在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Glucosidase 2 subunit beta (PRKCSH)

Recombinant Human Glucosidase 2 subunit beta (PRKCSH)

  • 中文名稱：
    人PRKCSH重組蛋白
  • 貨號：
    CSB-YP018709HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PRKCSH重組蛋白
  • 貨號：
    CSB-EP018709HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PRKCSH重組蛋白
  • 貨號：
    CSB-EP018709HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PRKCSH重組蛋白
  • 貨號：
    CSB-BP018709HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PRKCSH重組蛋白
  • 貨號：
    CSB-MP018709HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    80K-H protein; AGE-binding receptor 2; AGE-R2; G19P1; GLU2B_HUMAN; Glucosidase 2 subunit beta; Glucosidase II beta subunit; Glucosidase II subunit beta; Hepatocystin; PCLD; PKCSH; PLD1; PRKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain; Protein kinase C substrate 80 Kda protein; Protein kinase C substrate 80K-H; Protein kinase C substrate; 80 Kda protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    15-528
  • 氨基酸序列
    VEVKRP RGVSLTNHHF YDESKPFTCL DGSATIPFDQ VNDDYCDCKD GSDEPGTAAC PNGSFHCTNT GYKPLYIPSN RVNDGVCDCC DGTDEYNSGV ICENTCKEKG RKERESLQQM AEVTREGFRL KKILIEDWKK AREEKQKKLI ELQAGKKSLE DQVEMLRTVK EEAEKPEREA KEQHQKLWEE QLAAAKAQQE QELAADAFKE LDDDMDGTVS VTELQTHPEL DTDGDGALSE AEAQALLSGD TQTDATSFYD RVWAAIRDKY RSEALPTDLP APSAPDLTEP KEEQPPVPSS PTEEEEEEEE EEEEEAEEEE EEEDSEEAPP PLSPPQPASP AEEDKMPPYD EQTQAFIDAA QEARNKFEEA ERSLKDMEES IRNLEQEISF DFGPNGEFAY LYSQCYELTT NEYVYRLCPF KLVSQKPKLG GSPTSLGTWG SWIGPDHDKF SAMKYEQGTG CWQGPNRSTT VRLLCGKETM VTSTTEPSRC EYLMELMTPA ACPEPPPEAP TEDDHDEL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia.
  • 基因功能參考文獻：
    1. Results suggest that loss of PRKCSH and SEC63 leads to general defects in ciliogenesis, while quenching of the Wnt signaling cascade is cholangiocyte-restricted. PMID: 28973524
    2. This study demonstrated that Large copy number variations on germline level are not present in patients with a clinical diagnosis of Severe Polycystic Liver Disease. PMID: 26365003
    3. Polycystic liver disease is recessive at the cellular level, and loss of functional PRKCSH is an important step in cystogenesis. PMID: 21856269
    4. The induction of autophagy by hepatocystin deficiency is mediated through mammalian target of rapamycin (mTOR). PMID: 21681021
    5. Results provide evidence that mutations at the coding PRKCSH GAG repeat are a target of MSI and are selectively associated with the MSI-H phenotype in gastric carcinomas. PMID: 21371016
    6. The common SNPs tested in DDOST, PRKCSH and LGALS3 do not seem to be associated with diabetic micro- or macrovascular complications or with type 1 diabetes in Finnish patients. PMID: 20490454
    7. identified a total of 26 novel mutations in PRKCSH (n = 14) and SEC63 (n = 12), including four splice site mutations, eight insertions/ deletions, six non-sense mutations, and eight missense mutations PMID: 20095989
    8. Our results suggest that PRKCSH gene is not a major genetic cause of PCLD and there may be at least another locus responsible for the disease in Taiwan. PMID: 19308730
    9. PRKCSH functions as a chaperone-like molecule, which prevents endoplasmic reticulum-associated degradation of TRPP2. PMID: 19801576
    10. Mutations in this protein cause isolated autosomal dominant polycystic liver disease. PMID: 12529853
    11. germline mutations in PRKCSH as the probable cause of autosomal dominant polycystic liver disease PMID: 12577059
    12. autosomal dominant polycystic liver disease is genetically heterogeneous PMID: 15057895
    13. role of hepatocystin in carbohydrate processing and quality control of newly synthesized glycoproteins in the endoplasmic reticulum PMID: 15188177
    14. results identify 80K-H as a new player involved in GLUT4 vesicle transport and identify a link between a kinase involved in the insulin signalling cascade, PKCzeta, and a known component of the GLUT4 vesicle trafficking pathway, munc18c PMID: 15707389
    15. the majority of cysts from PRKCSH mutation carriers did not express hepatocystin PMID: 18224332
    16. Hepatocystin is not secreted in liver cyst fluids of autosomal dominant polycystic liver disease patients, suggesting that mutant hepatocystin is either not produced or degraded intracellularly. PMID: 18419150
    17. 80K-H is a novel regulator of IP3R1 activity, and it may contribute to neuronal functions. PMID: 18990696
    18. These results indicate that insulin induces dynamic associations between PKCzeta, 80K-H, and munc18c and that 80K-H may act as a key signaling link between PKCzeta and munc18c in live cells. PMID: 19061073

    顯示更多

    收起更多

  • 相關疾病：
    Polycystic liver disease 1 (PCLD1)
  • 亞細胞定位：
    Endoplasmic reticulum.
  • 數據庫鏈接：

    HGNC: 9411

    OMIM: 174050

    KEGG: hsa:5589

    STRING: 9606.ENSP00000252455

    UniGene: Hs.610830



主站蜘蛛池模板： 人妻少妇伦在线麻豆m电影| 97色偷偷色噜噜狠狠爱网站97| 免费观看潮喷到高潮中文字幕| 亚洲熟妇av一区二区三区浪潮| 国产精品久久久久久熟妇吹潮软件| 国产专区国产av| 少妇极品熟妇人妻| 在线中文新版最新版在线 | 日韩高清在线亚洲专区小说| 亚洲人亚洲人成电影网站色| 国产9色在线 | 日韩| 国内精品久久久久影院薰衣草 | 国产偷国产偷亚洲清高| 亚洲中文欧美在线视频| 国产精品久久自在自线不| 激情五月婷婷| 真人性生交免费视频| 欧美日韩人成视频在线播放| 国产白嫩护士被弄高潮| 亚洲大尺度无码无码专线一区| 五月丁香六月激情综合在线视频| 日产欧美国产日韩精品| 小嫩妇好紧好爽18禁视频| www污污污抽搐喷潮com| 97se亚洲国产综合自在线尤物| 18禁无遮挡羞羞污污污污网站| 狠狠躁夜夜躁人人躁婷婷视频| 亚洲乱码精品久久久久..| 日本中文字幕一区二区有码在线 | 亚洲无碼网站观看| 欧美丰满熟妇xxxx性大屁股| 中文在线中文a| 日99久9在线 | 免费| 国产日产韩国精品视频| 少妇人妻综合久久中文字幕| 女人高潮抽搐潮喷小视频| 高清免费精品国自产拍| 亚洲综合一区二区三区无码| 失禁潮痉挛潮喷av在线无码| 无码人妻丝袜在线视频红杏| 成人区人妻精品一区二区不卡网站|