在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. JMY Antibody

JMY Antibody

  • 中文名稱：
    JMY兔多克隆抗體
  • 貨號：
    CSB-PA003083
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using JMY Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    JMY
  • 別名：
    FLJ37870 antibody; Jmy antibody; JMY protein antibody; JMY_HUMAN antibody; junction mediating and regulatory protein antibody; Junction mediating and regulatory protein p53 cofactor antibody; Junction-mediating and -regulatory protein antibody; MGC163496 antibody; OTTHUMP00000161976 antibody; WAS protein homology region 2 domain containing 1-like 3 antibody; WHDC1L3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human JMY.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
  • 基因功能參考文獻：
    1. In autophagosomes, the integrity of the WH2 domains allows JMY to promote actin nucleation, which is required for efficient autophagosome formation. PMID: 26223951
    2. JMY was expressed in normal tissues and heterogeneously in different tumor types, with close correlation between cytoplasmic and nuclear expression. PMID: 25280461
    3. JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients. PMID: 24069348
    4. JMY is related to the severity of AS in Chinese Han patients. PMID: 23758122
    5. actin assembly regulates nuclear import of JMY in response to DNA damage. PMID: 22262458
    6. JMY is expressed at high levels in brain tissue, and in various cell lines JMY is predominantly cytoplasmic, with a minor fraction in the nucleus. PMID: 21965285
    7. results establish the interplay between JMY and HIF-1alpha as a new mechanism that controls cell motility under hypoxic stress PMID: 21625218
    8. Data demonstrate a pathway that links the cytoskeleton with the p53 response, and further suggest that the ability of JMY to regulate actin and cadherin is instrumental in coordinating cell motility with the p53 response. PMID: 19897726
    9. JMY represents a new class of multifunctional actin assembly factor whose activity is regulated, at least in part, by sequestration in the nucleus. PMID: 19287377

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    JMY family
  • 數據庫鏈接：

    HGNC: 28916

    OMIM: 604279

    KEGG: hsa:133746

    STRING: 9606.ENSP00000379441

    UniGene: Hs.482605



主站蜘蛛池模板： 久久婷婷成人综合色综合| 亚洲香蕉网久久综合影视| 美女黄频视频大全免费的国内| 国产在线清纯极品美女援交| 2019最新中文字幕在线观看| 鲁大师在线视频播放免费观看| 美女裸体十八禁免费网站| 四虎国产精亚洲一区久久特色| 77777亚洲午夜久久多喷| 骚动漫十八禁在线观看| 国产精品国产精品国产专区不卡| 乌克兰少妇性做爰| 国产欲女高潮正在播放| 欧美成人看片一区二三区图文| 嫖妓大龄熟妇正在播放| 无码人妻h动漫| 真人作爱免费视频| 女邻居的大乳中文字幕| 午夜精品久久久久9999| 久久精品亚洲国产av老鸭网| 少妇人妻久久无码专区| 久青青视频在线观看久| 成 人片 黄 色 大 片| 粗大挺进尤物人妻中文字幕 | 国产亚洲精品久久久久久入口| 永久黄网站色视频免费看| 成人区人妻精品一区二区不卡网站 | 开心色怡人综合网站| 宅女午夜福利免费视频| 国产精品成人久久久久久久| 色猫咪免费人成网站在线观看| 日本免费一区二区三区四区五区| 精品人妻av区乱码| 高清破外女出血av毛片| 亚洲国产老鸭窝一区二区三区| 精品国产一区二区三区无码| 中文字幕无码中文字幕有码 | 中文无码成人免费视频在线观看| 亚洲成在线aⅴ免费视频| 男女啪啪永久免费网站| 四虎影视成人永久免费观看视频|