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Recombinant Human Hematopoietically-expressed homeobox protein HHEX (HHEX HEX PRH PRHX)

  • 中文名稱:
  • 貨號:
    CSB-YP010335HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP010335HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP010335HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP010335HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP010335HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    HHEX
  • Uniprot No.:
  • 別名:
    Hematopoietically-expressed homeobox protein HHEX; Homeobox protein HEX; Homeobox protein PRH; Proline-rich homeodomain protein; HHEX HEX PRH PRHX
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. May play a role in hematopoietic differentiation.
  • 基因功能參考文獻:
    1. HHEX is expressed in multiple types of acute myeloid leukemia (AML), with the highest levels seen in t(8;21) AML. PMID: 29263042
    2. The SNPs in TCF7L2 and HHEX were genotyped by polymerase chain reaction-restriction fragment length polymorphism. There were no significant differences in the distribution of genotypes and alleles between polycystic ovary syndrome cases and controls PMID: 26563606
    3. Two differentiation-related genes, HHEX and HLX, are promoters of early phase reprogramming toward pluripotency. PMID: 27335261
    4. This finding highlights the potentially functional alteration with HHEX rs1111875 and rs7923837 polymorphisms may increase colorectal cancer susceptibility. PMID: 27105501
    5. The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .The HHEX gene rs5015480 C allele may be a risk allele of GDM that is associated with increased BMI during pregnancy PMID: 27684496
    6. Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism. PMID: 28927755
    7. HHEX over expression induced by human cytomegalovirus infection closely associated with vascular proliferative diseases. PMID: 27965937
    8. The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX. PMID: 27377502
    9. These studies identify uPA-dependent de-repression of vegfr1 and vegfr2 gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF and identifies a potential new target for control of pathologic angiogenesis. PMID: 27151212
    10. Low HHEX mutation is associated with Thyroid Dysgenesis. PMID: 26757609
    11. Data suggest that hematopoietically expressed homeobox protein (HHEX) downmodulation by promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein (PML-RARalpha) is a key event during acute promyelocytic leukemia (APL) pathogenesis. PMID: 27052408
    12. Hhex binds to the Cdkn2a locus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression PMID: 26728554
    13. Data suggest that Hhex is a novel regulator of c-Myc function that limits c-Myc activity in transformed cells. PMID: 25220416
    14. PRH controls the migration of multiple epithelial cell lineages in part at least through the direct transcriptional regulation of Endoglin PMID: 24240683
    15. HHEX promotes hepatic specification by repressing EOMES expression. PMID: 24651531
    16. Data indicate the potential importance of CDKAL1 protein and homeobox protein HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of type 2 diabetes (T2D). PMID: 24112421
    17. In all the CHD patients, we did not find any causative mutations in the coding region of the HHEX gene. PMID: 23929257
    18. Tissue-specific knockdown of the HHEX ortholog dHHEX (CG7056) directed metabolic defects and enhanced lethality; for example, fat-body-specific loss of dHHEX led to increased hemolymph glucose and reduced insulin sensitivity PMID: 23445342
    19. In conclusion, this epistatic interaction showed a high degree of consistency when stratifying by sex, the epsilon4 allele of apolipoprotein E genotype, and geographic region. PMID: 23036584
    20. Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight. PMID: 23349771
    21. A significant association of rs1111875, rs5015480 and rs7923837 in HHEX gene with type 2 diabetes. PMID: 23166797
    22. Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). PMID: 22923468
    23. None of the 12 SNPs in the six genes (KCNJ11, TCF7L2, SLC30A8, HHEX, FTO and CDKAL1) uncovered in the genome-wide association studies were associated with polycystic ovary syndrome. PMID: 22443257
    24. re-establishment of gene control by PRH is in part responsible for the therapeutic effects of dasatinib. PMID: 22874537
    25. Genetic variants of the IDE-KIF11-HHEX region at 10q23.33 contribute to type 2 diabetes susceptibility. PMID: 22506066
    26. Loss of HHEX is associated with colorectal cancer. PMID: 21656028
    27. The proline rich homeodomain protein PRH/Hhex forms predominantly octameric and/or hexadecameric species in solution as well as larger assemblies. PMID: 22540015
    28. The associations between SNPs of TCF7L2, CDKAL1, SLC30A8 and HHEX and the development of DR and DN. PMID: 22487833
    29. HHEX, is more likely to represent the genuine signals of T2DM in the Tunisian population. PMID: 21510814
    30. Single nucleotide polymorphism (SNP) analysis revealed that the sequence variant (rs5015480) near HHEX and two SNPs (rs7756992 and rs9465871) in CDKAL1 were associated with the susceptibility of type 2 diabetes mellitus in females, but not in males. PMID: 21368910
    31. HHEX, IDE and SLC30A8 showed strongest tissue-specific mRNA expression bias and are associated with increased risk of type 2 diabete. PMID: 20703447
    32. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20879858
    33. Our data indicate that common genetic variants in two genes previously related to obesity (FTO) and diabetes (HHEX) by genome-wide association scans were not associated with endometrial cancer risk. PMID: 20647405
    34. Data report a novel association between the fetal ADCY5 type 2 diabetes risk allele and decreased birthweight, and confirm in meta-analyses associations between decreased birthweight and the type 2 diabetes risk alleles of HHEX-IDE and CDKAL1. PMID: 20490451
    35. Type 2 diabetes susceptibility alleles at HHEX are associated with low body mass index at 8 years in children who were born large for gestational age. PMID: 20460429
    36. There was no association of the genetic polymorhism rs1111875 of HHEX with the occurrence of polycystic ovary syndrome in the Chinese population. PMID: 20041287
    37. PRH is a key regulator of the VEGF signaling pathway and describe a mechanism whereby PRH plays an important role in tumorigenesis and leukemogenesis. PMID: 20176809
    38. the same genetic HHEX-IDE variant, which is associated with type 2 diabetes from previous studies, also influences pediatric body mass index PMID: 19933996
    39. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 20075150
    40. the interaction between Hhex and SOX13 may contribute to control Wnt/TCF1 signaling in the early embryo. PMID: 20028982
    41. there is an association between PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 and type 2 diabetes in the Chinese population PMID: 19862325
    42. HHEX has been implicated in pancreas development and the regulation of insulin secretion and risk of type 2 diabetes. PMID: 20080751
    43. genomic organization and chromosome 10 mapping PMID: 11701950
    44. PRH is a negative regulator of eIF4E in myeloid cells, interacting with eIF4E through a conserved binding site typically found in translational regulators PMID: 12554669
    45. HEX may not affect the differentiation of endothelial cells but acts as a negative regulator of angiogenesis. PMID: 12588764
    46. PRH interacts with the HC8 subunit of the proteasome in the context of both 20 and 26 S proteasomes and is associated with the proteasome in K562 hematopoietic cells; the proline-rich PRH N-terminal domain is responsible for this interaction. PMID: 12826010
    47. Hex can act as a T lineage oncogene when misexpressed in hematopoietic precursor cells PMID: 14555989
    48. Tgf-beta mediated repression of flk-1/KDR and mediated repression of flk-1/KDR and VEGF signaling involves the inducible formation of inhibitory Hex-GATA signaling Hex-GATA involves the formation of Hex-GATA complexes. PMID: 15016828
    49. Pax8 regulates the transcriptional activity of Hex promoter; several Pax8 binding sites in the Hex promoter are present PMID: 15062550
    50. Hex, a hematopoietically expressed homeobox protein, induces transcription of the SM22alpha gene by facilitating the interaction between SRF and its cognate binding site in embryonic fibroblasts. PMID: 15242862

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  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Liver and promyelocytic leukemia cell line HL-60.
  • 數據庫鏈接:

    HGNC: 4901

    OMIM: 604420

    KEGG: hsa:3087

    STRING: 9606.ENSP00000282728

    UniGene: Hs.118651



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