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  4. Recombinant Human Hephaestin (HEPH), partial

Recombinant Human Hephaestin (HEPH), partial

  • 中文名稱：
    人HEPH重組蛋白
  • 貨號：
    CSB-YP010289HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HEPH重組蛋白
  • 貨號：
    CSB-EP010289HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HEPH重組蛋白
  • 貨號：
    CSB-EP010289HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HEPH重組蛋白
  • 貨號：
    CSB-BP010289HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HEPH重組蛋白
  • 貨號：
    CSB-MP010289HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HEPH
  • Uniprot No.：
  • 別名：
    CPL; Heph; HEPH_HUMAN; Hephaestin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
  • 基因功能參考文獻：
    1. This review describes function of hephaestin as ferroxidase is essential for iron binding to apotransferrin in the lamina propria of the intestinal mucosa, a process that is important for further transport of iron to the liver by the portal vein. PMID: 24988611
    2. Iron efflux from human brain microvasculature endothelial cells ferroportin requires the action of an exocytoplasmic ferroxidase which can be either endogenous hephaestin or extracellular ceruloplasmin. PMID: 23640881
    3. Heph is active in placenta but may not play a key role in placental iron transport. PMID: 22170436
    4. These results support the hypothesis that hephaestin is involved in iron mobilization of iron from the intestine to circulation. PMID: 22503983
    5. In contrast to ceruloplasmin, hephaestin was incapable of direct oxidation of adrenaline and dopamine implying a difference in biological substrate specificities between these two homologous ferroxidases. PMID: 21802403
    6. Hephaestin is expressed in enterocytes, in the antral portion of the stomach, in the myenteric and submucous plexi, and in pancreatic beta-cells. PMID: 20019163
    7. location was observed on or near the cell surface suggesting it might participate in surface membrane transport of iron PMID: 11891802
    8. The gene structure, spanning approximately 100 kb, was assembled from the cDNA clones and the chromosome X genomic sequence data. Modelling supports its role as a membrane-tethered ferroxidase. PMID: 11932491
    9. The hephaestin protein mRNA expression is not significantly altered by variations in iron homeostasis. The effect of phlebotomy-induced erythropoiesis did not alter either gene transcript mRNA expression. PMID: 16137899
    10. Reombinant hephaestin was shown to have both multicopper oxidase and ferroxidase activity. PMID: 16274220
    11. Results suggest the possibility that FPN-1 might associate and interact with Heph in the process of iron exit across the basolateral membrane of intestinal absorptive cell. PMID: 17486601
    12. stable complex between these Cp and Hp and Tf does not occur under the experimental conditions used PMID: 18022819
    13. Repletion of copper in Caco2 cells leads to reconstitution of hephaestin protein expression, activity, and transepithelial iron transport. PMID: 19452451

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Multicopper oxidase family
  • 組織特異性：
    Detected in breast, colon, bone trabecular cells and fibroblasts.
  • 數據庫鏈接：

    HGNC: 4866

    OMIM: 300167

    KEGG: hsa:9843

    STRING: 9606.ENSP00000430620

    UniGene: Hs.31720



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