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GABRA5 Recombinant Monoclonal Antibody

  • 中文名稱：
    GABRA5重組抗體
  • 貨號：
    CSB-RA559038A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Ntera-2 whole cell lysate, HEK293 whole cell lysate
      All lanes: GABA A Receptor alpha 5 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 53 kDa
      Observed band size: 70 kDa
    • IHC image of CSB-RA559038A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    GABRA5 Recombinant Monoclonal Antibody（CSB-RA559038A0HU）是針對γ-氨基丁酸A型受體α5亞基（GABRA5）的高特異性科研工具。GABRA5是中樞神經(jīng)系統(tǒng)GABA-A受體的重要組成亞基，主要分布于海馬和大腦皮層，通過介導(dǎo)抑制性神經(jīng)遞質(zhì)GABA的氯離子通道功能參與突觸可塑性調(diào)節(jié)，與認知功能及神經(jīng)精神疾病密切相關(guān)。該抗體經(jīng)ELISA、Western Blot（WB）和免疫組化（IHC）多平臺驗證，在WB實驗中可精準識別天然蛋白，推薦使用稀釋度為1:500-1:5000；在IHC應(yīng)用中能清晰顯示石蠟包埋組織樣本中靶蛋白的亞細胞定位，推薦稀釋度1:50-1:200。其重組單克隆特性保證了批次間的高度一致性，適用于神經(jīng)遞質(zhì)受體表達調(diào)控研究、腦區(qū)特異性功能解析以及神經(jīng)退行性疾病模型的分子機制探索。本產(chǎn)品為神經(jīng)系統(tǒng)基礎(chǔ)研究提供可靠工具，可用于蛋白互作分析、受體分布圖譜構(gòu)建及相關(guān)信號通路的功能研究，嚴格限于科研領(lǐng)域使用。
  • Uniprot No.：
  • 基因名：
    GABRA5
  • 別名：
    Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5), GABRA5
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human GABA A Receptor alpha 5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    5C11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse.
  • 基因功能參考文獻：
    1. Low GABRA5 expression typified hyperproliferative tumors, and loss of taurine signaling correlated with reduced patient survival, suggesting this tumor suppressive mechanism operates in vivo. PMID: 29787571
    2. Study found a significant reduction in [(11)C]Ro15 4513 binding in the nucleus accumbens in an opiate-dependent compared with the healthy control group. Study suggests that reduced GABA A receptor alpha5 levels in the nucleus accumbens are associated with addiction. PMID: 26876472
    3. Report benzodiazepine derivative as GABA-site inhibitor of extra-synaptic GABAA alpha5 receptors. PMID: 26169564
    4. Study found that a significant portion of GABAergic postsynaptic compartments contain the alpha5 GABAAR subunit, both in vitro and in vivo PMID: 25663431
    5. This study showed that in male groups, the expression of GABRA5 was generally lower in schizophrenia cases compared to the control. PMID: 25660468
    6. Findings provide genetic evidence for the involvement of the genes GABRB3 and GABRA5 in the susceptibility to panic disorder PMID: 24755890
    7. 1,2-dichlorohexafluorocyclobutane enhancement of GABRA5 activity is abolished by GABRB3 mutations. PMID: 25211390
    8. The alpha5 nicotinic receptor GABAergic neurons form a link from the medial habenula to the serotonergic brain centers. PMID: 24227714
    9. These results provide initial evidence of a GABAA alpha5 deficit in autism spectrum disorder and support further investigations of the GABA system in this disorder. PMID: 22546616
    10. In subjects with schizophrenia, mean GABA (A) alpha5 rerceptor subunit mRNA expression is 15% lower in layer 4 of the dorsolateral prefrontal cortex. PMID: 20843900
    11. These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder. PMID: 15882799
    12. GABA(A) receptor alpha5 subunit as a candidate gene for autism and bipolar disorder; observations suggest parent-of-origin and gain-of-function effects PMID: 17353214

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  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA5 sub-subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4079

    OMIM: 137142

    KEGG: hsa:2558

    STRING: 9606.ENSP00000335592

    UniGene: Hs.24969



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