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  4. Recombinant Human Filaggrin-2 (FLG2), partial

Recombinant Human Filaggrin-2 (FLG2), partial

  • 中文名稱：
    人FLG2重組蛋白
  • 貨號：
    CSB-YP704740HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FLG2重組蛋白
  • 貨號：
    CSB-EP704740HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FLG2重組蛋白
  • 貨號：
    CSB-EP704740HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FLG2重組蛋白
  • 貨號：
    CSB-BP704740HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FLG2重組蛋白
  • 貨號：
    CSB-MP704740HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FLG2
  • Uniprot No.：
  • 別名：
    FILA2_HUMAN; Filaggrin-2; FLG-2; FLG2; Ifapsoriasin; Intermediate filament-associated and psoriasis-susceptibility protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.
  • 基因功能參考文獻(xiàn)：
    1. Levels of FLG, FLG2 and SPRR3 mRNAs and proteins were reduced in AD skin. PMID: 27304082
    2. results indicate that filaggrin-2 was expressed in the oral mucosa under certain pathological conditions ( lichen planus, leukokeratosis and leukoplakia), demonstrating that an aberrant protein expression, together with filaggrin, indicates the altered differentiation program including hyperkeratosis that occurs in these diseases. PMID: 26858109
    3. Data suggest that innate immunity of skin involves FLG2, which is expressed in high abundance in upper epidermis/eccrine sweat glands; C-terminal peptide fragments of FLG2 exhibit antimicrobial functions against replication of Pseudomonas aeruginosa. PMID: 26371476
    4. These findings suggest that filaggrin-2 may play an overlapping role with filaggrin in epithelial cornification; however, it may also have a partially distinct role in the molecular processes of cornification. PMID: 24813994
    5. In an African American cohort with Atopic dermatitis (AD), FLG2 mutations were associated with more persistent AD. PMID: 24184149
    6. calpain 1 is essential for the proteolytic processing of FLG2 and that deimination accelerates this process. PMID: 21531719
    7. FLG2 and filaggrin may have overlapping and perhaps synergistic roles in the formation of the epidermal barrier, protecting the skin from environmental insults and the escape of moisture by offering precursors of natural moisturizing factors PMID: 19384417
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 19601998

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  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasmic granule.
  • 蛋白家族：
    S100-fused protein family; S-100 family
  • 組織特異性：
    Expressed in skin, thymus, stomach and placenta, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, adrenal gland, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea. Weakly exp
  • 數(shù)據(jù)庫鏈接：

    HGNC: 33276

    OMIM: 616284

    KEGG: hsa:388698

    STRING: 9606.ENSP00000373370

    UniGene: Hs.156124



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