在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human G-protein coupled receptor 183 (GPR183), partial

  • 中文名稱:
    人GPR183重組蛋白
  • 貨號:
    CSB-YP009792HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GPR183重組蛋白
  • 貨號:
    CSB-EP009792HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人GPR183重組蛋白
  • 貨號:
    CSB-EP009792HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GPR183重組蛋白
  • 貨號:
    CSB-BP009792HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GPR183重組蛋白
  • 貨號:
    CSB-MP009792HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    GPR183; EBI2; G-protein coupled receptor 183; Epstein-Barr virus-induced G-protein coupled receptor 2; EBV-induced G-protein coupled receptor 2; hEBI2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5. Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand. Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand. Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels. Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages. Promotes osteoclast precursor migration to bone surfaces. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).
  • 基因功能參考文獻:
    1. These data suggest a significant role for EBI2 in human CD4(+) T cell migration, notably in patients with multiple sclerosis. PMID: 28052250
    2. Studies provide evidence that EBI2 and oxysterols are important players not only in the immune system but also in the central nervous system. Proper functioning of the EBI2/oxysterol system seems crucial for healthy physiology and prevention of the onset or progression of several neurodegenerative diseases. [review] PMID: 26898310
    3. Human EBI2 (GPR183) expression in mice leads to an abnormally expanded CD5+ B1a B-cell subset and chronic lymphocytic leukemia-like B-cell malignancies. PMID: 28003273
    4. On ligand engagement, EBI2 typically signals via inhibitory G-protein subunit alpha to induce intracellular calcium mobilization, mitogen-activated protein kinase (MAPK) activation, and cell proliferation. PMID: 28125291
    5. this study concludes that EBI2 expression is directly influenced by EBV infection and that BRRF1 is necessary and sufficient for EBI2 upregulation during infection. PMID: 27902324
    6. These results demonstrate a role for EBI2 in astrocyte function and suggest that modulation of this receptor may be beneficial in neuroinflammatory disorders. PMID: 25297897
    7. EBI2 is expressed in primary human monocytes and macrophages. PMID: 24480442
    8. Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. PMID: 23473835
    9. This model of ligand docking yields important structural insight into the molecular mechanisms mediating EBI2 function. PMID: 22930711
    10. Data indicate that EBI2 expression modulates CXCL13 binding affinity to CXCR5. PMID: 22913878
    11. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). PMID: 22875855
    12. REVIEW: functional properties and in vivo biology PMID: 21261596
    13. Based on the constitutive signaling and cellular expression pattern of EBI2, it is suggested that it may function in conjunction with BILF1 in the reprogramming of the cell during EBV infection PMID: 16540462
    14. Structural motifs of importance for the constitutive activity of EBI2: analysis of receptor activation in the absence of an agonist. PMID: 18628402

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain. Expressed in astrocytes.
  • 數據庫鏈接:

    HGNC: 3128

    OMIM: 605741

    KEGG: hsa:1880

    STRING: 9606.ENSP00000365596

    UniGene: Hs.784



主站蜘蛛池模板: 欧美精品videosex极品| 婷婷综合缴情亚洲| 一道本在线伊人蕉无码| 亚洲乱码中文字幕综合| 亚洲欧美在线人成最新| 香蕉啪视频在线观看视频久| 好爽好硬好深高潮视频456| 亚洲精品夜夜夜| 欧美激情乱人伦| 久久婷婷狠狠综合激情| 国产99视频精品免视看7| 麻豆av福利av久久av| 成年片色大黄全免费软件到 | 亚洲国产成人无码av在线| 熟女少妇内射日韩亚洲| 夜夜精品无码一区二区三区| 亚洲色无码中文字幕手机在线| 色一情一乱一伦麻豆| 亚洲精品电影院| 寂寞人妻瑜伽被教练日| 国产乱女乱子视频在线播放| 大肉大捧一进一出好爽mba| 丁香婷婷激情综合俺也去| 国产深夜福利视频在线| 国产一区二区三区免费观看在线 | 成在线人永久免费视频播放 | 无码动漫性爽xo视频在线观看 | 小sao货水好多真紧h无码视频| 精品国产免费第一区二区三区| 怡红院成永久免费人视频新的 | 天天摸天天摸天天天天看| 五十路熟妇高熟无码视频| 蜜芽久久人人超碰爱香蕉| 亚洲综合小说专区图片| 四虎成人国产精品永久在线| 亚洲乱妇老熟女爽到高潮的片| av中文字幕潮喷人妻系列| 成年女人看片永久免费视频| 无卡无码无免费毛片| 国产精品成人a区在线观看| 超清制服丝袜无码av福利网|