在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Fatty acid 2-hydroxylase (FA2H), partial

  • 中文名稱:
    人FA2H重組蛋白
  • 貨號:
    CSB-YP007937HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人FA2H重組蛋白
  • 貨號:
    CSB-EP007937HU1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人FA2H重組蛋白
  • 貨號:
    CSB-EP007937HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人FA2H重組蛋白
  • 貨號:
    CSB-BP007937HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人FA2H重組蛋白
  • 貨號:
    CSB-MP007937HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    FA2H
  • Uniprot No.:
  • 別名:
    FA2H; FAAH; FAXDC1; Fatty acid 2-hydroxylase; Fatty acid alpha-hydroxylase; Fatty acid hydroxylase domain-containing protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
  • 基因功能參考文獻:
    1. Novel mutations in FA2H in Arab patients with a clinical spectrum of neurodegeneration and hereditary spastic paraparesis were identified. PMID: 25496456
    2. Three novel mutations in Chinese patients significantly reduce FA2H enzyme activity leading to hereditary spastic paraplegia. PMID: 24359114
    3. Induced levels of PPARalpha may be involved in the Delta(9)-THC up-regulation of FA2H in MDA-MB-231 cells. PMID: 25291031
    4. One heterozygous deletion within 16q22.3-q23.1 including FA2H was observed in two siblings who share symptoms of autism and severe cognitive impairment, axial T2-FLAIR weighted MRI posterior periventricular white matter lesions. PMID: 24299421
    5. Identification of a novel triple heterozygous mutations in FA2H gene (c.968C>A; c.976G>A; c.688G>A) in a Chinese family with Hereditary Spastic Paraplegia Type 35. PMID: 23566484
    6. FA2H is a novel (9)-THC-regulated gene, and that (9)-THC induces differentiation signal(s) in poorly differentiated MDA-MB-231 cells. PMID: 23535410
    7. we report a novel mutation in FA2H gene in two sibs presenting with adult onset complicated spastic paraparesis and thin corpus callosum PMID: 22925154
    8. This study did not find any mutations in the FA2H gene in patients with neurodegeneration with brain iron accumulation. PMID: 22704260
    9. a novel homozygous c.270+3A>T mutation altered FA2H function led to a severe phenotype, with clinical features overlapping those in three FA2H-associated disorders PMID: 21592092
    10. The 2-hydroxylated sphingomyelin (SM) profiles were characterized in blood and fibroblasts from patients harboring a deleterious FA2H mutation. PMID: 21599921
    11. Mutations in FA2H are associated with hereditary spastic paraplegia. PMID: 20104589
    12. the human FA2H gene encodes a fatty acid 2-hydroxylase involved in the formation of myelin 2-hydroxy galactosylceramides and -sulfatides PMID: 15337768
    13. late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis. PMID: 17355976
    14. Mutations in FA2H are associated with leukodystrophy with spastic paraparesis and dystonia. PMID: 19068277

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Spastic paraplegia 35, autosomal recessive (SPG35)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Sterol desaturase family, SCS7 subfamily
  • 組織特異性:
    Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21197

    OMIM: 611026

    KEGG: hsa:79152

    STRING: 9606.ENSP00000219368

    UniGene: Hs.461329



主站蜘蛛池模板: 亚洲欧美国产精品久久| 国产亚洲日本精品无码| 免费观看女人高潮视频软件| 国产一区二区三区精品av| 亚洲欧洲日产国产 最新| 国产乱码一区二区三区爽爽爽| 色综合久久一区二区三区| 国产精品va在线观看无码| 国产女人爽的流水毛片| 久久三级中文欧大战字幕| 国产精品久久久久无码av1 | 亚洲伊人久久精品酒店| 亚洲国产精品第一区二区| 四房播播开心五月| 亚洲国产成人av网站| 久久精品娱乐亚洲领先| 亚洲a∨无码无在线观看| 久久先锋男人av资源网站| 亚洲精品成人久久电影网| 亚洲另类色区欧美日韩图片| 天堂а√在线中文在线最新版| 极品少妇被后入内射视| 亚洲精品国产精华液有哪些| 99在线 | 亚洲| 国产剧情无码播放在线看| 毛多水多www偷窥小便| 樱花影院电视剧免费| 一色屋精品视频在线观看免费 | 丰满熟妇人妻中文字幕| 婷婷丁香五月六月综合激情啪| 麻豆成人av不卡一二三区| 996热re视频精品视频这里| 久久精品中文无码资源站| 777yyy亚洲精品久久久| 青草青草视频2免费观看| 中文无码一区二区不卡αv| 欧美又粗又长又爽做受| 国产精品丝袜亚洲熟女| 伊人久久大香线蕉无码| 成在线人免费视频一区二区| 国产成人精品视频网站|