在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Hyaluronan and proteoglycan link protein 1 (HAPLN1)

In Stock
  • 中文名稱:
    人HAPLN1重組蛋白
  • 貨號:
    CSB-EP010130HUe1
  • 規格:
    ¥2832
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    HAPLN1
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    38.6 kDa
  • 表達區域:
    16-354aa
  • 氨基酸序列
    DHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLPCKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDSDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
  • 基因功能參考文獻:
    1. HAPLN1 reflects a signaling network leading to stemness, mesenchymal commitment and hepatocellular carcinoma progression PMID: 27191501
    2. CSGalNAcT-1 and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis. PMID: 23748413
    3. HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells PMID: 22159717
    4. Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women. PMID: 20953637
    5. An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation. PMID: 20584105
    6. link protein may function as a stabilizer of the interaction between aggrecan and hyaluronan in cartilage and between versican and hyaluronan in many tissues PMID: 14724283
    7. SOX9 is a key regulator of CRTL1 PMID: 15456769
    8. cLP and versican did not bind directly to each other in solution yet formed ternary complexes with hyaluronan PMID: 15590670
    9. Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment. PMID: 19351750

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    HAPLN family
  • 組織特異性:
    Widely expressed. Weakly expressed in the brain.
  • 數據庫鏈接:

    HGNC: 2380

    OMIM: 115435

    KEGG: hsa:1404

    STRING: 9606.ENSP00000274341

    UniGene: Hs.2799



主站蜘蛛池模板: 久久久精品久久久久久96| 人妻聚色窝窝人体www一区| 久久精品国产成人av| 精品久久久无码中文字幕边打电话| 国产精品毛片完整版视频| 国产亚洲va在线电影| 天堂中文在线www天堂在线| 特级毛片爽www免费版| 久久综合九色综合97婷婷| 色94色欧美sute亚洲线路一 | 色妞www精品视频| 麻豆 美女 丝袜 人妻 中文| 久久久喷潮一区二区三区| 国产一卡二卡三新区2022| 国内自拍视频一区二区三区| 亚洲精品av中文字幕在线| 久久久774这里只有精品17| 久久精品第九区免费观看| 国产午夜精品一区理论片飘花| 少妇挑战黑人高潮惨叫| 久久综合久久爱久久综合伊人 | 成人永久免费网站在线观看| 日韩丝袜欧美人妻制服| 亚洲国产精品久久久久网站| 欧美日韩中文国产一区发布| 肥臀浪妇太爽了快点再快点| 草草影院精品一区二区三区 | 丰满的少妇邻居中文bd| 色在线 | 国产| 高清欧美性猛交xxxx黑人猛交| 电影久久久久久| 欧美精品v国产精品v日韩精品 | 亚洲国产成人va在线观看天堂| 亚洲乱码一卡二卡卡3卡4卡| 国外亚洲成av人片在线观看| 女的被弄到高潮娇喘喷水视频| 学生妹无套内射正在播放| 国产日产精品一区二区三区四区的特点| 国外av无码精品国产精品| 欧洲熟妇色xxxxx视频| 久久精品99久久香蕉国产|