在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HIPK1 Antibody, FITC conjugated

HIPK1 Antibody, FITC conjugated

  • 中文名稱：
    HIPK1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA803159LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HIPK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Hipk 1 antibody; Hipk1 antibody; HIPK1_HUMAN antibody; Homeodomain interacting protein kinase 1 antibody; Homeodomain interacting protein kinase 1 like protein antibody; Homeodomain-interacting protein kinase 1 antibody; Myak antibody; Nbak 2 antibody; Nbak2 antibody; Nuclear body associated kinase 2 antibody; Nuclear body associated kinase 2b antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Homeodomain-interacting protein kinase 1 protein (1007-1151AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
  • 基因功能參考文獻(xiàn)：
    1. HIPK1, HIPK2 and HIPK3 interact with the components of the carbon catabolite repressor 4 (CCR4)-negative on TATA (NOT) complex, an important regulator of all the major steps in the mRNA metabolism. it has emerged that HIPKs and their related miRNAs are involved in diabetic nephropathy, gastric cancer chemoresistance, cervical cancer progression, and recombinant protein expression in cultured cells. [Review] PMID: 29793420
    2. The data presented here con fi rmed that HIPK1 is involved in the increased expression of recombinant luciferase and the secreted recombinant GPC3-hFc from HEK 293 cells following transfection with miR-22-3p. PMID: 28987030
    3. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. PMID: 24559171
    4. HIPK1 drives p53 activation to limit colorectal cancer cell growth. PMID: 23676219
    5. HIPK1 and HIPK2, are transcriptional corepressors that regulate TGF-beta-dependent angiogenesis during embryonic development. PMID: 23565059
    6. HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear. PMID: 23071292
    7. TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation PMID: 15701637
    8. c-Myb appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data. PMID: 19646965

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Nucleus speckle.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, HIPK subfamily
  • 組織特異性：
    Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. Expressed in both androgen-dependent and androgen-independent prostate cancer cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19006

    OMIM: 608003

    KEGG: hsa:204851

    STRING: 9606.ENSP00000358571

    UniGene: Hs.532363



主站蜘蛛池模板： 人与嘼交av免费| 好硬好湿好爽再深一点动态图视频| 中文字幕乱码熟女人妻水蜜桃| 亚洲精品久久久久久一区二区| 亚洲精品国产av成拍色拍个| 久久精品亚洲乱码伦伦中文| 亚洲国产老鸭窝一区二区三区| 99精品国产一区二区三区不卡 | 日本国产成人国产在线播放| 欧美伊人色综合久久天天| 亚洲国产av一区二区三区| 精品国产一区二区三区四区五区 | 同性女女黄h片在线播放| 久久大香国产成人av| 男女性爽大片视频| 亚洲国产成人极品综合| 国产精品嫩草99av在线| 日韩在线不卡免费视频一区| 久久99精品久久久久久动态图| 国产成人亚洲精品无码电影| 亚洲中文超碰中文字幕| 亚洲成a人片在线观看无码| 欧美丰满大乳大屁股流白浆| 一卡二卡3卡4卡视频免费播放| 亚洲人成网站18禁止中文字幕 | 亚洲情a成黄在线观看| 爆乳女仆高潮在线观看| 一群黑人大战亚裔女在线播放| 被窝影院午夜无码国产| 欧美无遮挡很黄裸交视频| 精品一区二区三区免费视频| 最新的国产成人精品2022| 欧美两根一起进3p在线观看| 在线视频网站www色| 日韩精品无码一本二本三本| 在线看片免费人成视频国产片| 久久偷看各类wc女厕嘘嘘| 精国产品一区二区三区a片| 人妻影音先锋啪啪av资源| 大胸少妇午夜三级| 中文字幕在线亚洲精品|