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  4. NKX3-2 Antibody, HRP conjugated

NKX3-2 Antibody, HRP conjugated

  • 中文名稱：
    NKX3-2兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA015849LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NKX3-2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NKX3-2
  • 別名：
    Bagpipe homeobox 1 antibody; Bagpipe homeobox homolog 1 antibody; Bagpipe homeobox protein homolog 1 antibody; Bagpipe homeobox; Drosophila; homolog of; 1 antibody; BAPX 1 antibody; Homeobox protein NK-3 homolog B antibody; Homeobox protein Nkx 3.2 antibody; Homeobox protein Nkx-3.2 antibody; MGC138171 antibody; NK3 homeobox 2 antibody; NKX3 2 antibody; NKX3-2 antibody; NKX3.2 antibody; NKX3.2; mouse; homolog of antibody; NKX32_HUMAN antibody; NKX3B antibody; OTTHUMP00000115816 antibody; SMMD antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein Nkx-3.2 protein (1-333AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
  • 基因功能參考文獻：
    1. NKL homeobox gene NKX2-5 was activated by NKX3-2 in CCRF-CEM and by FOXG1 in PEER, representing mutually inhibitory activators of this translocated oncogene. PMID: 29746601
    2. post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. PMID: 27312341
    3. Bapx1 indicates poor prognosis for gastric cancer patients by promoting tumor migration and invasion via TGF-beta-induced epithelial-mesenchymal transition. PMID: 28315334
    4. PI3K-mediated suppression of Nkx3.2 in chondrocytes plays a role in the control of cartilage hypertrophy during skeletal development in vertebrates. PMID: 26363466
    5. Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte. PMID: 26245691
    6. Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation PMID: 22507129
    7. Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha. PMID: 21606193
    8. NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans PMID: 20004766
    9. Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9. PMID: 15024065

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  • 相關疾病：
    Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    NK-3 homeobox family
  • 組織特異性：
    Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.
  • 數據庫鏈接：

    HGNC: 951

    OMIM: 602183

    KEGG: hsa:579

    STRING: 9606.ENSP00000371875

    UniGene: Hs.590927



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