在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Intraflagellar transport protein 57 homolog (IFT57)

Recombinant Human Intraflagellar transport protein 57 homolog (IFT57)

  • 中文名稱：
    人IFT57重組蛋白
  • 貨號：
    CSB-YP865156HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人IFT57重組蛋白
  • 貨號：
    CSB-EP865156HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人IFT57重組蛋白
  • 貨號：
    CSB-EP865156HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人IFT57重組蛋白
  • 貨號：
    CSB-BP865156HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人IFT57重組蛋白
  • 貨號：
    CSB-MP865156HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    IFT57
  • Uniprot No.：
  • 別名：
    CDNA FLJ10147 fis clone HEMBA1003369; Dermal papilla derived protein 8; Dermal papilla-derived protein 8; DERP 8; DERP8; Esrrbl 1; Esrrbl1; ESRRBL1 protein; Estrogen related receptor beta like 1; Estrogen related receptor beta like protein 1; Estrogen-related receptor beta-like protein 1; FLJ10147; Hip1 Interacting protein; HIP1 interacting protein HIPPI; Hip1 protein interactor; HIP1-interacting protein; HIPPI; Huntingtin interacting protein 1 interacting protein; Huntingtin interacting protein 1 protein interactor; IFT 57; ift57; IFT57_HUMAN; Intraflagellar transport 57 homolog (Chlamydomonas); Intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2; Vestrogen related receptor beta like 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-429
  • 氨基酸序列
    MTAALAVVTT SGLEDGVPRS RGEGTGEVVL ERGPGAAYHM FVVMEDLVEK LKLLRYEEEF LRKSNLKAPS RHYFALPTNP GEQFYMFCTL AAWLINKAGR PFEQPQEYDD PNATISNILS ELRSFGRTAD FPPSKLKSGY GEHVCYVLDC FAEEALKYIG FTWKRPIYPV EELEEESVAE DDAELTLNKV DEEFVEEETD NEENFIDLNV LKAQTYHLDM NETAKQEDIL ESTTDAAEWS LEVERVLPQL KVTIRTDNKD WRIHVDQMHQ HRSGIESALK ETKGFLDKLH NEITRTLEKI SSREKYINNQ LENLVQEYRA AQAQLSEAKE RYQQGNGGVT ERTRLLSEVM EELEKVKQEM EEKGSSMTDG APLVKIKQSL TKLKQETVEM DIRIGIVEHT LLQSKLKEKS NMTRNMHATV IPEPATGFY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
  • 基因功能參考文獻：
    1. sequencing of IFT57 in 13 OFDS subjects and 12 subjects with Ellis-Van Creveld syndrome was negative. This report identifies the implication of IFT57 in human pathology and highlights the first description of a ciliary transport defect in OFDS, extending the genetic heterogeneity of this subgroup of ciliopathies. PMID: 27060890
    2. HIPPI-P53 interaction was necessary for HIPPI mediated up-regulation of Caspase1 gene. PMID: 21943362
    3. novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease. PMID: 21832040
    4. Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway. PMID: 11788820
    5. critical for the death-promoting effects of mutant huntingtin protein in cultured cells PMID: 11807533
    6. Hippi interacts with the viral death protein Apoptin. PMID: 12745083
    7. Hippi expression induced apoptosis by releasing AIF and cytochrome c from mitochondria, activation of caspase-1 and caspase-3, and altering the expression of apoptotic genes and genes involved in mitochondrial complex I and II. PMID: 16364650
    8. Crystals of the pDED of HIPPI were grown in space group P4(1), with unit-cell parameters a = b = 77.42, c = 33.31 A and a calculated Matthews coefficient of 1.88 A3 Da(-1) (33% solvent content) with two molecules per asymmetric unit. PMID: 17142908
    9. In summary, we showed that HIPPI could interact with the putative promoter sequence of caspase-1 and increased the expression of the downstream gene suggesting that HIPPI could act as transcription regulator. PMID: 17173859
    10. Over-expression of BLOC1S2 in presence or absence of HIPPI does not induce apoptosis. However, BLOC1S2 & HIPPI sensitize NCH89 glioblastoma cells to pro-apoptotic actions of staurosporine & death ligand TRAIL. PMID: 18188704

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    IFT57 family
  • 組織特異性：
    Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
  • 數據庫鏈接：

    HGNC: 17367

    OMIM: 606621

    KEGG: hsa:55081

    STRING: 9606.ENSP00000264538

    UniGene: Hs.412196



主站蜘蛛池模板： 亚洲精品无码中文久久字幕| 桃花综合久久久久久久久久网| 欧美人与动人物牲交免费观看| av无码国产在线看免费网站 | 人妻熟妇乱又伦精品视频| 情侣黄网站免费看| 亚洲一区二区三区无码久久| 天堂√最新版中文在线天堂 | 日本亲子乱子伦xxxx50路| 777午夜精品免费观看| 国产精品老热丝在线观看| 国产精品高潮呻吟av久久无吗| 亚洲国产精品成人综合色| 久久99精品国产99久久6不卡| 精品无码一区二区三区在线| 亚洲国产一卡2卡3卡4卡5公司| 风韵人妻丰满熟妇老熟女| 国产a线视频播放| 免费很黄无遮挡的视频| 无码人妻精品中文字幕免费东京热 | 国产成人综合亚洲精品| 精品国产三级a在线观看网站| 免费毛儿一区二区十八岁| 国产精品久久久久久久久久久久| 国产日产欧产精品精品推荐免费| 亚洲精品无码不卡av| 国产又粗又猛又黄又爽无遮挡| 蜜桃av色偷偷av老熟女| 久久婷婷大香萑太香蕉av人| 亲子乱子伦xxxx视频| 天天躁日日躁狠狠躁欧美老妇 | 亚洲精品美女久久7777777| 在线亚洲欧美日韩精品专区| av无码午夜福利一区二区三区| 国产精品无套呻吟在线| 强开小婷嫩苞又嫩又紧视频韩国| 成人网站色52色在线观看| 久久99国产精品久久99| 日本午夜免费福利视频| 3d动漫精品啪啪一区二区中| 亚洲а∨天堂男人色无码|