在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human GTP cyclohydrolase 1 feedback regulatory protein (GCHFR)

  • 中文名稱:
    人GCHFR重組蛋白
  • 貨號:
    CSB-YP009318HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GCHFR重組蛋白
  • 貨號:
    CSB-EP009318HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人GCHFR重組蛋白
  • 貨號:
    CSB-EP009318HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GCHFR重組蛋白
  • 貨號:
    CSB-BP009318HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GCHFR重組蛋白
  • 貨號:
    CSB-MP009318HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    GCHFR
  • Uniprot No.:
  • 別名:
    GCHFR; GFRP; GFRP_HUMAN; GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulator; GTP cyclohydrolase I feedback regulatory protein; HsT16933; MGC138467; MGC138469; p35
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-84
  • 氨基酸序列
    PYLLISTQI RMEVGPTMVG DEQSDPELMQ HLGASKRRAL GNNFYEYYVD DPPRIVLDKL ERRGFRVLSM TGVGQTLVWC LHKE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
  • 基因功能參考文獻:
    1. homozygous individuals for the TT haplotype were less likely to respond to the SSRI fluoxetine than to the nortriptyline suggesting a biological process through which GCHFR promoter variants might influence antidepressant response. PMID: 20351752
    2. Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein PMID: 11799107
    3. allosteric regulation of GTPCH-I activity in the cardiovascular system maybe an important mechanism regulating BH4 levels through GTPCH-I feedback regulatory protein signaling PMID: 15649650
    4. GFRP/GTPCHI axis functions in epidermal keratinocytes and melanocytes in the cytosol and nucleus. PMID: 16778797
    5. GCH1 mutations in Japanese patients with DYT5 dystonia. In some of them, the GCH1 enzyme activity was proved to be impaired. PMID: 17101830
    6. The co-expression of GTP cyclohydrolase I (GCHI) with tyrosine hydroxylase (TH) indicates that TH is indeed active in human neurosecretory neurons. PMID: 17135716
    7. Demonstrate role for GFRP in regulating iNOS-mediated NO synthesis and suggest that the allosteric regulation of GTP-CH1 activity by GFRP may be an important mechanism regulating BH(4) and NO levels in vivo. PMID: 18372436
    8. crystal structure PMID: 11580249

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus membrane. Cytoplasm, cytosol.
  • 蛋白家族:
    GFRP family
  • 組織特異性:
    In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
  • 數據庫鏈接:

    HGNC: 4194

    OMIM: 602437

    KEGG: hsa:2644

    STRING: 9606.ENSP00000260447

    UniGene: Hs.631717



主站蜘蛛池模板: 特级做a爰片毛片免费69| 美女裸体十八禁免费网站| 色资源av中文无码先锋| 国产精品亚洲精品日韩已满十八小| 夜夜爽狠狠天天婷婷五月| 国产99久9在线视频 | 传媒| 女人高潮抽搐潮喷视频开腿| 9lporm自拍视频区| 熟妇无码乱子成人精品| 亚洲午夜国产精品无码老牛影视| 免费人妻精品一区二区三区| 婷婷丁香六月激情综合在线人 | av色国产色拍| 精品国际久久久久999波多野| 亚洲欧美日韩一区在线观看| 久久久久波多野结衣高潮| 成年女人色毛片| 亚洲高清有码中文字| 最新69成人精品视频免费| 人妻无码中文专区久久五月婷| 中文字幕无码乱码人妻系列蜜桃| 欧妇女乱妇女乱视频| 欧洲免费无线码在线一区| 午夜爱爱免费视频体验区| 亚洲成av人片在线观l看福利1| 亚洲欭美日韩颜射在线二| 18禁美女黄网站色大片免费看| 新版天堂资源中文www连接| 无码综合天天久久综合网色吧影院| 狠狠色狠狠色综合日日五| 开心久久婷婷综合中文字幕| 亚欧无线一线二线三线区别| 欧美亚洲人成网站在线观看| 国产真实乱对白精彩久久| 曰本无码人妻丰满熟妇啪啪| 一色屋精品视频在线观看| 青草精品国产福利在线视频| 偷拍农村老熟妇xxxxx7视频| 一二三四在线视频观看社区| 九月婷婷人人澡人人添人人爽| 亚洲欧美综合一区二区三区|