在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IFT57 Antibody

IFT57 Antibody

  • 中文名稱：
    IFT57兔多克隆抗體
  • 貨號：
    CSB-PA011076GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    IFT57
  • 別名：
    CDNA FLJ10147 fis clone HEMBA1003369 antibody; Dermal papilla derived protein 8 antibody; Dermal papilla-derived protein 8 antibody; DERP 8 antibody; DERP8 antibody; Esrrbl 1 antibody; Esrrbl1 antibody; ESRRBL1 protein antibody; Estrogen related receptor beta like 1 antibody; Estrogen related receptor beta like protein 1 antibody; Estrogen-related receptor beta-like protein 1 antibody; FLJ10147 antibody; Hip1 Interacting protein antibody; HIP1 interacting protein HIPPI antibody; Hip1 protein interactor antibody; HIP1-interacting protein antibody; HIPPI antibody; Huntingtin interacting protein 1 interacting protein antibody; Huntingtin interacting protein 1 protein interactor antibody; IFT 57 antibody; ift57 antibody; IFT57_HUMAN antibody; Intraflagellar transport 57 homolog (Chlamydomonas) antibody; Intraflagellar transport 57 homolog antibody; Intraflagellar transport protein 57 homolog antibody; MHS4R2 antibody; Vestrogen related receptor beta like 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human IFT57
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
  • 基因功能參考文獻：
    1. sequencing of IFT57 in 13 OFDS subjects and 12 subjects with Ellis-Van Creveld syndrome was negative. This report identifies the implication of IFT57 in human pathology and highlights the first description of a ciliary transport defect in OFDS, extending the genetic heterogeneity of this subgroup of ciliopathies. PMID: 27060890
    2. HIPPI-P53 interaction was necessary for HIPPI mediated up-regulation of Caspase1 gene. PMID: 21943362
    3. novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease. PMID: 21832040
    4. Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway. PMID: 11788820
    5. critical for the death-promoting effects of mutant huntingtin protein in cultured cells PMID: 11807533
    6. Hippi interacts with the viral death protein Apoptin. PMID: 12745083
    7. Hippi expression induced apoptosis by releasing AIF and cytochrome c from mitochondria, activation of caspase-1 and caspase-3, and altering the expression of apoptotic genes and genes involved in mitochondrial complex I and II. PMID: 16364650
    8. Crystals of the pDED of HIPPI were grown in space group P4(1), with unit-cell parameters a = b = 77.42, c = 33.31 A and a calculated Matthews coefficient of 1.88 A3 Da(-1) (33% solvent content) with two molecules per asymmetric unit. PMID: 17142908
    9. In summary, we showed that HIPPI could interact with the putative promoter sequence of caspase-1 and increased the expression of the downstream gene suggesting that HIPPI could act as transcription regulator. PMID: 17173859
    10. Over-expression of BLOC1S2 in presence or absence of HIPPI does not induce apoptosis. However, BLOC1S2 & HIPPI sensitize NCH89 glioblastoma cells to pro-apoptotic actions of staurosporine & death ligand TRAIL. PMID: 18188704

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    IFT57 family
  • 組織特異性：
    Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
  • 數據庫鏈接：

    HGNC: 17367

    OMIM: 606621

    KEGG: hsa:55081

    STRING: 9606.ENSP00000264538

    UniGene: Hs.412196



主站蜘蛛池模板： 中本亚洲欧美国产日韩| 免费看男女做羞羞的事网站| 国产黑色丝袜视频在线观看网红| 97久久人人超碰国产精品| 伊人色合天天久久综合网| 两口子交换真实刺激高潮| 成年丰满熟妇午夜免费视频| 亚洲国精产品一二二线| 成人做爰视频www网站小优视频| 女人被狂爆到高潮免费视频| 亚洲日本在线在线看片| 色综合亚洲一区二区小说性色aⅴ| 蜜桃av噜噜一区二区三区| 亚洲色精品aⅴ一区区三区| 国产高清av首播原创麻豆| 精品亚洲国产成av人片传媒| 国产精品免费观看调教网| 国产尤物精品自在拍视频首页| 五月丁香六月综合缴清无码| 亚洲精品tv久久久久久久久久| 又湿又紧又大又爽又a视频| 国产一卡2卡3卡4卡精品| 国产一区二区三区精品视频 | 日韩av无码久久一区二区| 国产成人精品视频网站| av无码av在线a∨天堂毛片| av午夜福利一片免费看久久| 亚洲欧美日韩国产成人精品影院| 日本在线高清不卡免费播放| 国产sm鞭打折磨调教视频 | 精品国产自在现线看久久| 一个人看的www视频免费观看 | 久久国产色欲av38| 天堂中文在线8最新版地址| 狠狠躁天天躁中文字幕| 国产精品国产三级国产a| 欧洲熟妇色xxxxx视频| 九九99精品久久久久久综合| 全国最大成人网| 欧洲熟妇色xxxxx欧美老妇伦| 久久亚洲精品高潮综合色a片|