在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human HLA class II histocompatibility antigen, DQ beta 2 chain (HLA-DQB2), partial

  • 中文名稱:
    人HLA-DQB2重組蛋白
  • 貨號:
    CSB-YP356544HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人HLA-DQB2重組蛋白
  • 貨號:
    CSB-EP356544HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人HLA-DQB2重組蛋白
  • 貨號:
    CSB-EP356544HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人HLA-DQB2重組蛋白
  • 貨號:
    CSB-BP356544HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人HLA-DQB2重組蛋白
  • 貨號:
    CSB-MP356544HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    HLA-DQB2
  • Uniprot No.:
  • 別名:
    HLA-DQB2; HLA-DXBHLA class II histocompatibility antigen; DQ beta 2 chain; HLA class II histocompatibility antigen; DX beta chain; MHC class II antigen DQB2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
  • 基因功能參考文獻:
    1. No statistically significant association was found between rs7453920 SNP and chronic hepatitis B. PMID: 28613373
    2. this study shows that HLA-DQ gene polymorphisms are associated with ankylosing spondylitis in Southwest China PMID: 27394003
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
  • 蛋白家族:
    MHC class II family
  • 組織特異性:
    Restricted to skin Langerhans cells (at protein level).
  • 數據庫鏈接:

    HGNC: 4945

    OMIM: 615161

    KEGG: hsa:3120

    UniGene: Hs.731563



主站蜘蛛池模板: 最新精品国偷自产在线美女足| 国产精品亚洲а∨无码播放| 伊人婷婷色香五月综合缴缴情| av无码av在线a∨天堂毛片| 开心婷婷五月激情综合社区| 精品国产乱码久久久久久影片| 欧美日韩不卡视频合集| 激情综合婷婷丁香五月情 | 久久久久人妻一区精品| 国产男女猛烈无遮挡免费网站| 久久久久爽爽爽爽一区老女人| 无码8090精品久久一区| 无码毛片一区二区本码视频| 亚洲 小说区 图片区 都市| 麻豆av传媒蜜桃天美传媒| 久久综合狠狠综合久久综| 色哟哟精品视频在线观看| 国产suv精品一区| 最新高清中文字幕免费mv| 亚洲桃色天堂网| 亚洲成av人的天堂在线观看| 国产精品交换| 国产亚洲一卡2卡3卡4卡网站| 一边吃奶一边添p好爽高清视频| 国产伦理一区二区| 在线天堂新版最新版在线8| 国产成人毛片无码视频软件| 国产成人无码午夜视频在线观看| 中国国语毛片免费观看视频| 色一情一乱一伦一区二区三区小说 | 国产精品18禁污污网站| 成人性生交大片免费看视频app| 亚洲精品久久久久久久蜜臀老牛 | av人摸人人人澡人人超碰手机版| 人妻丰满熟妇岳av无码区hd| 国产免费一区二区三区免费视频| 日韩av第一页在线播放| 老师粉嫩小泬喷水视频90| 亚洲国产日韩精品一区二区三区| 先锋人妻无码av电影| 国产成人无码短视频|