在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human G-protein coupled receptor 124 (GPR124), partial

  • 中文名稱:
    Recombinant Human G-protein coupled receptor 124(GPR124) ,partial
  • 貨號:
    CSB-YP857001HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human G-protein coupled receptor 124(GPR124) ,partial
  • 貨號:
    CSB-EP857001HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human G-protein coupled receptor 124(GPR124) ,partial
  • 貨號:
    CSB-EP857001HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human G-protein coupled receptor 124(GPR124) ,partial
  • 貨號:
    CSB-BP857001HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human G-protein coupled receptor 124(GPR124) ,partial
  • 貨號:
    CSB-MP857001HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    DKFZp434C211; DKFZp434J0911; FLJ14390; G protein coupled receptor 124; G-protein coupled receptor 124; GP124_HUMAN; GPR 124; Gpr124; KIAA1531; TEM 5; TEM5; Tumor endothelial marker 5; Tumor endothelial marker 5 precursor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
  • 基因功能參考文獻:
    1. Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 = dedicator of cytokinesis protein 1 180 kDa) PMID: 28600358
    2. Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib. PMID: 24582749
    3. Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase. PMID: 22013897
    4. TEM5 expression during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of proliferation in endothelial cells. PMID: 19853600
    5. Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans PMID: 16982628

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell projection, filopodium.
  • 蛋白家族:
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 組織特異性:
    Expressed in endothelial cells (at protein level). Abundantly expressed in heart, placenta, ovary, small intestine, and colon.
  • 數據庫鏈接:

    HGNC: 17849

    OMIM: 606823

    KEGG: hsa:25960

    STRING: 9606.ENSP00000406367

    UniGene: Hs.274136



主站蜘蛛池模板: 国产 高清 无码 在线播放| 国产精品成人av片免费看| 国产尤物精品自在拍视频首页| 国产又色又爽又黄又免费| 97精品人妻一区二区三区香蕉| 亚洲欧洲日本无在线码| 亚洲国产成人精品无码区花野真一| 免费无码成人av片在线| 日本污ww视频网站| 香蕉视频在线观看亚洲| 亚洲偷自拍国综合| 四虎影视无码永久免费| 夜色爽爽影院18禁妓女影院| 久久天天躁狠狠躁夜夜2020一| 久久www免费人成精品| 无码写真精品永久福利在线| 国产成人啪精品视频免费视频| 无码一区二区免费波多野播放搜索| 亚洲精品人成无码中文毛片| 欧美成人精品第一区二区三区| 亚洲天堂2017无码中文| 人人狠狠久久亚洲综合88| 884aa四虎影成人精品 | 国产亚洲精品视觉盛宴| 欧美精品一区二区蜜臀亚洲 | 久章草在线精品视频免费观看| 国产超碰女人任你爽| 久青青视频在线观看久| 亚洲精品字幕在线观看| 久久99亚洲网美利坚合众国| 亚洲 欧美 另类 制服 日韩| 一区二区三区在线 | 日| 宅女午夜福利免费视频| 色翁荡息又大又硬又粗又爽电影| 99在线精品一区二区三区 | 国内少妇高潮嗷嗷叫在线播放| 日本阿v网站在线观看中文| 久久久老熟女一区二区三区| 日本亚洲国产一区二区三区| 欧美 日韩 亚洲 精品二区| 欧美特级特黄aaaaaa在线看|