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Recombinant Human Immediate early response 3-interacting protein 1 (IER3IP1 HSPC039)

  • 中文名稱:
  • 貨號:
    CSB-YP2808HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2808HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2808HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2808HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2808HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    IR3IP
  • Uniprot No.:
  • 別名:
    Immediate early response 3-interacting protein 1 IER3IP1 HSPC039
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR).
  • 基因功能參考文獻:
    1. 233 T > C mutation in the IER3IP1 causes microcephaly with simplified gyral pattern, epilepsy and permanent neonatal diabetes syndrome. PMID: 28711742
    2. We expand the phenotypic spectrum of MEDS caused by IER3IP1 gene mutations and propose that WRS and MEDS are overlapping clinical syndromes, displaying significant gene-dependent clinical variability. PMID: 22991235
    3. Inhibiting the expression of IER3IP1 can inhibit erythroid differentiation and elevate the proliferation of K562 cells. PMID: 19951536
    4. IER3IP1 gene expression is regulated by Sp1, Sp3, and the TNF-a; induction of the gene in HepG2 liver cancer cell line PMID: 19885854
    5. IER3IP1 gene was mapped to chromosome 18q12 and showed a high expression in heart, skeletal muscle and kidney, a moderate expression in liver and brain and a low expression in placenta, lung and peripheral blood leukocyte. PMID: 15276200
    6. Matrine can inhibit the growth of K562 cells, and transiently increase the expression level of IER3IP1 gene in a dose-dependent manner. PMID: 18476594

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  • 相關(guān)疾病:
    Microcephaly, epilepsy, and diabetes syndrome (MEDS)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    YOS1 family
  • 組織特異性:
    Highest levels in heart, skeletal muscle, and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18550

    OMIM: 609382

    KEGG: hsa:51124

    STRING: 9606.ENSP00000465194

    UniGene: Hs.130917



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