在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1), partial

Recombinant Human Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1), partial

  • 中文名稱：
    人KIR3DS1重組蛋白
  • 貨號：
    CSB-YP614817HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KIR3DS1重組蛋白
  • 貨號：
    CSB-EP614817HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KIR3DS1重組蛋白
  • 貨號：
    CSB-EP614817HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KIR3DS1重組蛋白
  • 貨號：
    CSB-BP614817HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KIR3DS1重組蛋白
  • 貨號：
    CSB-MP614817HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KIR3DS1
  • Uniprot No.：
  • 別名：
    KIR3DS1; NKAT10Killer cell immunoglobulin-like receptor 3DS1; MHC class I NK cell receptor; Natural killer-associated transcript 10; NKAT-10
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production.
  • 基因功能參考文獻：
    1. interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. PMID: 30031767
    2. The combination of KIR3DS1 with homozygosity for HLA-Bw4 alleles (the putative ligand for KIR3DS1) was significantly less frequent in the HIV-1 infected group than in the control group PMID: 29664957
    3. Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4 (Iso80) , and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups. PMID: 29032460
    4. KIR3DS1*01301, 3DL1*00401, and 3DL1*00402 showed susceptibility and elevated mRNA expression and is associated with antibody mediated acute rejection and chronic rejection. PMID: 28942035
    5. Study assessed which of the TB01 encoded KIR gene products contributed to Natural Killer cell responsiveness; of the TB01 KIR gene products examined, only KIR3DS1 conferred responsiveness to HLA-null stimulation, demonstrating its ligation can activate ex vivo Natural Killer cells. PMID: 28938026
    6. genetic polymorphism is not related to acute myeloid leukemia in Chinese population PMID: 25636577
    7. The data from this study contribute novel insight into how KIR3DS1-specific polymorphisms in the extracellular region impact KIR3DL1 surface expression, ligand binding, and inhibitory function. PMID: 26109640
    8. Data suggest that low level of activating KIR3DS1 and its combination with HLA-B Bw4Ile80 ligand might have an influence on the susceptibility to tuberculosis (TB) in Lur population of Iran. PMID: 22426166
    9. KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of ankylosing spondylitis in the Chinese population. PMID: 22744805
    10. Results show that the KIR3DS1 genotype has a positive effect on HCV viral clearance during the first weeks of Peg-IFN/RBV treatment in HCV/HCV co-infected patients bearing genotype 1, and higher RVR and SVR rates. PMID: 23613999
    11. results suggest that the sole presence of KIR3DS1 could have a protective role in HIV-1 infection in highly exposed and persistently seronegative individuals PMID: 23789883
    12. There is evidence of the association of activating KIR genotypes with an increased risk for autoimmune disease PMID: 21779711
    13. Our results that KIR2DL5 and KIR3DS1 may have a predisposing role in multiple sclerosis PMID: 21665278
    14. These data provide the first evidence for the direct binding of KIR3DS1(+) cells to HLA-Bw4 and highlight the key role for position 138 in determining ligand specificity of KIR3DS1 PMID: 21804024
    15. The most significant difference in PFS observed in multiple myeloma patients after autologous stem cell transplantation was with those with GR KIR3DS1(+) in whom HLA-Bw4, the ligand for the corresponding inhibitory receptor KIR3DL1, was missing PMID: 20562327
    16. The increased frequency of the KIR3DS1*013 allele in patients with amnkylosing spondylitis is clearly independent of the presence of the HLA-Bw4I80 epitope. PMID: 20131260
    17. Compared with KIR3DS1(-) donors, donor KIR3DS1 was associated with lower-grade II-IV acute graft-versus-host disease. PMID: 20124216
    18. Carriage of activating 3ds1 was increased in patients with herpes virus RDs. PMID: 17592337
    19. Sequencing analysis identified a variant with a complex deletion/substitution mutation in exon 4 (which encodes the D1 extracellular domain), resulting in a premature stop codon and might affect its expression and activating capacity PMID: 17687550
    20. Variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication. PMID: 18025129
    21. We observed that possessing KIR3DS1 was associated with higher NK cell effector functions in early HIV-1 disease, despite the absence of HLA Bw4Ile80, a putative ligand of KIR3DS1. PMID: 18305035
    22. KIR3DS1 expression on NK cells can be induced after exposure to stimulator cells PMID: 19454667

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 組織特異性：
    Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line.
  • 數據庫鏈接：

    HGNC: 6340

    OMIM: 604946

    KEGG: hsa:3813

    STRING: 9606.ENSP00000375608

    UniGene: Hs.645228



主站蜘蛛池模板： 亚洲国产成人精品无码区二本| 中字幕人妻一区二区三区| 天堂а√中文最新版地址在线| 国产在线观看免费观看不卡| 麻豆成人久久精品综合网址| 无码人妻av免费一区二区三区| 精品一区二区不卡无码av| 国产精品99久久免费| 人妻无码手机在线中文| 在线精品视频一区二区三区| 日本少妇裸体做爰高潮片| 狠狠色成人一区二区三区| 精品精品国产理论在线观看| 欧美日韩亚洲精品瑜伽裤 | 国内极度色诱视频网站| 国产露脸无套对白在线播放| 中文字幕乱码无码人妻系列蜜桃| 日韩加勒比一本无码精品| 无码专区无码专区视频网址| av免费不卡国产观看| 亚洲中文字幕婷婷在线| 国产美女视频国产视视频| 久久精品国产99久久6| 人人做人人爽人人爱| 久久亚洲中文字幕伊人久久大| 精品国产午夜福利精品推荐| 亚洲性啪啪无码av天堂| 亚洲乱亚洲乱妇24p| 中文国产成人精品久久久| 777亚洲精品乱码久久久久久| 欧美3p两根一起进高清视频| 欧美老熟妇牲交| 色综合天天综合网中文| 亚洲sm另类一区二区三区| 综合久久给合久久狠狠狠97色 | 欧美96在线 | 欧| 粉嫩小泬视频无码视频软件| 精品久久久久久久无码| 国产精品你懂的在线播放| 野花在线无码视频在线播放| 久久97精品久久久久久久不卡|