在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Gastrotropin (FABP6)

  • 中文名稱:
    人FABP6重組蛋白
  • 貨號:
    CSB-EP007955HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Fabp6; FABP6_HUMAN; Fatty acid binding protein 6; ileal (gastrotropin) ; Fatty acid-binding protein 6; Gastrotropin; GT; I 15P; I BABP ; I BALB; I BAP; I-15P; I-BABP; I15P; IBABP ; IBALB; IBAP; ILBP; ILBP3 ; Ileal lipid binding protein; Ileal lipid-binding protein; ILLBP ; Intestinal 15 kDa protein; Intestinal bile acid binding protein; Intestinal bile acid-binding protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of BC022489
  • 來源:
    E.coli
  • 分子量:
    41.4kDa
  • 表達區域:
    1-128aa
  • 氨基酸序列
    MAFTGKFEMESEKNYDEFMKLLGISSDVIEKAHNFKIVTEVQQDGQDFTWSQHYYGGHTMTNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTSEIVGDKLVEVSTIGGVTYERVSKRLA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion.; Essential for the survival of colon cancer cells to bile acid-induced apoptosis.
  • 基因功能參考文獻:
    1. Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR PMID: 26613247
    2. Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments. PMID: 25073073
    3. show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations PMID: 23758264
    4. Ursodeoxycholic acid induces unique conformational changes in IBABP. PMID: 22223860
    5. NMR data are in agreement with a conformational selection model we proposed earlier for I-BABP and support the hypothesis of an allosteric mechanism of ligand binding PMID: 22329738
    6. The-putative functional-Thr79Met substitution of FABP6 confers a protective effect on type 2 diabetes in obese individuals. PMID: 19744871
    7. NMR structure of human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures PMID: 12486725
    8. the I-BABP gene may be a novel target for PPAR in humans PMID: 15936983
    9. ASBT and ILBP protein were 48% and 67% lower in normal weight gallstone carriers than in controls (P < 0.05); similar differences were found for mRNA expression levels. PMID: 16237211
    10. The expression of FABP6 was higher in primary colorectal cancers and adenomas than in normal epithelium, but was dramatically decreased in lymph node metastases, suggesting that FABP6 may play an important role in early carcinogenesis. PMID: 16951225
    11. In keeping with its role in the enterohepatic circulation and ileal reabsorption of bile acids, the gene promoter contains consensus elements for CDX2 and FXR. More than one transcription start site has been identified. PMID: 14654244

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 組織特異性:
    Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in c
  • 數據庫鏈接:

    HGNC: 3561

    OMIM: 600422

    KEGG: hsa:2172

    STRING: 9606.ENSP00000377549

    UniGene: Hs.519719



主站蜘蛛池模板: av片在线播放| 啪啪激情婷婷久久婷婷色五月| 国产农村乱辈无码| 久久久久免费看黄a片app| 国内精品久久久久久中文字幕| 国产边摸边吃奶边做爽视频| 亚洲一线产区二线产区分布| 精品一区二区三区自拍图片区| 国产精品自产拍在线观看| 久久久亚洲欧洲日产国码606| 国产精品久久久久久久久岛| 午夜视频在线在免费| 久久久久久夜精品精品免费啦| 色狠狠av老熟女| 熟女俱乐部五十路六十路av| 男女下面一进一出好爽视频| 久久久免费无码成人影片| 国产熟女一区二区三区四区五区| 成人无码www在线看免费| 欧美日韩人成视频在线播放| 欧洲熟妇色xxxx欧美老妇软件| 亚洲已满18点击进入在线看片| 国产av亚洲精品久久久久久 | 天天操夜夜操| 欧美成人一卡二卡三卡四卡| 欧美毛多水多肥妇| 久久亚洲a片com人成| 人妻人人澡人人添人人爽人人玩| 亚洲一区二区三区在线网址| 鲁大师在线视频播放免费观看| 久久综合九色综合欧美狠狠| 他用舌头给我高潮喷水在线| 国产日韩在线视看第一页| 日本免费视频| 日本亚洲欧美在线视观看| 天堂中文在线最新版地址| 熟妇人妻系列av无码一区二区| 狂野欧美性猛xxxx乱大交| 欧美乱妇xxxxxbbbbb| 精品无码av一区二区三区不卡| 人妻中文字幕乱人伦在线|