在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GPR39 Antibody

  • 中文名稱:
    GPR39兔多克隆抗體
  • 貨號:
    CSB-PA009812LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA009812LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA009812LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GPR39 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GPR39; G-protein coupled receptor 39
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human G-protein coupled receptor 39 protein (345-453AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,GPR39 Antibody (CSB-PA009812LA01HU),的標記方式是Non-conjugated。對于GPR39 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA009812LB01HU GPR39 Antibody, HRP conjugated ELISA
    FITC CSB-PA009812LC01HU GPR39 Antibody, FITC conjugated
    Biotin CSB-PA009812LD01HU GPR39 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death.
  • 基因功能參考文獻:
    1. data indicate that Zn(2+) acting via ZnR/GPR39 has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets. PMID: 28093242
    2. G protein-coupled receptor 39 (ZnR/GPR39) was shown to regulate the activity of ion transport mechanisms that are essential for the physiological function of epithelial and neuronal cells [Review]. PMID: 29389900
    3. Data suggest that expression of GPR39 undergoes Rho kinase-dependent desensitization following activation by zinc. PMID: 28619258
    4. This study demonstrated that zinc upregulates PKCzeta by activating GPR39 to enhance the abundance of ZO-1, thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells. PMID: 28515165
    5. obestatin/GPR39 system in the pathogenesis and/or clinical outcome of human gastric adenocarcinomas and highlight the potential usefulness of GPR39 as a prognostic marker in gastric cancer. PMID: 26716511
    6. Chronic administration of many antidepressants induces GPR39 up-regulation, which suggests that the Zn(2+)-sensing receptor may be considered as a new target for drug development in the field of depression. PMID: 25490458
    7. Taken together, our results provided a novel regulatory mechanism for GPR39-1b in NTRS1 signaling. PMID: 24512471
    8. ZnR/GPR39-dependent expression of tight junctional proteins, thereby leading to formation of a sealed intestinal epithelial barrier. PMID: 24967969
    9. Data suggests alterations (down-regulation) of the GPR39 receptor and involvement of CREB-BDNF pathway, possibly triggered by GPR39, as a new pathomechanism of depression PMID: 24333148
    10. Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein S100A4 that is linked to invasion of prostate cancer cells. PMID: 24264723
    11. GPR39 was present in thyroid autoimmune disease, non-toxic nodular goiter and toxic nodular goiter at band p51(kDa). PMID: 23485550
    12. ZnR/GPR39 is tuned to sense physiologically relevant changes in extracellular pH that regulate ZnR-dependent signaling and ion transport activity PMID: 22879599
    13. GPR39 activation increased the expression of the anti-apoptotic protein clusterin in butyrate-treated cells. GPR39 mediates Zn2+-dependent cell growth. PMID: 22545109
    14. GPR39 plays an important tumorigenic role in the development and progression of esophageal squamous cell carcinoma. PMID: 21352519
    15. extracellular Zn(2+), either applied or released following injury, activates ZnR/GPR39 to promote signaling leading to epithelial repair PMID: 20522546
    16. Data show that Phe-V:13 can serve as an aromatic lock for the proposed active conformation of the Trp-VI:13 rotameric switch, being involved in the global movement of TM-V and TM-VI in 7TM receptor activation. PMID: 19920139
    17. GPR39 is probably not the obestatin receptor PMID: 16959833
    18. could activate GPR39 by high concentrations of Zn(2+), demonstrating cell surface expression of a functional receptor that could elicit a Ca(2+) response. PMID: 17054911
    19. GPR39 functions as a Gq-coupled Zn2+-sensing receptor PMID: 17885920
    20. GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor PMID: 18180304
    21. It is proposed that Zn2+ acts as an agonist for GPR39, not in the classical manner by directly stabilizing an active conformation of the transmembrane domain, but instead by binding to His17 and His19 in the extracellular domain. PMID: 18588883

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed in many tissues, including the stomach, intestine and hypothalamus.
  • 數據庫鏈接:

    HGNC: 4496

    OMIM: 602886

    KEGG: hsa:2863

    STRING: 9606.ENSP00000327417

    UniGene: Hs.432395



主站蜘蛛池模板: 国产人妻精品久久久久野外| 无码国产一区二区三区四区| 少妇爽到呻吟的视频| 国产a v高清一区二区三区| 人人入人人爱| 无码人妻精品一区二区蜜桃百度| 国产在线精品无码二区| 任我橹这里只有精品 在线视频| 人成午夜免费视频无码| 97碰碰碰人妻无码视频| 人与禽性视频77777| 日本久久久久久久久久加勒比| 福利姬国产精品一区在线| 欧美一进一出抽搐大尺度视频| 很色很爽很黄裸乳视频| 国内精品乱码卡一卡2卡| 免费无遮挡无码视频在线观看| 99久久久国产精品免费蜜臀| 曰韩欧美群交p片内射| 国产综合有码无码中文字幕| 精产一二三产区m553| 对白脏话肉麻粗话av| 性欧美疯狂xxxxbbbb| 中文字幕漂亮人妻熟睡中被公侵犯| av无码免费岛国动作片不卡| 丰满人妻妇伦又伦精品国产| 成人高潮视频在线观看| 人人爽久久久噜人人看| 日韩一区精品视频一区二区| 精品少妇人妻av一区二区三区| 久久久橹橹橹久久久久高清| 在线成 人av影院| 国产一线二线三线女| 国产真实交换配乱婬95视频| 一本无码中文字幕在线观| 精品国产乱码久久久久久口爆| 中文在线最新版天堂| 国产精品内射视频免费| 成人奭片免费观看| 欧美激情第1页| 久久久久无码精品国产人妻无码|