在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A)

Recombinant Human High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A)

  • 中文名稱：
    人PDE7A重組蛋白
  • 貨號：
    CSB-YP618810HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PDE7A重組蛋白
  • 貨號：
    CSB-EP618810HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PDE7A重組蛋白
  • 貨號：
    CSB-EP618810HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PDE7A重組蛋白
  • 貨號：
    CSB-BP618810HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PDE7A重組蛋白
  • 貨號：
    CSB-MP618810HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PDE7A
  • Uniprot No.：
  • 別名：
    5''-cyclic phosphodiesterase 7A; HCP 1; HCP1; High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A; High affinity cAMP-specific 3''; P2A; PDE 7; PDE 7A; PDE1/PDE2 yeast human complement of; PDE7; PDE71; PDE7A; PDE7A_HUMAN; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; Phosphodiesterase7A; Rolipram insensitive phosphodiesterase type 7 ; TM 22; TM22
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length of Isoform PDE7A2
  • 表達區域：
    1-456
  • 氨基酸序列
    MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
  • 基因功能參考文獻：
    1. Low PDE7A expression is associated with sepsis. PMID: 28356347
    2. PDE7A is a high-speed and low-affinity phosphodiesterase for cCMP. PMID: 25128584
    3. PDE7 has roles in regulating oligodendrocyte precursor survival and differentiation during brain development and in adulthood PMID: 23661015
    4. PDE7 has the potential to regulate human T cell function including cytokine production, proliferation and expression of activation markers. PMID: 12067300
    5. Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells; PDE7A was expressed in neutrophils and alveolar macrophages PMID: 12388353
    6. crystal structure of PDE7A1 catalytic domain complexed with the inhibitor 3-isobutyl-1-methylxanthine & kinetic analysis on mutant PDE7A1 and PDE4D2; results show several residues must work together to switch inhibitor selectivity between PDE4 & PDE7 PMID: 15994308
    7. results show that specific gene silencing with the RNAi method is a useful tool for inhibiting the gene expression of specific PDEs and that PDE7 silencing upregulates several osteogenic genes and increases mineralization PMID: 18420479

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform PDE7A1]: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.; [Isoform PDE7A2]: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE7 subfamily
  • 組織特異性：
    PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
  • 數據庫鏈接：

    HGNC: 8791

    OMIM: 171885

    KEGG: hsa:5150

    STRING: 9606.ENSP00000385632

    UniGene: Hs.527119



主站蜘蛛池模板： 久久综合精品无码av一区二区三区| 国产av午夜精品一区二区三| 精品女同一区二区| 亚洲一区二区三区高清av| 美女极度色诱视频国产免费| 激情97综合亚洲色婷婷五| 天天摸夜夜添狠狠添婷婷| 精品成在人线av无码免费看| 久久精品国产99国产精品导航 | 中文字幕乱偷无码av先锋| 9l国产精品久久久久尤物| 亚洲中文字幕在线第二页| 欧美乱人伦视频在线| 亚洲人ⅴsaⅴ国产精品| 人妻奶水人妻系列| 久久一本久综合久久爱| av第一福利网站| 亚洲人成电影网站色www| 国产精品无码无卡无需播放器| 国产成人av国语在线观看| 日日摸处处碰夜夜爽| 国内精品自在自线| 亚洲欧洲∨国产一区二区三区| 亚洲欧美偷拍另类a∨| 国产萌白酱喷水视频在线观看| 色婷婷av99xx| 99久久国产精品免费高潮| 成人精品免费视频在线观看| 亚洲肥老太bbw中国熟女| 欧美人与动牲交a欧美精品| 久久影院九九被窝爽爽| 国产精品高潮呻吟av久久黄| 精品少妇爆乳无码av无码专区| 国产网友自拍在线视频| 5x性社区免费视频播| 天天爽天天狠久久久综合麻豆| 99久久亚洲精品日本无码| 精品久久久久久亚洲综合网| 久久精品成人免费国产片小草| 色欲网天天无码av| 人人妻人人澡人人爽人人精品av|