在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Fatty acid 2-hydroxylase (FA2H), partial

Recombinant Human Fatty acid 2-hydroxylase (FA2H), partial

  • 中文名稱：
    人FA2H重組蛋白
  • 貨號：
    CSB-YP007937HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FA2H重組蛋白
  • 貨號：
    CSB-EP007937HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FA2H重組蛋白
  • 貨號：
    CSB-EP007937HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FA2H重組蛋白
  • 貨號：
    CSB-BP007937HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FA2H重組蛋白
  • 貨號：
    CSB-MP007937HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FA2H
  • Uniprot No.：
  • 別名：
    FA2H; FAAH; FAXDC1; Fatty acid 2-hydroxylase; Fatty acid alpha-hydroxylase; Fatty acid hydroxylase domain-containing protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
  • 基因功能參考文獻：
    1. Novel mutations in FA2H in Arab patients with a clinical spectrum of neurodegeneration and hereditary spastic paraparesis were identified. PMID: 25496456
    2. Three novel mutations in Chinese patients significantly reduce FA2H enzyme activity leading to hereditary spastic paraplegia. PMID: 24359114
    3. Induced levels of PPARalpha may be involved in the Delta(9)-THC up-regulation of FA2H in MDA-MB-231 cells. PMID: 25291031
    4. One heterozygous deletion within 16q22.3-q23.1 including FA2H was observed in two siblings who share symptoms of autism and severe cognitive impairment, axial T2-FLAIR weighted MRI posterior periventricular white matter lesions. PMID: 24299421
    5. Identification of a novel triple heterozygous mutations in FA2H gene (c.968C>A; c.976G>A; c.688G>A) in a Chinese family with Hereditary Spastic Paraplegia Type 35. PMID: 23566484
    6. FA2H is a novel (9)-THC-regulated gene, and that (9)-THC induces differentiation signal(s) in poorly differentiated MDA-MB-231 cells. PMID: 23535410
    7. we report a novel mutation in FA2H gene in two sibs presenting with adult onset complicated spastic paraparesis and thin corpus callosum PMID: 22925154
    8. This study did not find any mutations in the FA2H gene in patients with neurodegeneration with brain iron accumulation. PMID: 22704260
    9. a novel homozygous c.270+3A>T mutation altered FA2H function led to a severe phenotype, with clinical features overlapping those in three FA2H-associated disorders PMID: 21592092
    10. The 2-hydroxylated sphingomyelin (SM) profiles were characterized in blood and fibroblasts from patients harboring a deleterious FA2H mutation. PMID: 21599921
    11. Mutations in FA2H are associated with hereditary spastic paraplegia. PMID: 20104589
    12. the human FA2H gene encodes a fatty acid 2-hydroxylase involved in the formation of myelin 2-hydroxy galactosylceramides and -sulfatides PMID: 15337768
    13. late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis. PMID: 17355976
    14. Mutations in FA2H are associated with leukodystrophy with spastic paraparesis and dystonia. PMID: 19068277

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Spastic paraplegia 35, autosomal recessive (SPG35)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sterol desaturase family, SCS7 subfamily
  • 組織特異性：
    Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21197

    OMIM: 611026

    KEGG: hsa:79152

    STRING: 9606.ENSP00000219368

    UniGene: Hs.461329



主站蜘蛛池模板： 午夜精品射精入后重之免费观看 | 日本精品人妻无码免费大全| 国产精品久久久久久久久鸭 | 日韩在线看片免费人成视频播放 | 妺妺窝人体色www在线| 天堂а√在线最新版中文| 少妇精品偷拍高潮少妇小说| 国产精品55夜色66夜色| 欧美午夜刺激影院| 成熟了的熟妇毛茸茸| 精品国产三级a在线观看| 一本色道久久东京热| 国产精品美女久久久久网站浪潮 | 337p日本欧洲亚洲大胆精筑| 亚洲精品欧美二区三区中文字幕| 欧美精品亚洲精品日韩传电影| 狠狠色噜噜狠狠狠777米奇小说| 99精品热在线在线观看视频| 久久久99精品成人片中文字幕| 国产一精品一av一免费| 日本精品久久久久中文字幕| 中文字幕无码人妻丝袜| 国产成人不卡无码免费视频| 国产成人午夜高潮毛片| 久久婷婷五月综合97色直播| 国产日韩在线视看高清视频手机 | 日韩国产成人无码av毛片蜜柚| 亚洲成av人片天堂网无码】| 男人j桶进女人p无遮挡免费观看| 亚洲国产成人久久一区二区三区| 日本国产网曝视频在线观看| 亚洲成_人网站图片| 中国内地毛片免费高清| 欧美又大又粗午夜剧场免费| 亚洲 日韩 国产 有码 不卡 | 极品尤物被啪到呻吟喷水| 国产熟妇疯狂4p交在线播放| 中文字幕精品亚洲无线码vr| 大陆极品少妇内射aaaaa| 免费看国产曰批40分钟| 日韩美女自卫慰黄网站|