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  4. Recombinant Human Homeobox protein DLX-1 (DLX1)

Recombinant Human Homeobox protein DLX-1 (DLX1)

  • 中文名稱：
    人DLX1重組蛋白
  • 貨號：
    CSB-YP006952HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DLX1重組蛋白
  • 貨號：
    CSB-EP006952HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DLX1重組蛋白
  • 貨號：
    CSB-EP006952HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DLX1重組蛋白
  • 貨號：
    CSB-BP006952HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DLX1重組蛋白
  • 貨號：
    CSB-MP006952HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DLX1
  • Uniprot No.：
  • 別名：
    DII B; Distal less homeo box 1; Distal less homeobox 1; Distal-less homeobox gene 1a; Dlx 1; Dlx; Dlx1; Dlx1 distal-less homeobox 1; DLX1_HUMAN; Homeo box protein DLX1; Homeobox protein DLX 1; Homeobox protein DLX-1; Homeobox protein Dlx1a; Homeodomain transcription factor DLX1 ; MGC189409; OTTHUMP00000082494; OTTHUMP00000082497; OTTMUSP00000014202; RP23-419H3.3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-255
  • 氨基酸序列
    MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR SKFKKLMKQG GAALEGSALA NGRALSAGSP PVPPGWNPNS SSGKGSGGNA GSYIPSYTSW YPSAHQEAMQ QPQLM
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
  • 基因功能參考文獻：
    1. observations suggest that altered DLX1 methylation and expression contribute to pathogenesis of PSP by influencing MAPT. PMID: 30050033
    2. Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes. PMID: 28131910
    3. DLX1 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
    4. these data strongly suggest that DLX1 has a pivotal role in FOXM1 signaling to promote cancer aggressiveness through intensifying TGF-beta/SMAD4 signaling in high-grade serous ovarian cancer cells. PMID: 27593933
    5. TDT results showed an association between DLX1 and cleft lip and palate, in which the A allele was undertransmited (p=0.022). PMID: 25463899
    6. The study data demonstrate an association between SNP rs7888172 of the DLX1 gene and non-syndromic hypodontia in Chinese Han individuals. PMID: 22984994
    7. The regulation of fate switch between cortical and striatal interneurons is dependent on Dlx1 (and Dlx2). PMID: 23312518
    8. These findings suggest that alterations in DLX1/2 contribute to the biological consequences of FLT3 activation. PMID: 21357706
    9. DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production PMID: 14671321
    10. The DLX1 and DLX2 genes lie head-to-head in 2q32; the findings support the presence of two functional polymorphisms, one in or near each of the DLX genes that increase susceptibility to, or cause, autism. PMID: 18728693

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Distal-less homeobox family
  • 組織特異性：
    Expressed in hematopoietic cell lines.
  • 數據庫鏈接：

    HGNC: 2914

    OMIM: 600029

    KEGG: hsa:1745

    STRING: 9606.ENSP00000354478

    UniGene: Hs.407015



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