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  4. Recombinant Human Huntingtin-interacting protein 1 (HIP1), partial

Recombinant Human Huntingtin-interacting protein 1 (HIP1), partial

  • 中文名稱：
    人HIP1重組蛋白
  • 貨號：
    CSB-YP010365HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HIP1重組蛋白
  • 貨號：
    CSB-EP010365HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HIP1重組蛋白
  • 貨號：
    CSB-EP010365HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HIP1重組蛋白
  • 貨號：
    CSB-BP010365HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HIP1重組蛋白
  • 貨號：
    CSB-MP010365HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP 1; HIP I; HIP-1; HIP-I; hip1; HIP1/PDGFRB fusion gene; HIP1/PDGFRB fusion gene, included; HIP1_HUMAN; HIPI; Huntingtin interacting protein 1; Huntingtin Interacting Protein HIP1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I; ILWEQ; KIAA4113; MGC126506; MGC27616; mKIAA4113
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
  • 基因功能參考文獻：
    1. HIP1 gene expression might serve as a reliable predictor for overall survival in acute myeloid leukemia patients. PMID: 28452374
    2. After HIP1 expression was blocked by siRNAs, EGFR endocytosis was accelerated and this effect was dependent on the EGF concentration. This endocytosis was colocalized with clathrin expression. These findings indicate that the inhibition of HIP1 can accelerate the endocytosis and degradation of EGFR PMID: 29039605
    3. Data suggest that GLP1R signaling in pancreatic beta-cells leading to insulin secretion involves interactions of GLP1R with HIP1, SNX1, and SNX27; HIP1 appears to regulate coupling of cell surface GLP1R activation with endocytosis; SNX1 and SNX27 appear to control balance between GLP1R plasma membrane recycling and lysosomal degradation. PMID: 29284659
    4. HIP1 deletion is not involved in Williams-Beuren syndrome. PMID: 26437767
    5. Huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis. metastasis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201412-2226OC#.V8DF69LrtNs PMID: 26595459
    6. SHON is a novel human oncogene with predictive utility in ER(+) breast cancer, perhaps offering a simple biomarker to predict the therapeutic efficacy of antiestrogen therapy in patients with breast cancer. PMID: 24296488
    7. SHON plays an important role in EMT and contributes to breast cancer progression. PMID: 25082541
    8. HIP1-ALK, a novel fusion protein is associated with lung adenocarcinoma. PMID: 24518094
    9. HIP1-ALK-rearranged tumor is sensitive to treatment with crizotinib, implicating HIP1-ALKas an oncogenic driver of lung tumorigenesis PMID: 24496003
    10. Identified a four-tyrosine "HIP1 phosphorylation motif" in the N-terminal region of HIP1 that is required for phosphorylation mediated by both EGFR and PDGFbetaR but not by the oncoproteins HIP1/PDGFbetaR (H/P), and TEL/PDGFbetaR (T/P). PMID: 23836884
    11. Three neuronal proteins (Huntingtin interacting protein 1, neurofascin, and olfactomedin-like 2a) are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. PMID: 22913984
    12. flexibility of the HIP1 coiled-coil domain is important for normal function and may lead to new insights into Huntington's disease PMID: 22835334
    13. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    14. Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit PMID: 21697888
    15. data characterize a neurodevelopmental and epilepsy syndrome that is likely caused by recurrent and nonrecurrent deletions, including HIP1 PMID: 21109226
    16. hydrogen-bond network and changes in coiled-coil monomer interaction suggest that the HIP1 coiled-coil domain is uniquely suited to allow conformational flexibility. PMID: 20179344
    17. Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway. PMID: 11788820
    18. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. PMID: 11889126
    19. huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival PMID: 12163454
    20. both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains. PMID: 14732715
    21. HIP1 has roles in endocytosis and receptor trafficking and in tumorigenesis PMID: 15059611
    22. roles of Hip1 and Hip1R in affecting clathrin assembly and actin distribution are mediated by their interaction with the conserved sequence of clathrin light chain PMID: 15533940
    23. The F-actin binding capacity of Hip1 is regulated by intrasteric occlusion of primary actin-binding determinants within the Hip1 I/LWEQ module. PMID: 15581353
    24. HIP1 is a nucleocytoplasmic protein capable of associating with membranes and DNA response elements and regulating transcription. PMID: 16027218
    25. neurotoxic signals of Hip1 transmit through the intrinsic mitochondrial apoptotic pathwaysand the formation of apoptosome complex PMID: 16979168
    26. Human HIP1 transgenic Hip1/Hip1r knockout mice are completely free from dwarfism and spinal defects. PMID: 17452370
    27. Crystal structure at 2.8 A of HIP1 coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI). PMID: 18155047
    28. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain PMID: 18790740
    29. Data demonstrate HIP1's role in pits maturation and formation of the coated vesicle, and its strong dependence on clathrin for membranal localization. PMID: 19626275

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  • 相關疾病：
    A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).
  • 亞細胞定位：
    Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
  • 蛋白家族：
    SLA2 family
  • 組織特異性：
    Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
  • 數據庫鏈接：

    HGNC: 4913

    OMIM: 601767

    KEGG: hsa:3092

    STRING: 9606.ENSP00000336747

    UniGene: Hs.329266



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