在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5), partial

  • 中文名稱:
    人GABRA5重組蛋白
  • 貨號:
    CSB-YP009144HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GABRA5重組蛋白
  • 貨號:
    CSB-EP009144HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人GABRA5重組蛋白
  • 貨號:
    CSB-EP009144HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GABRA5重組蛋白
  • 貨號:
    CSB-BP009144HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GABRA5重組蛋白
  • 貨號:
    CSB-MP009144HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    GABRA5
  • Uniprot No.:
  • 別名:
    GAA 5; GAA5; GABA(A) receptor subunit alpha-5; GABRA 5; Gabra5; Gamma aminobutyric acid GABA A receptor alpha 5; Gamma aminobutyric acid GABA A receptor alpha 5 precursor; Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor; Gamma-aminobutyric acid receptor subunit alpha-5; GBRA5_HUMAN; GC138184
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse.
  • 基因功能參考文獻:
    1. Low GABRA5 expression typified hyperproliferative tumors, and loss of taurine signaling correlated with reduced patient survival, suggesting this tumor suppressive mechanism operates in vivo. PMID: 29787571
    2. Study found a significant reduction in [(11)C]Ro15 4513 binding in the nucleus accumbens in an opiate-dependent compared with the healthy control group. Study suggests that reduced GABA A receptor alpha5 levels in the nucleus accumbens are associated with addiction. PMID: 26876472
    3. Report benzodiazepine derivative as GABA-site inhibitor of extra-synaptic GABAA alpha5 receptors. PMID: 26169564
    4. Study found that a significant portion of GABAergic postsynaptic compartments contain the alpha5 GABAAR subunit, both in vitro and in vivo PMID: 25663431
    5. This study showed that in male groups, the expression of GABRA5 was generally lower in schizophrenia cases compared to the control. PMID: 25660468
    6. Findings provide genetic evidence for the involvement of the genes GABRB3 and GABRA5 in the susceptibility to panic disorder PMID: 24755890
    7. 1,2-dichlorohexafluorocyclobutane enhancement of GABRA5 activity is abolished by GABRB3 mutations. PMID: 25211390
    8. The alpha5 nicotinic receptor GABAergic neurons form a link from the medial habenula to the serotonergic brain centers. PMID: 24227714
    9. These results provide initial evidence of a GABAA alpha5 deficit in autism spectrum disorder and support further investigations of the GABA system in this disorder. PMID: 22546616
    10. In subjects with schizophrenia, mean GABA (A) alpha5 rerceptor subunit mRNA expression is 15% lower in layer 4 of the dorsolateral prefrontal cortex. PMID: 20843900
    11. These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder. PMID: 15882799
    12. GABA(A) receptor alpha5 subunit as a candidate gene for autism and bipolar disorder; observations suggest parent-of-origin and gain-of-function effects PMID: 17353214

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA5 sub-subfamily
  • 數據庫鏈接:

    HGNC: 4079

    OMIM: 137142

    KEGG: hsa:2558

    STRING: 9606.ENSP00000335592

    UniGene: Hs.24969



主站蜘蛛池模板: 丰满大肥婆肥奶大屁股| 国产亚洲熟妇综合视频| 中文字幕日产乱码国内自| 国产精品无码无卡在线播放| 99国产精品国产精品九九| 国产国语毛片在线看国产| 性国产牲交xxxxx视频| 亚洲乱码伦小说区| 正在播放老肥熟妇露脸| 中文字幕人妻少妇引诱隔壁| 四库影院永久国产精品地址| 国产99视频精品免视看7| 欧美刺激性大交| 熟女人妻av粗壮巨龙| 99这里有精品视频视频| 人妻中出受孕 中文字幕在线| 女人爽得直叫免费视频| 一本久道久久综合狠狠老| 人人超碰人人超级碰国| 亚洲性啪啪无码av天堂| 婷婷成人丁香五月综合激情| 亚洲熟妇av一区二区三区宅男| 日本高清视频wwww色| 成人欧美一区二区三区黑人| 国产成人亚洲综合网色欲网| 2018av无码视频在线播放| 日韩激情无码不卡码| 国产亚洲情侣一区二区无| 熟女俱乐部五十路六十路| 亚洲日本成本人观看| 国产精品永久免费| 欧美日韩国产亚洲沙发| 日韩精品成人av在线观看| 韩国精品一区二区无码视频| 伊在人天堂亚洲香蕉精品区| 国产美女精品中文网蜜芽宝贝| 加勒比无码一区二区三区| 无码精品国产dvd在线观看9久| 午夜成人亚洲理论片在线观看| 女人高潮抽搐喷液30分钟视频| 肉大榛一进一出免费视频|