在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Guanine nucleotide-binding protein subunit beta-5 (GNB5)

  • 中文名稱:
    人GNB5重組蛋白
  • 貨號:
    CSB-YP009608HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GNB5重組蛋白
  • 貨號:
    CSB-EP009608HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GNB5重組蛋白
  • 貨號:
    CSB-BP009608HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GNB5重組蛋白
  • 貨號:
    CSB-MP009608HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    FLJ37457; FLJ43714; G protein beta 5 subunit; G protein beta subunit 5L; GB 5; GB5; GBB5_HUMAN; Gbeta5; GNB 5; GNB5; Guanine nucleotide binding protein (G protein) beta 5; Guanine nucleotide binding protein beta 5; Guanine nucleotide binding protein beta 5 subunit; Guanine nucleotide binding protein beta subunit 5L; Guanine nucleotide binding protein subunit beta 5; Guanine nucleotide-binding protein subunit beta-5; Transducin beta chain 5
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Isoform 2
  • 表達區域:
    1-353aa
  • 氨基酸序列
    MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate.
  • 基因功能參考文獻:
    1. individuals with loss-of-function GNB5 alleles had more severe symptoms, including substantial developmental delay, speech defects, severe hypotonia, pathological gastro-esophageal reflux, retinal disease, and sinus-node dysfunction, whereas related heterozygotes harboring missense variants presented with a clinically milder phenotype PMID: 27523599
    2. Results suggest that D2R can interact with and stabilize the Gb5 protein, independently of R7 G protein signaling (RGS) proteins. PMID: 25162404
    3. The intrinsic resistance to TRAIL-triggered apoptosis of colon cancer cells is overcome by antagonization of Gbeta5. PMID: 25043307
    4. Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors PMID: 21511947
    5. Gbeta5's function in vision is reviewed. PMID: 20374718
    6. under certain conditions, RGS9 and Gbeta5 may possibly function as betagamma dimer PMID: 15474482
    7. From yeast two hybrid screening with HBX as bait, human guanine nucleotide binding protein beta subunit 5L (GNbeta5) was isolated from the cDNA library constructed in this study as a new hepatitis b X protein-interacting protein. PMID: 16135253
    8. cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP. PMID: 16867977
    9. G-protein beta5 short splice variant isoform is indispensable for outer plexiform layer integrity and normal light responses of the retina in transgenic mice. PMID: 18094259
    10. cytosolic chaperonin complex-dependent mechanism exists for Gbeta5-RGS7 assembly that utilizes the co-chaperone activity of PhLP1 in a unique way. PMID: 19376773

    顯示更多

    收起更多

  • 相關疾病:
    Intellectual developmental disorder with cardiac arrhythmia (IDDCA); Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia (LADCI)
  • 亞細胞定位:
    Membrane.
  • 蛋白家族:
    WD repeat G protein beta family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 4401

    OMIM: 604447

    KEGG: hsa:10681

    STRING: 9606.ENSP00000261837

    UniGene: Hs.155090



主站蜘蛛池模板: 四虎亚洲欧美成人网站| 吃奶呻吟打开双腿做受动态图| 天天做天天爱夜夜爽| 亚洲综合小说另类图片五月天| 日韩免费人妻av无码专区蜜桃| 亚洲欧美日韩一区在线观看| 国产午夜精品av一区二区麻豆| 凹凸国产熟女精品视频app| 国产拍拍拍无码视频免费| 久久国产色欲av38| 露脸内射熟女--69xx| 在线播放无码高潮的视频| 在线亚洲欧美日韩精品专区| 岛国av无码免费无禁网站麦芽 | 多人伦交性欧美| 午夜成人鲁丝片午夜精品| 影音先锋在线资源无码| 色欲久久综合亚洲精品蜜桃| 亚洲综合另类小说专区| 精品国精品国产自在久国产应用| 色欲久久久天天天综合网| 国产制服丝袜亚洲高清| 亚洲第一a在线观看网站| 丰满人妻一区二区三区免费视频| av淘宝国产在线观看| 99久久无色码中文字幕人妻| 萝卜视频高清免费视频日本| 在线亚洲人成电影网站色www| 国产-第1页-浮力影院| 久久99国产综合精品女同| 一本一久本久a久久精品综合| 国产精品无码制服丝袜| 久久久亚洲精品无码| 中文字幕一区二区精品区| 人与嘼av免费| 国产色无码精品视频国产| 最新网站亚洲人成无码| 日韩v亚洲v欧美v精品综合| 国产成人久久av免费高潮| 中国精品偷拍区偷拍无码| 扒开双腿猛进入喷水高潮视频 |