在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Isoaspartyl peptidase/L-asparaginase (ASRGL1), partial

Recombinant Human Isoaspartyl peptidase/L-asparaginase (ASRGL1), partial

  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-YP755484HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-EP755484HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-EP755484HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-BP755484HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-MP755484HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ASRGL1; ALP; CRASHIsoaspartyl peptidase/L-asparaginase; EC 3.4.19.5; EC 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    partial
  • 表達區域：
    168-308
  • 氨基酸序列
    TVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILK VNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAA AKDGKLHFGIDPDDTTITDLP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
  • 基因功能參考文獻：
    1. ASRGL1 was closely associated with growth and apoptosis in cervical cancer. Therefore, ASRGL1 may be a novel, potentially effective anticervical cancer therapy. PMID: 29767260
    2. A panel including p53 and ASRGL1 immunohistochemistry was identified as the most accurate predictor of relapse-free and disease-specific survival. Within this panel, patients were allocated into high- (5.9%), intermediate- (29.5%) and low- (64.6%) risk groups where high-risk patients had a 30-fold risk (P<0.001) of dying of EEC compared to the low-risk group. PMID: 29486992
    3. In a prospective setting ASRGL1 validates as a strong prognostic biomarker in endometrial carcinoma. Loss of ASRGL1 is associated with aggressive disease and poor survival. PMID: 29096882
    4. Our studies suggest that the p.G178R mutation in ASRGL1 leads to photoreceptor degeneration resulting in progressive vision loss. PMID: 27106100
    5. Multiple negatively charged small molecules interact within the active site of ASRGL1 to act as a base in promoting cleavage. PMID: 26780688
    6. Reduced expression of ASRGL1, defined as <75% positively stained tumor cells, was significantly associated with poor prognosis and reduced disease-specific survival in endometrioid endometrial adenocarcinoma (EEA). PMID: 25858696
    7. Determined is the structure of the first mammalian plant-type asparaginase in both a precursor and fully activated form. PMID: 22891768
    8. Human ALP cDNA was subsequently cloned. It showed 77% identity to the rat ALP sequence and the gene, ASRGL1 (asparaginase-like 1), mapped to chromosome locus 11q12.3. PMID: 11984834
    9. Overexpression of CRASH is associated with metastatic breast cancer. PMID: 19414332
    10. ASRGL1 exhibits beta-aspartyl peptidase activity consistent with plant-type asparaginases. ASRGL1 is shown to be an Ntn hydrolase for which Thr168 serves as the essential N-terminal nucleophile for intramolecular processing and catalysis. PMID: 19839645

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Note=Midpiece of sperm tail.
  • 蛋白家族：
    Ntn-hydrolase family
  • 組織特異性：
    Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.
  • 數據庫鏈接：

    HGNC: 16448

    OMIM: 609212

    KEGG: hsa:80150

    STRING: 9606.ENSP00000301776

    UniGene: Hs.535326



主站蜘蛛池模板： 日本乱偷互换人妻中文字幕| 国产av一区二区三区日韩| 国产亚洲精品久久久久久久久动漫| 成 人 在 线 免费观看| 国产精品乱子伦xxxx裸| 成人无码一区二区三区网站| 国产亚洲中文字幕在线制服| 国产精品亚洲专区无码唯爱网| 揄拍成人国产精品视频| 人妻系列无码专区久久五月天| 亚洲国产成人超a在线播放| 激情国产一区二区三区四区| 亚洲国产av无码精品| av无码一区二区大桥久未| 亚洲 欧美 自拍 美腿 卡通| 夜夜爱夜鲁夜鲁很鲁| 狠狠cao日日穞夜夜穞av| 海角社区在线视频播放观看| 被技师按摩到高潮的少妇| 热久久视久久精品18| 少妇特黄a一区二区三区| 欧美日韩精品无码一本二本三本色 | 亚洲成av人片在线观看橙子| 夜夜躁天天躁很很躁| 风韵丰满熟妇啪啪区老老熟妇| 妺妺跟我一起洗澡没忍住| 男女啪啦猛视频免费| 久久精品aⅴ无码中文字字幕蜜桃 午夜成人鲁丝片午夜精品 | av香港经典三级级 在线| 精品国产免费一区二区三区 | 开心色怡人综合网站| 中文字幕人妻熟女人妻| 高潮添下面视频免费看| 偷窥国产亚洲免费视频| 被拉到野外强要好爽黑人| 美女张开腿黄网站免费| 欧美激欧美啪啪片免费看| 亚洲精品一区二区中文字幕| 日日碰狠狠添天天爽无码 | 无码少妇一区二区浪潮免费| 嘿咻嘿咻男女免费专区|