Recombinant Human FGFR1 oncogene partner 2 (FGFR1OP2)

中文名稱：

人FGFR1OP2重組蛋白
貨號(hào)：

CSB-YP008644HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人FGFR1OP2重組蛋白
貨號(hào)：

CSB-EP008644HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人FGFR1OP2重組蛋白
貨號(hào)：

CSB-EP008644HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FGFR1OP2重組蛋白
貨號(hào)：

CSB-BP008644HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人FGFR1OP2重組蛋白
貨號(hào)：

CSB-MP008644HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

FGFR1OP2
Uniprot No.：

Q9NVK5
別名：

DKFZp564O1863; FGFR1 oncogene partner 2; FGFR1OP2; FGOP2_HUMAN; Fibroblast growth factor receptor 1 oncogene partner 2; HSPC123; HSPC123 like; WIT3.0; Wound inducible transcript 3.0
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-253
氨基酸序列

MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALNKRV EAMKQYQEEI QELNEVARHR PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI MSKYREQMFR LLMASKKDDP GIIMKLKEQH SKIDMVHRNK SEGFFLDASR HILEAPQHGL ERRHLEANQN ELQAHVDQIT EMAAVMRKAI EIDEQQGCKE QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS ALVTNSDLSL RKS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May be involved in wound healing pathway.
基因功能參考文獻(xiàn)：
1. The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulous mandible whereas the patients with that of rs840869 are not associated in Korean population. PMID: 22880093
2. patients with the minor allele of rs840869 or rs859024 of FGFR1OP2 were associated with excessive atrophy of edentulous mandible PMID: 21283824
3. FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure. PMID: 19959814
4. FGFR1OP2 is a new FGFR1 fusion gene involving a chromosomes 12X8 translocation in a 8p11 myeloproliferative syndrome patient. PMID: 15034873
相關(guān)疾病：

A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

SIKE family
組織特異性：

Expressed in bone marrow, spleen and thymus.
數(shù)據(jù)庫鏈接：

HGNC: 23098

OMIM: 608858

KEGG: hsa:26127

STRING: 9606.ENSP00000229395

UniGene: Hs.591162