在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Isoaspartyl peptidase/L-asparaginase (ASRGL1), partial

Recombinant Human Isoaspartyl peptidase/L-asparaginase (ASRGL1), partial

  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-YP755484HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-EP755484HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-EP755484HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-BP755484HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Isoaspartyl peptidase/L-asparaginase(ASRGL1),partial
  • 貨號：
    CSB-MP755484HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ASRGL1; ALP; CRASHIsoaspartyl peptidase/L-asparaginase; EC 3.4.19.5; EC 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    partial
  • 表達區域：
    168-308
  • 氨基酸序列
    TVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILK VNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAA AKDGKLHFGIDPDDTTITDLP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
  • 基因功能參考文獻：
    1. ASRGL1 was closely associated with growth and apoptosis in cervical cancer. Therefore, ASRGL1 may be a novel, potentially effective anticervical cancer therapy. PMID: 29767260
    2. A panel including p53 and ASRGL1 immunohistochemistry was identified as the most accurate predictor of relapse-free and disease-specific survival. Within this panel, patients were allocated into high- (5.9%), intermediate- (29.5%) and low- (64.6%) risk groups where high-risk patients had a 30-fold risk (P<0.001) of dying of EEC compared to the low-risk group. PMID: 29486992
    3. In a prospective setting ASRGL1 validates as a strong prognostic biomarker in endometrial carcinoma. Loss of ASRGL1 is associated with aggressive disease and poor survival. PMID: 29096882
    4. Our studies suggest that the p.G178R mutation in ASRGL1 leads to photoreceptor degeneration resulting in progressive vision loss. PMID: 27106100
    5. Multiple negatively charged small molecules interact within the active site of ASRGL1 to act as a base in promoting cleavage. PMID: 26780688
    6. Reduced expression of ASRGL1, defined as <75% positively stained tumor cells, was significantly associated with poor prognosis and reduced disease-specific survival in endometrioid endometrial adenocarcinoma (EEA). PMID: 25858696
    7. Determined is the structure of the first mammalian plant-type asparaginase in both a precursor and fully activated form. PMID: 22891768
    8. Human ALP cDNA was subsequently cloned. It showed 77% identity to the rat ALP sequence and the gene, ASRGL1 (asparaginase-like 1), mapped to chromosome locus 11q12.3. PMID: 11984834
    9. Overexpression of CRASH is associated with metastatic breast cancer. PMID: 19414332
    10. ASRGL1 exhibits beta-aspartyl peptidase activity consistent with plant-type asparaginases. ASRGL1 is shown to be an Ntn hydrolase for which Thr168 serves as the essential N-terminal nucleophile for intramolecular processing and catalysis. PMID: 19839645

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Note=Midpiece of sperm tail.
  • 蛋白家族：
    Ntn-hydrolase family
  • 組織特異性：
    Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.
  • 數據庫鏈接：

    HGNC: 16448

    OMIM: 609212

    KEGG: hsa:80150

    STRING: 9606.ENSP00000301776

    UniGene: Hs.535326



主站蜘蛛池模板： 国产做爰xxxⅹ高潮视频12p| 男女后式激烈动态图片| 欧美疯狂做受xxxxx高潮| 久久综合一色综合久久小蛇 | аⅴ天堂中文在线网官网| 国产在线无码制服丝袜无码| 免费国产黄网站在线观看可以下载 | 人妻aⅴ中文字幕| 日韩高清成片免费视频| 亚洲欧洲日产国码无码| 性开放的女人aaa片| 亚洲人成小说网站色在线| 日日婷婷夜日日天干| 在线观看无码av网址| 爽爽影院免费观看| 5x性社区免费视频播| 日本高清中文字幕免费一区二区 | 国产精品久久久久影院老司| 天堂网在线最新版www资源网| 国产精品黄页免费高清在线观看| 日本乱人伦aⅴ精品| 夜夜春夜夜爽| 香蕉久久一区二区三区啪啪| 无码国产一区二区三区四区| 无码帝国www无码专区色综合 | 特级做a爰片毛片免费69| 内射人妻无套中出无码| 一本一道色欲综合网| 精品久久久久久久中文字幕| 国产妇女馒头高清泬20p多毛| 亚洲aⅴ在线无码天堂777| 四虎永久地址www成人久久| а√在线中文网新版地址在线 | 亚洲小说图区综合在线| 久久久久人妻精品区一三寸| 亚洲大尺度无码专区尤物| 久久亚洲国产成人影院| 久久亚洲精品无码gv| 精品久久久久久中文字幕大豆网| 少妇久久久久久久久久| 亚洲综合色婷婷六月丁香宅男大增 |