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  4. Recombinant Human Homeobox protein Hox-A11 (HOXA11)

Recombinant Human Homeobox protein Hox-A11 (HOXA11)

  • 中文名稱：
    人HOXA11重組蛋白
  • 貨號：
    CSB-YP010649HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HOXA11重組蛋白
  • 貨號：
    CSB-EP010649HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HOXA11重組蛋白
  • 貨號：
    CSB-EP010649HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HOXA11重組蛋白
  • 貨號：
    CSB-BP010649HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HOXA11重組蛋白
  • 貨號：
    CSB-MP010649HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXA11
  • Uniprot No.：
  • 別名：
    Homeo box 1I; Homeo box A11 ; Homeobox A11; Homeobox protein Hox A11; Homeobox protein Hox-1I; Homeobox protein Hox-A11; Homeobox protein HOXA11; Hox 1I; HOX1; HOX1I ; HOXA11; HXA11_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-313
  • 氨基酸序列
    MDFDERGPCS SNMYLPSCTY YVSGPDFSSL PSFLPQTPSS RPMTYSYSSN LPQVQPVREV TFREYAIEPA TKWHPRGNLA HCYSAEELVH RDCLQAPSAA GVPGDVLAKS SANVYHHPTP AVSSNFYSTV GRNGVLPQAF DQFFETAYGT PENLASSDYP GDKSAEKGPP AATATSAAAA AAATGAPATS SSDSGGGGGC RETAAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSSGQR TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN RDRLQYYSAN PLL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻：
    1. we uncovered a novel potential regulatory mechanism between HOTTIP and one of its physical HOXA clusters, HOXA11. Hence, HOTTIP may mediate, at least partly, HOXA11 expression involved in cell growth, migration, and apoptosis of breast cancer MCF-7 cells. PMID: 29415429
    2. High expression of lncRNA HOXA11-AS promotes breast cancer invasion and metastasis by affecting EMT. PMID: 28701685
    3. HOXA11 silencing suppressed osteosarcoma cell proliferation, invasion and induced cell arrest. PMID: 28558357
    4. Results show that aberrant hypermethylation and the methylation-induced down-regulation of HOXA11 may promote lung adenocarcinoma progression. PMID: 28380439
    5. Hypermethylation of HOXA11 is an independent prognostic biomarker in breast cancer. Suggest HOXA11 as a potential tumor suppressor. PMID: 28038461
    6. The treatment resistance induced by the underexpression of HOXA11 can contribute to a poor prognosis in GBM. PMID: 27456940
    7. These results suggest that mutations in the coding sequence of HOXA11 might not be a common cause of cryptorchidism, while common polymorphisms in the HOXA11 gene might contribute to the risk of developing unilateral cryptorchidism. PMID: 28261830
    8. demonstrated that HOXA11-antisense(AS) functioned as a molecular sponge for miR-124, and overexpression of miR-124 attenuated the proliferation and invasion-promoting effect of HOXA11-AS PMID: 28749709
    9. Bioinformatics prediction forecast that miR-140-5p directly targeted HOXA11-antisense RNA at 3'-UTR, which was confirmed by luciferase reporter assay PMID: 28832185
    10. HOXA11-AS functions as a competing endogenous RNA. PMID: 29034803
    11. our study demonstrated that HOXA11 function as a tumor suppressor in renal cell carcinoma PMID: 28423531
    12. Laparoscopic endometrioma resection increases peri-implantation endometrial HOXA-11 mRNA expression. PMID: 26056923
    13. Epigenetic silencing of HOXA11 promotes gastric cancer proliferation, migration and invasion through activation of Wnt signaling. PMID: 25590359
    14. The overexpression of miR-30d or 181a suppressed HOXA11 mRNA. PMID: 25630974
    15. Low HOXA11 expression is associated with hepatocellular carcinoma. PMID: 24306662
    16. Mutations in the coding region of HOXA11 are not common in Chinese women with Mullerian duct anomalies. PMID: 24745830
    17. Study suggests that HOXA11 hypermethylation may contribute to the progression of NSCLC by promoting cell proliferation or migration. PMID: 24259349
    18. Lower expression of HOXA11 is associated with endometriosis-associated infertility. PMID: 23979130
    19. Promoter methylation of HOXA11 is associated with glioblastoma. PMID: 23624749
    20. reduced HOXA11 expression may contribute to endometriosis-associated infertility PMID: 22233680
    21. Endometrial HOXA11 and LIF mRNA expression levels (normalized to beta-actin expression) were significantly decreased in endometrium of infertile patients with endometriosis compared with healthy fertile controls PMID: 21987111
    22. The result suggest that HOXA-11 gene expression in the endometrium during the implantation window may not be altered in patients with idiopathic infertility. PMID: 21526497
    23. Expression of HOXA11 represses the expression of p53 in uterosacral ligaments. PMID: 19372592
    24. Our results suggest that altered HOXA11 gene expression in the endometrium during a menstrual cycle may be a common phenomenon among patients with endometriosis and may cause infertility in this group of patients PMID: 20695189
    25. NUP98 primer and a degenerate primer corresponding to the third helix of the homeodomain of HOXA demonstrated that NUP98 was fused in-frame to HOXA11 in the patient with CML ( chronic myelogenous leukemia) PMID: 11830496
    26. expressed in the developing kidney PMID: 12060755
    27. HOXA gene expression is up-regulated at the ectopic implantation site in the fallopian tube and it may play a role in ectopic pregnancies. PMID: 15167850
    28. study reveals a novel expression pattern for homeo box A11(HOXA11) gene in human endometrium PMID: 15467538
    29. The HOXA11 gene cluster is in T-cell malignancies resulting in deregulated HOXA gene expression and is in keeping with a previous report suggesting HOXA deregulation in MLL-rearranged T cell lymphoblastic leukemia. PMID: 15674412
    30. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. PMID: 18274672
    31. Our findings do not support the hypothesis that mutations in the HOXA11 coding regions are involved in the pathogenesis of human non-syndromal congenital renal parenchymal malformations. PMID: 19255789
    32. Methylation of HOXA11 gene is associated with high-grade squamous intraepithelial lesions in cervical cancer PMID: 19609949

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  • 相關疾病：
    Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 (RUSAT1)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5101

    OMIM: 142958

    KEGG: hsa:3207

    STRING: 9606.ENSP00000006015

    UniGene: Hs.249171



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