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  4. Recombinant Human Hermansky-Pudlak syndrome 3 protein (HPS3), partial

Recombinant Human Hermansky-Pudlak syndrome 3 protein (HPS3), partial

  • 中文名稱：
    人HPS3重組蛋白
  • 貨號：
    CSB-YP856884HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HPS3重組蛋白
  • 貨號：
    CSB-EP856884HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HPS3重組蛋白
  • 貨號：
    CSB-EP856884HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HPS3重組蛋白
  • 貨號：
    CSB-BP856884HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HPS3重組蛋白
  • 貨號：
    CSB-MP856884HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HPS3
  • Uniprot No.：
  • 別名：
    HPS3; Hermansky-Pudlak syndrome 3 protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in early stages of melanosome biogenesis and maturation.
  • 基因功能參考文獻：
    1. HPS3 mutation is associated with high hypopigmentation in Hermansky-Pudlak syndrome. PMID: 27593200
    2. Description of mutations in HPS genes that cause Hermansky-Pudlak syndrome (review) PMID: 12125811
    3. HPS4 but not HPS3 associates with HPS1 in a complex, which we term biogenesis of lysosome-related organelles complex 3 (BLOC-3) PMID: 12847290
    4. A specific subset of melanocyte proteins are aberrantly trafficked throughout the HPS-3 melanocyte and may be responsible for the reduction in melanin synthesis. PMID: 15632015
    5. HPS3 associates with clathrin, predominantly on small clathrin-containing vesicles in the perinuclear region. This association most likely occurs directly via a functional clathrin-binding domain in HPS3. PMID: 16159387
    6. mutational analysis in Ashkenazi Jews with Hermansky-Pudlak syndrome 3 PMID: 11590544

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  • 相關疾病：
    Hermansky-Pudlak syndrome 3 (HPS3)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytosol.
  • 組織特異性：
    Widely expressed. Higher levels of expression are observed in kidney, liver and placenta.
  • 數據庫鏈接：

    HGNC: 15597

    OMIM: 606118

    KEGG: hsa:84343

    STRING: 9606.ENSP00000296051

    UniGene: Hs.558314



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