing of nuclear envelope breakdown and localization of RAB5 endosomes at spindle. PMID: 30200238
    2. KIF5C mutations are associated with a neurodevelopmental disorder characterized by infantile onset epilepsy, and subtle but recognizable types of brain malformations. PMID: 29048727
    3. Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C was much lower than the expression of dynactin subunits DCTN1 and DCTN3, in both sporadic amyotrophic lateral sclerosis and healthy cases PMID: 26954557
    4. Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function. PMID: 24812067
    5. analysis of the GRIF-1 binding domain of the kinesin, KIF5C, which substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes PMID: 16835241
    6. KIF5C, a member of the kinesin 1 heavy chain family, is a substrate for protein kinase CK2. PMID: 18682247
    7. Results identified the motor neuron protein KIF5C as a new binding partner for the protein kinase CK2alpha'. PMID: 19011756

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  • 相關疾病：
    Cortical dysplasia, complex, with other brain malformations 2 (CDCBM2)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, dendrite.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin subfamily
  • 組織特異性：
    Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.
  • 數據庫鏈接：

    HGNC: 6325

    OMIM: 604593

    KEGG: hsa:3800

    STRING: 9606.ENSP00000393379

    UniGene: Hs.435557



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