在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Golgi to ER traffic protein 4 homolog (GET4)

Recombinant Human Golgi to ER traffic protein 4 homolog (GET4)

  • 中文名稱：
    人GET4重組蛋白
  • 貨號：
    CSB-YP752100HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GET4重組蛋白
  • 貨號：
    CSB-EP752100HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GET4重組蛋白
  • 貨號：
    CSB-EP752100HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GET4重組蛋白
  • 貨號：
    CSB-BP752100HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GET4重組蛋白
  • 貨號：
    CSB-MP752100HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GET4
  • Uniprot No.：
  • 別名：
    C7orf20; CGI 20; CGI20; Conserved edge expressed protein; Conserved edge protein; Conserved edge-expressed protein; GET 4; GET4; GET4_HUMAN; Golgi to ER traffic protein 4 homolog (S. cerevisiae); Golgi to ER traffic protein 4 homolog; Transmembrane domain recognition complex 35 kDa subunit; Transmembrane domain recognition complex 35kDa; TRC35; UPF0363 protein C7orf20
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    2-327
  • 氨基酸序列
    AAAAAMAEQ ESARNGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQSKHT EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVEV ADELLENLAK VFSLMDPNSP ERVTFVSRAL KWSSGGSGKL GHPRLHQLLA LTLWKEQNYC ESRYHFLHSA DGEGCANMLV EYSTSRGFRS EVDMFVAQAV LQFLCLKNKS SASVVFTTYT QKHPSIEDGP PFVEPLLNFI WFLLLAVDGG KLTVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN LLTSLMGSSE QEDGEESPSD GSPIELD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
  • 基因功能參考文獻：
    1. Both TRC35 and Ubl4A have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex. PMID: 25535373
    2. The crystal structure of the Get3-Get4-Get5 complex in an ATP-bound state is presented. PMID: 24727835
    3. Data indicate that BCL2-associated athanogene 6 (BAG6) appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A and GET4 proteins and resistance to cell killing by DNA-damaging agents. PMID: 23723067
    4. Data indicate that the Bag6-Ubl4A-Trc35 complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD). PMID: 23665563
    5. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. PMID: 23246001

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    GET4 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21690

    OMIM: 612056

    KEGG: hsa:51608

    STRING: 9606.ENSP00000265857

    UniGene: Hs.107387



主站蜘蛛池模板： 萝卜视频高清免费视频日本| 日本阿v网站在线观看中文| 亚洲爆乳无码精品aaa片蜜桃| 五月天激情电影| 欧洲亚洲1卡二卡三卡2021| 亚洲欧洲久久av| a在线视频v视频| 一本一道波多野结衣av黑人| 和岳每晚弄的高潮嗷嗷叫视频| 99re6热精品视频在线观看| 亚洲欧洲无码av不卡在线| 色哟哟最新在线观看入口| 欧美浓毛大泬视频| 久久综合狠狠色综合伊人| 免费裸体黄网站18禁免费| 狠狠色狠狠色狠狠五月| 男女无遮挡xx00动态图120秒| 成人欧美一区二区三区黑人 | 777米奇影院狠狠色| 成人乱码一区二区三区av| 久久国产色av免费看| 国产清纯白嫩初高生在线观看| 久久婷婷综合缴情亚洲狠狠_| 婷婷综合缴情亚洲| 99久久久无码国产精品不卡 | 亚洲国产高清在线一区二区三区| 亚洲欧美v国产一区二区| 中文无码日韩欧免费视频| 亚洲www啪成人一区二区麻豆| 天堂网www中文在线 | 无码人妻丰满熟妇啪啪7774| 欧美成人精品三级网站视频| 亚洲精品久久久久国产| 中文字幕乱码人妻二区三区| 越猛烈欧美xx00动态图| 国产性色av一区二区三区| 精品人人妻人人澡人人爽牛牛| 久久久久亚洲精品男人的天堂| 国产在线精品无码不卡手机免费| 青青草无码精品伊人久久| 日本va欧美va欧美va精品|