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  4. Recombinant Human Fructose-1,6-bisphosphatase isozyme 2 (FBP2)

Recombinant Human Fructose-1,6-bisphosphatase isozyme 2 (FBP2)

  • 中文名稱：
    人FBP2重組蛋白
  • 貨號：
    CSB-YP008460HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FBP2重組蛋白
  • 貨號：
    CSB-EP008460HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FBP2重組蛋白
  • 貨號：
    CSB-EP008460HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FBP2重組蛋白
  • 貨號：
    CSB-BP008460HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FBP2重組蛋白
  • 貨號：
    CSB-MP008460HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    6-bisphosphatase isozyme 2; 6-bisphosphate 1-phosphohydrolase 2; D fructose 1 6 bisphosphate 1 phosphohydrolase 2; D-fructose-1; F16P2_HUMAN; FBP 2; fbp2; FBPase 2; FBPase; fructose 1 6 bisphosphatase 2; Fructose 1 6 bisphosphatase isozyme 2; Fructose-1; Hexosediphosphatase; MGC142192; Muscle FBPase; Muscle fructose bisphosphatase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-339
  • 氨基酸序列
    MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR KAGLAHLYGI AGSVNVTGDE VKKLDVLSNS LVINMVQSSY STCVLVSEEN KDAIITAKEK RGKYVVCFDP LDGSSNIDCL ASIGTIFAIY RKTSEDEPSE KDALQCGRNI VAAGYALYGS ATLVALSTGQ GVDLFMLDPA LGEFVLVEKD VKIKKKGKIY SLNEGYAKYF DAATTEYVQK KKFPEDGSAP YGARYVGSMV ADVHRTLVYG GIFLYPANQK SPKGKLRLLY ECNPVAYIIE QAGGLATTGT QPVLDVKPEA IHQRVPLILG SPEDVQEYLT CVQKNQAGS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
  • 基因功能參考文獻：
    1. Results demonstrate that truncation of the evolutionarily conserved N-terminal residues of FBP2 results in a loss of its mitochondria-protective functions. PMID: 24412565
    2. FBP2 does negatively regulate cell growth, and reduced expression of FBP2 may contribute to carcinogenesis for gastric cancer. PMID: 24063558
    3. The key role in strong AMP binding to muscle isozyme play K20, T177 and Q179. PMID: 16213487
    4. The existence of highly AMP-sensitive muscle-like FBPase, activity of which is regulated by metabolite-dependent interaction with aldolase enables the precise regulation of muscle energy expenditures. PMID: 18214967
  • 亞細胞定位：
    Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    FBPase class 1 family
  • 組織特異性：
    Expressed in skeletal muscle (at protein level).
  • 數據庫鏈接：

    HGNC: 3607

    OMIM: 603027

    KEGG: hsa:8789

    STRING: 9606.ENSP00000364486

    UniGene: Hs.61255



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