在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Humanin (MT-RNR2)

In Stock
  • 中文名稱:
    人MT-RNR2重組蛋白
  • 貨號:
    CSB-MP814209HU
  • 規格:
    ¥3960
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Humanin mitochondrial Short name: HNM
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    31.6 kDa
  • 表達區域:
    1-24aa
  • 氨基酸序列
    MAPRGFSCLLLLTSEIDLPVKRRA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal hFc1-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Also suppresses apoptosis by binding to BID and inhibiting the interaction of BID with BAX and BAK which prevents oligomerization of BAX and BAK and suppresses release of apoptogenic proteins from mitochondria. Forms fibers with BAX and also with BID, inducing BAX and BID conformational changes and sequestering them into the fibers which prevents their activation. Can also suppress apoptosis by interacting with BIM isoform BimEL, inhibiting BimEL-induced activation of BAX, blocking oligomerization of BAX and BAK, and preventing release of apoptogenic proteins from mitochondria. Plays a role in up-regulation of anti-apoptotic protein BIRC6/APOLLON, leading to inhibition of neuronal cell death. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death. Competes with importin KPNB1 for binding to IGFBP3 which is likely to block IGFBP3 nuclear import. Induces chemotaxis of mononuclear phagocytes via FPR2/FPRL1. Reduces aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPR2 to APP. Protects retinal pigment epithelium (RPE) cells against oxidative stress-induced and endoplasmic reticulum (ER) stress-induced apoptosis. Promotes mitochondrial biogenesis in RPE cells following oxidative stress and promotes STAT3 phosphorylation which leads to inhibition of CASP3 release. Also reduces CASP4 levels in RPE cells, suppresses ER stress-induced mitochondrial superoxide production and plays a role in up-regulation of mitochondrial glutathione. Reduces testicular hormone deprivation-induced apoptosis of germ cells at the nonandrogen-sensitive stages of the seminiferous epithelium cycle. Protects endothelial cells against free fatty acid-induced inflammation by suppressing oxidative stress, reducing expression of TXNIP and inhibiting activation of the NLRP3 inflammasome which inhibits expression of proinflammatory cytokines IL1B and IL18. Protects against high glucose-induced endothelial cell dysfunction by mediating activation of ERK5 which leads to increased expression of transcription factor KLF2 and prevents monocyte adhesion to endothelial cells. Inhibits the inflammatory response in astrocytes. Increases the expression of PPARGC1A/PGC1A in pancreatic beta cells which promotes mitochondrial biogenesis. Increases insulin sensitivity.
  • 亞細胞定位:
    Secreted. Cytoplasm. Cell projection, cilium, flagellum. Nucleus. Mitochondrion.
  • 蛋白家族:
    Humanin family
  • 組織特異性:
    Expressed in testis, seminal plasma and sperm (at protein level). Higher seminal plasma levels are associated with normospermia than with oligospermia, asthenospermia or oligoasthenospermia (at protein level). Higher sperm levels are associated with normo
  • 數據庫鏈接:

    HGNC: 7471

    OMIM: 606120



主站蜘蛛池模板: 国产美女被遭强高潮网站下载| 国产欧美日韩精品a在线观看| 野狼第一精品社区| 无套内谢少妇毛片aaaa片免费| 亚洲国产制服丝袜高清在线| 欧美日韩中文国产一区发布| 国内精品久久久久久中文字幕| 亚洲中文色欧另类欧美| 成人污污污www网站免费| 亚洲成a人无码| 久久久精品波多野结衣| 欧美日韩免费专区在线| 人妻精品久久无码区| 国产高清自产拍av在线| 亚洲国产成人精品无码区99| 久久精品国产99久久6动漫| 国产精华av午夜在线观看| 蜜臀av在线观看| 久久久婷婷五月亚洲97号色| 男女下面进入的视频| 人妻一区二区三区高清av专区| 中文无码av在线亚洲电影| 亚洲色欧美色2019在线| 8av国产精品爽爽ⅴa在线观看| 日韩精品亚洲aⅴ在线影院| 亚洲人色婷婷成人网站在线观看| 少妇久久久久久被弄到高潮 | 欧美精品亚洲精品日韩专区| 中国美女牲交视频| 亚洲精品久久久久久久久久久 | 久久精品亚洲男人的天堂| 久精品视频在线观看免费 | 女女女女女裸体开bbb| 日韩av无码中文无码不卡电影 | 亚洲精品久久久无码av片软件| 亚洲欧美日韩中文二区| 久久久久无码精品国产| 免费午夜爽爽爽www视频十八禁| 亚洲最新无码成av人| 欧美伊人色综合久久天天| 玩弄japan白嫩少妇hd小说|