在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Homeodomain-interacting protein kinase 1 (HIPK1), partial

  • 中文名稱:
    人HIPK1重組蛋白
  • 貨號:
    CSB-YP803159HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人HIPK1重組蛋白
  • 貨號:
    CSB-EP803159HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人HIPK1重組蛋白
  • 貨號:
    CSB-EP803159HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人HIPK1重組蛋白
  • 貨號:
    CSB-BP803159HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人HIPK1重組蛋白
  • 貨號:
    CSB-MP803159HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Hipk 1; Hipk1; HIPK1_HUMAN; Homeodomain interacting protein kinase 1; Homeodomain interacting protein kinase 1 like protein; Homeodomain-interacting protein kinase 1; Myak ; Nbak 2; Nbak2 ; Nuclear body associated kinase 2; Nuclear body associated kinase 2b
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
  • 基因功能參考文獻:
    1. HIPK1, HIPK2 and HIPK3 interact with the components of the carbon catabolite repressor 4 (CCR4)-negative on TATA (NOT) complex, an important regulator of all the major steps in the mRNA metabolism. it has emerged that HIPKs and their related miRNAs are involved in diabetic nephropathy, gastric cancer chemoresistance, cervical cancer progression, and recombinant protein expression in cultured cells. [Review] PMID: 29793420
    2. The data presented here con fi rmed that HIPK1 is involved in the increased expression of recombinant luciferase and the secreted recombinant GPC3-hFc from HEK 293 cells following transfection with miR-22-3p. PMID: 28987030
    3. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. PMID: 24559171
    4. HIPK1 drives p53 activation to limit colorectal cancer cell growth. PMID: 23676219
    5. HIPK1 and HIPK2, are transcriptional corepressors that regulate TGF-beta-dependent angiogenesis during embryonic development. PMID: 23565059
    6. HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear. PMID: 23071292
    7. TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation PMID: 15701637
    8. c-Myb appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data. PMID: 19646965

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Nucleus speckle.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, HIPK subfamily
  • 組織特異性:
    Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. Expressed in both androgen-dependent and androgen-independent prostate cancer cells.
  • 數據庫鏈接:

    HGNC: 19006

    OMIM: 608003

    KEGG: hsa:204851

    STRING: 9606.ENSP00000358571

    UniGene: Hs.532363



主站蜘蛛池模板: 无码av大香线蕉| 国产精品永久久久久久久久久| 国产精品∧v在线观看| 日本护士毛茸茸| 婷婷五月深深久久精品| 无码人妻一区二区三区一| 日本熟妇色一本在线观看| 亚洲一卡2卡3卡4卡5卡精品| 99在线精品视频观看免费| 欧美日韩色另类综合| 亚洲精品v天堂中文字幕| 国产美女被遭高潮免费网站| aⅴ亚洲 日韩 色 图网站 播放 | 亚洲国产av精品一区二区蜜芽| 成人免费无码av| 熟妇人妻无码xxx视频| 国产在线不卡人成视频| 一区二区和激情视频| 色婷婷一区二区三区四区成人网| 亚洲成av人片在一线观看| 中文字幕人妻av一区二区| 天堂网在线www中文| 成视频年人黄网站免费视频| 日本午夜免费福利视频| 国产末成年av在线播放| 性亚洲videofree高清| 99re久久精品国产| 欧美zozo另类特级| 日韩人妻不卡一区二区三区| 国产精品久久久久久人妻精品动漫 | 中文乱码字幕视频观看网站免费 | 亚洲第一福利网站在线观看| 天天躁日日躁狠狠躁欧美老妇小说 | 成人精品一区二区三区在线观看| 99久久久精品免费观看国产| 日本特黄特色特爽大片| 麻豆国产人妻欲求不满| 久久不见久久见免费视频观看| 一本色综合亚洲精品蜜桃冫| 亚洲成a人v影院色老汉影院| 白丝乳交内射一二三区|