在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Junction-mediating and -regulatory protein (JMY), partial

Recombinant Human Junction-mediating and -regulatory protein (JMY), partial

  • 中文名稱：
    人JMY重組蛋白
  • 貨號：
    CSB-YP850838HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人JMY重組蛋白
  • 貨號：
    CSB-EP850838HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人JMY重組蛋白
  • 貨號：
    CSB-EP850838HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人JMY重組蛋白
  • 貨號：
    CSB-BP850838HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人JMY重組蛋白
  • 貨號：
    CSB-MP850838HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    JMY
  • Uniprot No.：
  • 別名：
    FLJ37870; Jmy; JMY protein; JMY_HUMAN; junction mediating and regulatory protein ; Junction mediating and regulatory protein p53 cofactor; Junction-mediating and -regulatory protein; MGC163496 ; OTTHUMP00000161976; WAS protein homology region 2 domain containing 1-like 3; WHDC1L3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
  • 基因功能參考文獻(xiàn)：
    1. In autophagosomes, the integrity of the WH2 domains allows JMY to promote actin nucleation, which is required for efficient autophagosome formation. PMID: 26223951
    2. JMY was expressed in normal tissues and heterogeneously in different tumor types, with close correlation between cytoplasmic and nuclear expression. PMID: 25280461
    3. JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients. PMID: 24069348
    4. JMY is related to the severity of AS in Chinese Han patients. PMID: 23758122
    5. actin assembly regulates nuclear import of JMY in response to DNA damage. PMID: 22262458
    6. JMY is expressed at high levels in brain tissue, and in various cell lines JMY is predominantly cytoplasmic, with a minor fraction in the nucleus. PMID: 21965285
    7. results establish the interplay between JMY and HIF-1alpha as a new mechanism that controls cell motility under hypoxic stress PMID: 21625218
    8. Data demonstrate a pathway that links the cytoskeleton with the p53 response, and further suggest that the ability of JMY to regulate actin and cadherin is instrumental in coordinating cell motility with the p53 response. PMID: 19897726
    9. JMY represents a new class of multifunctional actin assembly factor whose activity is regulated, at least in part, by sequestration in the nucleus. PMID: 19287377

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    JMY family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28916

    OMIM: 604279

    KEGG: hsa:133746

    STRING: 9606.ENSP00000379441

    UniGene: Hs.482605



主站蜘蛛池模板： 99riav国产精品视频| 人人妻人人澡人人爽精品欧美 | 日韩免费无码人妻波多野| 久久好在线视频| 国产成人精品久久| 国产成人vr精品a视频| 日韩在线视频线观看一区| 亚洲国产品综合人成综合网站| 日本精品高清一区二区| 婷婷国产成人精品视频| 天堂а√中文最新版在线| 无码人妻在线一区二区三区免费| 国产精品无码无卡在线播放| 国产边打电话边被躁视频| 一线二线三线天堂| 欧美成人精精品一区二区| 无码专区丰满人妻斩六十路| 成人无码视频| 天干天干天啪啪夜爽爽99| 亚洲国产欧美不卡在线观看| 三级做爰高清视频| 韩国乱码伦视频免费| 久久久噜噜噜久噜久久| 午夜福利午夜福利1000| 怡红院av亚洲一区二区三区h| 亚洲已满18点击进入在线看片| 337p人体 欧洲人体 亚洲| 国产av无码精品色午夜| 亚洲国产精品尤物yw在线观看| 人妻熟女一区二区aⅴ林晓雪| 人人玩人人添人人澡| 人妻系列无码专区免费视频| 亚洲国产av无码精品| 国产精品亚洲成在人线| 18禁超污无遮挡无码网址| 华人少妇被黑人粗大的猛烈进 | 成人性做爰aaa片免费| www国产精品内射老熟女| 国内精品久久人妻无码网站| 国产亚洲精品久久yy50| av午夜久久蜜桃传媒软件|