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  4. Recombinant Human FH1/FH2 domain-containing protein 3 (FHOD3), partial

Recombinant Human FH1/FH2 domain-containing protein 3 (FHOD3), partial

  • 中文名稱：
    人FHOD3重組蛋白
  • 貨號：
    CSB-YP651981HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FHOD3重組蛋白
  • 貨號：
    CSB-EP651981HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FHOD3重組蛋白
  • 貨號：
    CSB-EP651981HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FHOD3重組蛋白
  • 貨號：
    CSB-BP651981HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FHOD3重組蛋白
  • 貨號：
    CSB-MP651981HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FHOD3
  • Uniprot No.：
  • 別名：
    FLJ22717; Formactin2; FH1/FH2 domain containing protein 3; FH1/FH2 domain-containing protein 3; Fhod3; FHOD3_HUMAN; FHOS2; FLJ22297; Formactin-2; Formin homolog overexpressed in spleen 2; Formin homology 2 domain containing 3; hFHOS2; KIAA1695; mKIAA1695
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Actin-organizing protein that may cause stress fiber formation together with cell elongation. Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.
  • 基因功能參考文獻：
    1. FHOD3 played a role in glioma linear migration. PMID: 26912794
    2. Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo. PMID: 26370503
    3. DCM-associated FHOD3 variant may cause DCM by interfering with actin filament assembly. PMID: 24088304
    4. FHOD variants is with hypertrophic cardiomyopathy. PMID: 23255317
    5. C-terminal phosphorylation by ROCK1 is sufficient for FHOD3 activation as evidenced by an increase in F-actin in HeLa cells. PMID: 23052206
    6. Single nucleotide polymorphism in FHOD3 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
    7. actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells. PMID: 19706596

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton.; [Isoform 4]: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.
  • 蛋白家族：
    Formin homology family
  • 組織特異性：
    Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein l
  • 數據庫鏈接：

    HGNC: 26178

    OMIM: 609691

    KEGG: hsa:80206

    STRING: 9606.ENSP00000257209

    UniGene: Hs.436636



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