在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GPR124 Antibody

GPR124 Antibody

  • 中文名稱：
    GPR124兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008647
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DKFZp434C211 antibody; DKFZp434J0911 antibody; FLJ14390 antibody; G protein coupled receptor 124 antibody; G-protein coupled receptor 124 antibody; GP124_HUMAN antibody; GPR 124 antibody; Gpr124 antibody; KIAA1531 antibody; TEM 5 antibody; TEM5 antibody; Tumor endothelial marker 5 antibody; Tumor endothelial marker 5 precursor antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human GPR124.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 = dedicator of cytokinesis protein 1 180 kDa) PMID: 28600358
    2. Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib. PMID: 24582749
    3. Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase. PMID: 22013897
    4. TEM5 expression during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of proliferation in endothelial cells. PMID: 19853600
    5. Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans PMID: 16982628

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, filopodium.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 組織特異性：
    Expressed in endothelial cells (at protein level). Abundantly expressed in heart, placenta, ovary, small intestine, and colon.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17849

    OMIM: 606823

    KEGG: hsa:25960

    STRING: 9606.ENSP00000406367

    UniGene: Hs.274136



主站蜘蛛池模板： 人妻插b视频一区二区三区| 色欲久久人妻内射| 欧美性群另类交| 亚洲色大成影网站www永久| 日本熟妇人妻xxxx| 国产内射老熟女aaaa∵| 五月激激激综合网亚洲| 亚洲人成网站18禁止中文字幕| 精品成在人线av无码免费看| 国产精品一卡二卡三卡| 欧亚乱熟女一区二区三区在线 | 国产午夜精品一区二区三区老| 国内精品免费久久久久软件| 最新亚洲中文字幕在线观看| 99久久久无码国产精品9| 丁香色欲久久久久久综合网| 亚洲中文字幕av不卡无码| 精品久久久久中文字幕app| 亚洲人成电影网站色www| 内射少妇36p亚洲区| 国产精品69人妻无码久久| 欧美做受又硬又粗又大视频| 国产成人av无码精品| 在线观看免费视频污网站| 成人免费网站视频www| 一本一道久久a久久精品综合| 国产精品熟妇视频国产偷人| 久久久久国色av免费看图片| 精品国产自在现线电影| 精品深夜av无码一区二区老年| 中文字幕一区二区人妻电影| 粉嫩小泬视频无码视频软件| 久久国产精品久久久久久| 8天堂资源在线| 97久章草在线视频播放| 午夜福利av无码一区二区| 国偷自产av一区二区三区 | 中文字幕亚洲码在线观看| 国产亚洲精品aaaa片app| 天天爽夜夜爽人人爽从早干到睌| 亚洲综合久久一本伊一区|