在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Homeobox protein Nkx-3.2 (NKX3-2)

  • 中文名稱:
    人NKX3-2重組蛋白
  • 貨號:
    CSB-YP015849HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NKX3-2重組蛋白
  • 貨號:
    CSB-EP015849HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NKX3-2重組蛋白
  • 貨號:
    CSB-BP015849HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NKX3-2重組蛋白
  • 貨號:
    CSB-MP015849HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    NKX3-2
  • Uniprot No.:
  • 別名:
    Bagpipe homeobox 1; Bagpipe homeobox homolog 1; Bagpipe homeobox protein homolog 1; Bagpipe homeobox; Drosophila; homolog of; 1; BAPX 1; Homeobox protein NK-3 homolog B; Homeobox protein Nkx 3.2; Homeobox protein Nkx-3.2; MGC138171; NK3 homeobox 2; NKX3 2; NKX3-2; NKX3.2; NKX3.2; mouse; homolog of; NKX32_HUMAN; NKX3B; OTTHUMP00000115816; SMMD
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-333
  • 氨基酸序列
    MAVRGANTLT SFSIQAILNK KEERGGLAAP EGRPAPGGTA ASVAAAPAVC CWRLFGERDA GALGGAEDSL LASPAGTRTA AGRTAESPEG WDSDSALSEE NESRRRCADA RGASGAGLAG GSLSLGQPVC ELAASKDLEE EAAGRSDSEM SASVSGDRSP RTEDDGVGPR GAHVSALCSG AGGGGGSGPA GVAEEEEEPA APKPRKKRSR AAFSHAQVFE LERRFNHQRY LSGPERADLA ASLKLTETQV KIWFQNRRYK TKRRQMAADL LASAPAAKKV AVKVLVRDDQ RQYLPGEVLR PPSLLPLQPS YYYPYYCLPG WALSTCAAAA GTQ
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
  • 基因功能參考文獻:
    1. NKL homeobox gene NKX2-5 was activated by NKX3-2 in CCRF-CEM and by FOXG1 in PEER, representing mutually inhibitory activators of this translocated oncogene. PMID: 29746601
    2. post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. PMID: 27312341
    3. Bapx1 indicates poor prognosis for gastric cancer patients by promoting tumor migration and invasion via TGF-beta-induced epithelial-mesenchymal transition. PMID: 28315334
    4. PI3K-mediated suppression of Nkx3.2 in chondrocytes plays a role in the control of cartilage hypertrophy during skeletal development in vertebrates. PMID: 26363466
    5. Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte. PMID: 26245691
    6. Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation PMID: 22507129
    7. Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha. PMID: 21606193
    8. NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans PMID: 20004766
    9. Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9. PMID: 15024065

    顯示更多

    收起更多

  • 相關疾病:
    Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    NK-3 homeobox family
  • 組織特異性:
    Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.
  • 數據庫鏈接:

    HGNC: 951

    OMIM: 602183

    KEGG: hsa:579

    STRING: 9606.ENSP00000371875

    UniGene: Hs.590927



主站蜘蛛池模板: 无码人妻一区二区三区在线| 亚洲国产精品久久久久秋霞小说| 日韩高清在线观看永久| 国产人妻久久精品一区二区三区 | 日本大片免费观看视频| 白嫩少妇激情无码| 好爽…又高潮了毛片免费看| 337人体做爰大胆视频| 亚洲精品综合在线影院| 国产精品成人99久久久久| 麻豆av一区二区三区| 国产精品无码mv在线观看| www激情内射在线看| 精品国产日韩亚洲一区| 里番本子纯肉侵犯肉全彩无码| 午夜精品久久久久久久久| 人妻一区二区三区高清av专区| 国产99在线 | 中国| 农民人伦一区二区三区| 最近免费中文字幕中文高清百度 | 人人妻人人爽日日人人| 日本在线视频www鲁啊鲁| 中文字幕日韩精品一区二区三区| 精品麻豆国产色欲色欲色欲www| 九九99精品久久久久久综合| 国产精品涩涩涩视频网站| 麻豆av一区二区三区久久| 2020精品国产午夜福利在线观看| 成人伊人青草久久综合网| 久久国语露脸国产精品电影| 欧美又大又粗午夜剧场免费| 爆乳高潮喷水无码正在播放| 免费裸体无遮挡黄网站免费看| 精品久久久久久无码专区不卡| 亚洲大尺度无码无码专线| 欧美成人午夜免费影院手机在线看| 久久天天躁狠狠躁夜夜avapp| 精品熟女少妇a∨免费久久| 国产69精品久久久久孕妇| 久久不见久久见免费视频7| 国产乱子经典视频在线观看 |