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  4. Recombinant Human Helicase POLQ-like (HELQ), partial

Recombinant Human Helicase POLQ-like (HELQ), partial

  • 中文名稱：
    人HELQ重組蛋白
  • 貨號：
    CSB-YP823463HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HELQ重組蛋白
  • 貨號：
    CSB-EP823463HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HELQ重組蛋白
  • 貨號：
    CSB-BP823463HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HELQ重組蛋白
  • 貨號：
    CSB-MP823463HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HELQ
  • Uniprot No.：
  • 別名：
    HEL308 protein; Helicase POLQ-like; Helicase, POLQ like; HELQ; HELQ_HUMAN; Mus308 like helicase; Mus308-like helicase; POLQ like helicase; POLQ-like helicase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links.
  • 基因功能參考文獻：
    1. HELQ plays an important role in regulating the expression of DNA repair proteins NER pathway which, in turn, contributes to cellular response to cisplatin and patients' response to platinum-based chemotherapy. PMID: 29572031
    2. WHD domain may contribute to ssDNA translocation, resulting in DNA helicase activity or in removal of other DNA bound proteins by "reeling" ssDNA. PMID: 28738244
    3. HELQ regulates the CHK1-RAD51 signaling pathway in osteosarcoma cells. PMID: 28000895
    4. Our results indicate that HELQ is not a major breast and ovarian cancer susceptibility gene in the Finnish population PMID: 26351136
    5. No mutation was identified. Our study indicates for the first time that mutations in the coding sequence of the HELQ gene may not be responsible for premature ovarian failure in Chinese Han population. PMID: 26190809
    6. Single nucleotide polymorphism in the HELQ gene is associated with upper aerodigestive tract cancers. PMID: 24658182
    7. HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR. PMID: 24005565
    8. one role for HEL308 at sites of blocked replication might be to open up the parental strands to facilitate the loading of subsequent factors required for replication restart. PMID: 21398521
    9. A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308 PMID: 11751861
    10. identification of homolog to POLN PMID: 12794064

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  • 蛋白家族：
    Helicase family, SKI2 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18536

    OMIM: 606769

    KEGG: hsa:113510

    STRING: 9606.ENSP00000295488

    UniGene: Hs.480101



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