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  4. Recombinant Human Hairy/enhancer-of-split related with YRPW motif-like protein (HEYL)

Recombinant Human Hairy/enhancer-of-split related with YRPW motif-like protein (HEYL)

  • 中文名稱：
    人HEYL重組蛋白
  • 貨號：
    CSB-YP865103HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HEYL重組蛋白
  • 貨號：
    CSB-EP865103HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HEYL重組蛋白
  • 貨號：
    CSB-EP865103HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HEYL重組蛋白
  • 貨號：
    CSB-BP865103HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HEYL重組蛋白
  • 貨號：
    CSB-MP865103HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HEYL
  • Uniprot No.：
  • 別名：
    bHLHb33; Class B basic helix loop helix protein 33; Class B basic helix-loop-helix protein 33; Hairy enhancer of split related with YRPW motif like; Hairy related transcription factor 3; Hairy-related transcription factor 3; Hairy/enhancer of split related with YRPW motif 3; Hairy/enhancer of split related with YRPW motif like; Hairy/enhancer of split related with YRPW motif like protein; Hairy/enhancer-of-split related with YRPW motif-like protein; HEY like protein; HEY3; heyl; HEYL protein; HEYL_HUMAN; hHeyL; hHRT3; HRT 3; HRT-3; HRT3; MGC12623
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-328
  • 氨基酸序列
    MKRPKEPSGS DGESDGPIDV GQEGQLSQMA RPLSTPSSSQ MQARKKHRGI IEKRRRDRIN SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA TGGTGFFDAR ALAVDFRSIG FRECLTEVIR YLGVLEGPSS RADPVRIRLL SHLNSYAAEM EPSPTPTGPL AFPAWPWSFF HSCPGLPALS NQLAILGRVP SPVLPGVSSP AYPIPALRTA PLRRATGIIL PARRNVLPSR GASSTRRARP LERPATPVPV APSSRAARSS HIAPLLQSSS PTPPGPTGSA AYVAVPTPNS SSPGPAGRPA GAMLYHSWVS EITEIGAF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
  • 基因功能參考文獻：
    1. HEYL rs784621 AA genotype is associated with poor response to therapy in Non-small Cell Lung Cancer. PMID: 28766235
    2. repression of TGFbeta signaling by Notch acting through HEYL may promote initiation of breast cancer PMID: 25217524
    3. Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors. PMID: 21454491
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    HEY family
  • 數據庫鏈接：

    HGNC: 4882

    OMIM: 609034

    KEGG: hsa:26508

    STRING: 9606.ENSP00000361943

    UniGene: Hs.472566



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