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  4. Recombinant Human Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2), partial

Recombinant Human Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2), partial

  • 中文名稱：
    人FLVCR2重組蛋白
  • 貨號：
    CSB-YP892364HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FLVCR2重組蛋白
  • 貨號：
    CSB-EP892364HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FLVCR2重組蛋白
  • 貨號：
    CSB-EP892364HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FLVCR2重組蛋白
  • 貨號：
    CSB-BP892364HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FLVCR2重組蛋白
  • 貨號：
    CSB-MP892364HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FLVCR2
  • Uniprot No.：
  • 別名：
    FLVCR2; C14orf58Feline leukemia virus subgroup C receptor-related protein 2; Calcium-chelate transporter; CCT
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.
  • 基因功能參考文獻：
    1. Mutations in FLVCR2 associated with Fowler syndrome and survival beyond infancy PMID: 25677735
    2. Mutations in FLVCR2 gene are responsible for Proliferative vasculopathy and Hydranencephaly-hydrocephaly syndrome. FLVCR2 transporter is gatekeeper for the controlled entry of calcium into cell, and involves the regulation of calcium metabolism. PMID: 25906927
    3. FLVCR2 mutation is associated with Hydranencephaly. PMID: 25131804
    4. High-throughput sequence data identified mutations and a large deletion in the FLVCR2 gene casuing lethal cerebral vasculopathy. PMID: 20690116
    5. Results report the cellular function of FLVCR2 as an importer of heme. PMID: 20823265
    6. Direct sequencing of candidate genes within the target interval in chromosome 14q24.3 revealed five different germline mutations in FLVCR2 in five families with Fowler syndrome. PMID: 20206334

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  • 相關疾病：
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family
  • 組織特異性：
    Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver and kidney. Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow). Found in acidophil cells o
  • 數據庫鏈接：

    HGNC: 20105

    OMIM: 225790

    KEGG: hsa:55640

    STRING: 9606.ENSP00000238667

    UniGene: Hs.509966



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