在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Histone-lysine N-methyltransferase ASH1L (ASH1L), partial

Recombinant Human Histone-lysine N-methyltransferase ASH1L (ASH1L), partial

  • 中文名稱：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 貨號：
    CSB-YP865114HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 貨號：
    CSB-EP865114HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 貨號：
    CSB-EP865114HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 貨號：
    CSB-BP865114HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 貨號：
    CSB-MP865114HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ASH1L
  • Uniprot No.：
  • 別名：
    Absent small and homeotic disks protein 1 homolog; Absent Small or Homeotic Like ; Absent Small or Homeotic Like; ASH 1; ASH 1L; ash1 (absent small or homeotic 1); Ash1 (absent small or homeotic) like; ASH1-like protein; ASH1L; ASH1L_HUMAN; ASH1L1; FLJ10504; huASH1; KIAA1420; KMT2H / ASH1; Lysine N-methyltransferase 2H; Probable histone-lysine N-methyltransferase ASH1L
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.
  • 基因功能參考文獻(xiàn)：
    1. DDB2 promotes cyclobutane pyrimidine dimer excision by recruiting the histone methyltransferase ASH1L, which methylates lysine 4 of histone H3. In turn, methylated H3 facilitates the docking of the XPC complex to nucleosomal histone octamers. PMID: 29109511
    2. suppresses matrix metalloproteinase through mitogen-activated protein kinase signaling pathway in pulpitis PMID: 28041684
    3. There has been increasing evidence that heterozygous mutation of ASH1L is associated with ID and autism spectrum disorders. We suggest that ASH1L abnormalities may cause a novel MCA/ID syndrome. PMID: 28394464
    4. Epigenetic regulators play vital roles in cancer pathogenesis and represent a new frontier in therapeutic targeting. Our studies provide basic mechanistic insight into the role of H3K36me2 in transcription activation and MLL leukemia pathogenesis and implicate ASH1L histone methyltransferase as a promising target for novel molecular therapy. PMID: 27154821
    5. Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta-thalassaemia severity. PMID: 27434206
    6. Structural features were identified in ASH1L related to its' function and enzymatic activity. PMID: 26292256
    7. Both ASH1L and SETD2 are H3K36 specific methyltransferases but only SETD2 can trimethylate this mark. PMID: 26002201
    8. These data demonstrate that miR-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1. PMID: 25238203
    9. Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb silencing PMID: 24244179
    10. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A. PMID: 24019522
    11. induction of Cdk5 activity is a novel mechanism through which hASH1 may regulate migration in lung carcinogenesis PMID: 22696682
    12. Long Non-coding RNA, DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. PMID: 22541069
    13. ASH1 and MLL1 synergize in activation of Hox genes. PMID: 22140534
    14. human ASH1L specifically methylates histone H3 Lys-36. PMID: 21239497
    15. These data suggest that ASH1L occupies most, if not all, active genes and methylates histone H3 in a nonredundant fashion at a subset of genes. PMID: 17923682

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cell junction, tight junction. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
  • 組織特異性：
    Widely expressed, with highest level in brain, heart and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19088

    OMIM: 607999

    KEGG: hsa:55870

    STRING: 9606.ENSP00000376204

    UniGene: Hs.491060



主站蜘蛛池模板： 亚洲一区精品无码色成人| 久久影院九九被窝爽爽| 国产超碰人人做人人爽av| 国产精品青青青在线观看| 熟妇的奶头又大又长奶水视频| 日韩av无码免费播放| 丁香色婷婷国产精品视频| 成人亚洲欧美在线观看| 免费大片av手机看片不卡| 国产区精品福利在线社区| 无码毛片视频一区二区本码| 丰满少妇人妻久久久久久| 九九热线精品视频16| 国产精品亚洲а∨无码播放不卡| 搡老熟女国产| 欧美老熟妇又粗又大| 久久亚洲精品情侣| 爆乳喷奶水无码正在播放 | 日躁夜躁狠狠躁2001| 浪荡女天天不停挨cao日常视频| 日产精品99久久久久久| 国产午夜精品一区二区三区四区| 亚洲经典三级| 国产成人av激情在线播放| 天天综合色天天综合色hd| 日韩欧美猛交xxxxx无码| 亚洲欧美日本国产专区一区 | 艳妇臀荡乳欲伦交换h在线观看| 国产xxxx做受性欧美88| 内射小寡妇无码| 国产成人小说视频在线观看| 无码国产精品一区二区免费i6 | 人人人爽人人爽人人av| 免费看国产zzzwww色| 无码人妻久久久一区二区三区| 欧美亅性猛交内射| 精品国产肉丝袜久久| 国产亚洲精品俞拍视频| 麻豆文化传媒精品一区观看| 国产一区丝袜高跟鞋| 日本不卡一区|