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  4. Recombinant Human Huntingtin-interacting protein 1-related protein (HIP1R), partial

Recombinant Human Huntingtin-interacting protein 1-related protein (HIP1R), partial

  • 中文名稱：
    人HIP1R重組蛋白
  • 貨號：
    CSB-YP010366HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HIP1R重組蛋白
  • 貨號：
    CSB-EP010366HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HIP1R重組蛋白
  • 貨號：
    CSB-EP010366HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HIP1R重組蛋白
  • 貨號：
    CSB-BP010366HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HIP1R重組蛋白
  • 貨號：
    CSB-MP010366HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HIP1R
  • Uniprot No.：
  • 別名：
    FLJ14000; FLJ27022; HIP-12; Hip1 related ; HIP1-related protein; HIP12; HIP1R; HIP1R_HUMAN; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12; ILWEQ; KIAA0655; MGC47513
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
  • 基因功能參考文獻：
    1. HIP1R rescued miR-23b/-27b-mediated repression of migration in prostate cancer cells. HIP1R mRNA levels were decreased in seminal vesicle tissue from mice bearing miR-23b/-27b-transduced prostate cancer cell xenografts compared with scrambled controls, suggesting HIP1R is a key functional target of miR-23b/-27b. PMID: 26898757
    2. our findings support the conclusion that the rs12817488 in CCDC62/HIP1R polymorphism may increase the risk of Parkinson's disease in the Chinese Han population. PMID: 25818163
    3. We conclude that HIP1R expression is strongly indicative of survival in diffuse large B-cell lymphoma PMID: 26341140
    4. STK39 (rs2102808) and CCDC62/HIP1R (rs12817488) do not appear to influence PD risk. PMID: 24312176
    5. HIP1r plays an important role in regulating the attachment of spindle microtubules to chromosomes during mitosis, an event that is required for accurate congression and segregation of chromosomes. PMID: 21189155
    6. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. (HIP12) PMID: 11889126
    7. both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains PMID: 14732715
    8. Hip1R has a role in making the interaction between actin and the endocytic machinery functional and transient PMID: 14742709
    9. The F-actin binding capacity of Hip12 is regulated by intrasteric occlusion of primary actin-binding determinants within the Hip12 I/LWEQ module. PMID: 15581353
    10. the stability of intergenerational transmission of a variable number tandem repeat (VNTR) polymorphism, found in the Huntingtin interacting protein-1 related gene (HIP12/HIP1R) that is mapped to the chromosome 12q24.31 region. PMID: 15588756
    11. characterize the F-actin-binding region of HIP1R, termed the talin-HIP1/R/Sla2p actin-tethering C-terminal homology (THATCH) domain PMID: 16415883
    12. Human HIP1 transgenic Hip1/Hip1r knockout mice are completely free from dwarfism and spinal defects. PMID: 17452370
    13. Neuronal dysfunction in transgenic Caenorhabditis elegans expressing mutant N-terminal huntingtin is specifically enhanced by hipr-1 loss of function. PMID: 17928447
    14. in mammalian cells CLCs function in intracellular membrane trafficking by acting as recruitment proteins for HIP1R, enabling HIP1R to regulate actin assembly on clathrin-coated structures PMID: 18165318
    15. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain PMID: 18790740
    16. This study provided the previously unknown function of HIP1R involved in the intrinsic cell death pathway and further explored possible mechanisms by which HIP1R induces cell death. PMID: 19255499

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  • 亞細胞定位：
    Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
  • 蛋白家族：
    SLA2 family
  • 組織特異性：
    Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
  • 數據庫鏈接：

    HGNC: 18415

    OMIM: 605613

    KEGG: hsa:9026

    STRING: 9606.ENSP00000253083

    UniGene: Hs.524815



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