在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human G-protein coupled receptor 39 (GPR39), partial

Recombinant Human G-protein coupled receptor 39 (GPR39), partial

  • 中文名稱：
    人GPR39重組蛋白
  • 貨號：
    CSB-YP009812HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GPR39重組蛋白
  • 貨號：
    CSB-EP009812HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GPR39重組蛋白
  • 貨號：
    CSB-EP009812HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GPR39重組蛋白
  • 貨號：
    CSB-BP009812HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GPR39重組蛋白
  • 貨號：
    CSB-MP009812HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    GPR39; G-protein coupled receptor 39
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death.
  • 基因功能參考文獻：
    1. data indicate that Zn(2+) acting via ZnR/GPR39 has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets. PMID: 28093242
    2. G protein-coupled receptor 39 (ZnR/GPR39) was shown to regulate the activity of ion transport mechanisms that are essential for the physiological function of epithelial and neuronal cells [Review]. PMID: 29389900
    3. Data suggest that expression of GPR39 undergoes Rho kinase-dependent desensitization following activation by zinc. PMID: 28619258
    4. This study demonstrated that zinc upregulates PKCzeta by activating GPR39 to enhance the abundance of ZO-1, thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells. PMID: 28515165
    5. obestatin/GPR39 system in the pathogenesis and/or clinical outcome of human gastric adenocarcinomas and highlight the potential usefulness of GPR39 as a prognostic marker in gastric cancer. PMID: 26716511
    6. Chronic administration of many antidepressants induces GPR39 up-regulation, which suggests that the Zn(2+)-sensing receptor may be considered as a new target for drug development in the field of depression. PMID: 25490458
    7. Taken together, our results provided a novel regulatory mechanism for GPR39-1b in NTRS1 signaling. PMID: 24512471
    8. ZnR/GPR39-dependent expression of tight junctional proteins, thereby leading to formation of a sealed intestinal epithelial barrier. PMID: 24967969
    9. Data suggests alterations (down-regulation) of the GPR39 receptor and involvement of CREB-BDNF pathway, possibly triggered by GPR39, as a new pathomechanism of depression PMID: 24333148
    10. Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein S100A4 that is linked to invasion of prostate cancer cells. PMID: 24264723
    11. GPR39 was present in thyroid autoimmune disease, non-toxic nodular goiter and toxic nodular goiter at band p51(kDa). PMID: 23485550
    12. ZnR/GPR39 is tuned to sense physiologically relevant changes in extracellular pH that regulate ZnR-dependent signaling and ion transport activity PMID: 22879599
    13. GPR39 activation increased the expression of the anti-apoptotic protein clusterin in butyrate-treated cells. GPR39 mediates Zn2+-dependent cell growth. PMID: 22545109
    14. GPR39 plays an important tumorigenic role in the development and progression of esophageal squamous cell carcinoma. PMID: 21352519
    15. extracellular Zn(2+), either applied or released following injury, activates ZnR/GPR39 to promote signaling leading to epithelial repair PMID: 20522546
    16. Data show that Phe-V:13 can serve as an aromatic lock for the proposed active conformation of the Trp-VI:13 rotameric switch, being involved in the global movement of TM-V and TM-VI in 7TM receptor activation. PMID: 19920139
    17. GPR39 is probably not the obestatin receptor PMID: 16959833
    18. could activate GPR39 by high concentrations of Zn(2+), demonstrating cell surface expression of a functional receptor that could elicit a Ca(2+) response. PMID: 17054911
    19. GPR39 functions as a Gq-coupled Zn2+-sensing receptor PMID: 17885920
    20. GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor PMID: 18180304
    21. It is proposed that Zn2+ acts as an agonist for GPR39, not in the classical manner by directly stabilizing an active conformation of the transmembrane domain, but instead by binding to His17 and His19 in the extracellular domain. PMID: 18588883

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed in many tissues, including the stomach, intestine and hypothalamus.
  • 數據庫鏈接：

    HGNC: 4496

    OMIM: 602886

    KEGG: hsa:2863

    STRING: 9606.ENSP00000327417

    UniGene: Hs.432395



主站蜘蛛池模板： 欧美色欧美亚洲高清在线观看| 亂倫近親相姦中文字幕| 久久九九av免费精品| 一区二区三区四区在线 | 中国| 久久无码中文字幕免费影院| 成人免费毛片内射美女-百度| 国产丝袜美女| 97人妻人人揉人人躁人人| 午夜福利理论片高清在线| 免费毛片手机在线播放| 成人国产精品秘片多多| 亚洲欧美在线观看| 性按摩xxxx在线观看| 中文午夜乱理片无码| 先锋影音人妻啪啪va资源网站| 夜夜欢天天干| 中文字幕乱码中文乱码51精品| 国产美女嘘嘘嘘嘘嘘| 国产女厕所盗摄老师厕所嘘嘘| 国产av一区二区三区日韩| 成人性生交大片免费看vr| 伊人色综合久久天天网| 蜜桃麻豆www久久国产sex| 亚洲丰满熟女一区二区v| 99精品国产兔费观看久久99| 2020最新国产高清毛片| 国产综合18久久久久久| 亚洲色成人网站www永久| 日本体内she精高潮| 四虎影视88aa久久人妻| 欧美老肥妇多毛xxxxx| 久久久久国产a免费观看rela| 亚洲性无码av中文字幕| 先锋影音av资源站av| 在线精品自偷自拍无码| 全球av集中精品导航福利| 99re久久资源最新地址| 中日韩产精品1卡二卡三卡| 天堂在线最新版资源www中文| 97人妻无码一区二区精品免费| 国精产品69永久中国有限|