在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Fanconi anemia-associated protein of 24 kDa (FAAP24)

Recombinant Human Fanconi anemia-associated protein of 24 kDa (FAAP24)

  • 中文名稱：
    人FAAP24重組蛋白
  • 貨號：
    CSB-YP866280HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FAAP24重組蛋白
  • 貨號：
    CSB-EP866280HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FAAP24重組蛋白
  • 貨號：
    CSB-EP866280HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FAAP24重組蛋白
  • 貨號：
    CSB-BP866280HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FAAP24重組蛋白
  • 貨號：
    CSB-MP866280HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FAAP24
  • Uniprot No.：
  • 別名：
    FAAP24; C19orf40Fanconi anemia core complex-associated protein 24; Fanconi anemia-associated protein of 24 kDa
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-215
  • 氨基酸序列
    MEKNPPDDTG PVHVPLGHIV ANEKWRGSQL AQEMQGKIKL IFEDGLTPDF YLSNRCCILY VTEADLVAGN GYRKRLVRVR NSNNLKGIVV VEKTRMSEQY FPALQKFTVL DLGMVLLPVA SQMEASCLVI QLVQEQTKEP SKNPLLGKKR ALLLSEPSLL RTVQQIPGVG KVKAPLLLQK FPSIQQLSNA SIGELEQVVG QAVAQQIHAF FTQPR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
  • 基因功能參考文獻：
    1. This is the first report of an FAAP24 loss of function mutation found in human patients with EBV-associated lymphoproliferation. PMID: 27473539
    2. These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation. PMID: 23999858
    3. Crystal structure of the FANCM-FAAP24 complex. PMID: 23932590
    4. Results show that the first HhH motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM-FAAP24 to chromatin. PMID: 24003026
    5. FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity. PMID: 23333308
    6. FAAP24 targets FANCM to structures that mimic intermediates formed during the replication/repair of damaged DNA. PMID: 17289582
    7. FAAP24 is dispensable for DNA binding and branch migration activity of FANCM. PMID: 18206976

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28467

    OMIM: 610884

    KEGG: hsa:91442

    STRING: 9606.ENSP00000466121

    UniGene: Hs.579899



主站蜘蛛池模板： 天天综合网久久综合免费人成| 国产精品免费一区二区三区四区| 国产一区二区精品久久| 精品国产你懂的在线观看| 亚洲日本乱码中文在线电影| 女人被强╳到高潮喷水在线观看| 国产精品久久久久久久久人妻| 一区三区不卡高清影视| 免费午夜福利不卡片在线| 欧美喷潮久久久xxxxx| 色噜噜狠狠色综合成人网| 国产av一区二区精品凹凸| 亚洲高清一区二区三区不卡| 久久国产一区二区三区| 精品一区二区三区无码免费视频| 日本一道一区二区视频| 美国特级a毛片免费网站| 国产精品厕所| 日本强好片久久久久久aaa | 免费观看国产小粉嫩喷水| 舌头伸进去搅动好爽视频| 国产精品无码人妻一区二区在线| 日日碰狠狠躁久久躁2023| 亚洲 欧美 清纯 校园 另类| 国产福利免费视频不卡| 女厕偷窥一区二区三区| 午夜影视啪啪免费体验区入口| 亚洲精品第一国产综合国服瑶| 欧美mv日韩mv国产网站| 免费观看又色又爽又黄的韩国 | 三级在线看中文字幕完整版| 亚洲aⅴ在线无码播放毛片一线天 吃奶摸下高潮60分钟免费视频 | av无码av在线a∨天堂app| 女人被狂c躁到高潮视频| 一本色道久久综合狠狠躁| 少妇被粗大的猛进出69影院 | 国产专区国产av| 首页 综合国产 亚洲 丝袜| 亚洲欧洲精品无码av| 国精产品一区一区三区mba下载| 高潮又爽又无遮挡又免费|