在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Kelch-like protein 24 (KLHL24)

  • 中文名稱:
    人KLHL24重組蛋白
  • 貨號:
    CSB-YP750981HU
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人KLHL24重組蛋白
  • 貨號:
    CSB-EP750981HU
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人KLHL24重組蛋白
  • 貨號:
    CSB-EP750981HU-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人KLHL24重組蛋白
  • 貨號:
    CSB-BP750981HU
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人KLHL24重組蛋白
  • 貨號:
    CSB-MP750981HU
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    KLHL24
  • Uniprot No.:
  • 別名:
    KLHL24; DRE1; Kelch-like protein 24; Kainate receptor-interacting protein for GluR6; KRIP6; Protein DRE1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-600
  • 氨基酸序列
    MVLILGRRLN REDLGVRDSP ATKRKVFEMD PKSLTGHEFF DFSSGSSHAE NILQIFNEFR DSRLFTDVII CVEGKEFPCH RAVLSACSSY FRAMFCNDHR ESREMLVEIN GILAEAMECF LQYVYTGKVK ITTENVQYLF ETSSLFQISV LRDACAKFLE EQLDPCNCLG IQRFADTHSL KTLFTKCKNF ALQTFEDVSQ HEEFLELDKD ELIDYICSDE LVIGKEEMVF EAVMRWVYRA VDLRRPLLHE LLTHVRLPLL HPNYFVQTVE VDQLIQNSPE CYQLLHEARR YHILGNEMMS PRTRPRRSTG YSEVIVVVGG CERVGGFNLP YTECYDPVTG EWKSLAKLPE FTKSEYAVCA LRNDILVSGG RINSRDVWIY NSQLNIWIRV ASLNKGRWRH KMAVLLGKVY VVGGYDGQNR LSSVECYDSF SNRWTEVAPL KEAVSSPAVT SCVGKLFVIG GGPDDNTCSD KVQSYDPETN SWLLRAAIPI AKRCITAVSL NNLIYVAGGL TKAIYCYDPV EDYWMHVQNT FSRQENCGMS VCNGKIYILG GRRENGEATD TILCYDPATS IITGVAAMPR PVSYHGCVTI HRYNEKCFKL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
  • 基因功能參考文獻:
    1. KLHL24 mutation is associated in the pathogenesis of skin abnormalities and epidermolysis bullosa simplex. PMID: 28532758
    2. KLHL24 Mutation is associated with epidermolysis bullosa. PMID: 27798626
    3. findings identify KLHL24 mutations as a cause of skin fragility and identify a role for KLHL24 in maintaining the balance between intermediate filament stability and degradation required for skin integrity PMID: 27889062
    4. Data show that a miRNA, hsv1-mir-H27, encoded within the genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the cellular transcriptional repressor Kelch-like 24 (KLHL24). PMID: 23512275
    5. KRIP6 regulates kainate receptors by inhibiting PICK1 modulation via competition or a mutual blocking effect PMID: 18692513

    顯示更多

    收起更多

  • 相關疾病:
    Epidermolysis bullosa simplex, generalized, with scarring and hair loss (EBSSH)
  • 亞細胞定位:
    Perikaryon. Cell projection, axon. Cytoplasm. Cell junction, desmosome. Cell junction, adherens junction.
  • 組織特異性:
    Expressed in the skin. Found in keratinocytes, dermal fibroblasts, and melanocytes. Basal-layer keratinocytes have lower KLHL24 expression than suprabasal keratinocytes.
  • 數據庫鏈接:

    HGNC: 25947

    OMIM: 611295

    KEGG: hsa:54800

    STRING: 9606.ENSP00000242810

    UniGene: Hs.407709



主站蜘蛛池模板: 尹人香蕉久久99天天拍久女久| 亚洲国产欧美一区点击进入| 激情偷乱人成视频在线观看| 欧美一道本一区二区三区| 亚洲另类欧美在线电影| 狠狠做五月深爱婷婷| 亚洲成av人片在线观看天堂无码| 少妇av一区二区三区无码| 色情无码一区二区三区| 最新国产精品好看的精品| 中老年熟妇激情啪啪大屁股| 色久悠悠婷婷综合在线亚洲| 四虎国产精品免费久久久| 亚洲综合色自拍一区| 98视频精品全部国产| 亚洲中文字幕无码卡通动漫野外| 又嫩又硬又黄又爽的视频| 亚洲成a人片在线观看www| 中文字幕在线观看| 又湿又紧又大又爽又a视频| 一中文字幕日产乱码va| 天天躁夜夜躁av天天爽| 久久久久国产精品人妻| 国产成人午夜福利在线播放| 亚洲精品综合欧美一区二区三区| 国产欧美成人一区二区a片| 成人精品视频一区二区| 国产69久久精品成人看| 无码国产玉足脚交极品网站| 肉体裸交137日本大胆摄影 | 成年女人黄小视频| 免费观看羞羞视频网站| 亚洲国产成人av人片久久| 日本一区二区三区不卡免费| 亚洲午夜福利院在线观看| 五月丁香啪啪| 日日噜噜夜夜狠狠久久蜜桃| 午夜免费啪视频在线观看区| 精品蜜臀久久久久99网站| 久久国产成人精品国产成人亚洲| 亚洲乱码无人区卡1卡2卡3|