在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Hyaluronan and proteoglycan link protein 1 (HAPLN1)

In Stock
  • 中文名稱:
    人HAPLN1重組蛋白
  • 貨號:
    CSB-EP010130HUe1
  • 規格:
    ¥2832
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    HAPLN1
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    38.6 kDa
  • 表達區域:
    16-354aa
  • 氨基酸序列
    DHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLPCKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDSDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
  • 基因功能參考文獻:
    1. HAPLN1 reflects a signaling network leading to stemness, mesenchymal commitment and hepatocellular carcinoma progression PMID: 27191501
    2. CSGalNAcT-1 and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis. PMID: 23748413
    3. HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells PMID: 22159717
    4. Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women. PMID: 20953637
    5. An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation. PMID: 20584105
    6. link protein may function as a stabilizer of the interaction between aggrecan and hyaluronan in cartilage and between versican and hyaluronan in many tissues PMID: 14724283
    7. SOX9 is a key regulator of CRTL1 PMID: 15456769
    8. cLP and versican did not bind directly to each other in solution yet formed ternary complexes with hyaluronan PMID: 15590670
    9. Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment. PMID: 19351750

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    HAPLN family
  • 組織特異性:
    Widely expressed. Weakly expressed in the brain.
  • 數據庫鏈接:

    HGNC: 2380

    OMIM: 115435

    KEGG: hsa:1404

    STRING: 9606.ENSP00000274341

    UniGene: Hs.2799



主站蜘蛛池模板: 久久久国产精华液| 日本人妻巨大乳挤奶水| 少妇内射高潮福利炮| 中文成人无码精品久久久不卡| 天天躁夜夜躁狠狠躁2021 | 久久人妻少妇嫩草av无码专区| 国产精品免费无遮挡无码永久视频| 男男女女爽爽爽免费视频| 欧美伦费免费全部午夜最新| 国产女人高潮毛片| 久久国产精品福利一区二区三区| 一本之道高清乱码久久久| 欧美老肥熟妇多毛xxxxx| 国产热re99久久6国产精品首页| 午夜精品久久久久久中宇| 中文字幕三级人妻无码视频| 国产果冻豆传媒麻婆| 久久婷婷成人综合色综合| 免费无码不卡视频在线观看| 亚洲色婷婷婷婷五月基地| 中文午夜人妻无码看片| 女人被狂c躁到高潮视频| 香蕉午夜福利院| 国产麻豆一精品av一免费软件| 在线中文字幕亚洲日韩2020| 女人高潮被爽到呻吟在线观看| 欧美亅性猛交内射| 亚洲麻豆av成本人无码网站| 中文字幕乱偷无码av先锋| 国产美女在线精品免费观看| 日韩人妻无码免费视频一二区 | 国产成人亚洲精品无码最新| 亚洲va在线∨a天堂va欧美va| 精品一区二区三区免费毛片爱 | 欧美 亚洲 国产 制服 中文 | 东京热加勒比无码少妇| 免费国产a国产片高清| 天堂在线最新版资源www| 一本久久精品一区二区| 日韩一区二区在线观看视频| 日本午夜看x费免|