在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human F-box only protein 4 (FBXO4)

  • 中文名稱:
    人FBXO4重組蛋白
  • 貨號:
    CSB-YP891538HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人FBXO4重組蛋白
  • 貨號:
    CSB-EP891538HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人FBXO4重組蛋白
  • 貨號:
    CSB-BP891538HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人FBXO4重組蛋白
  • 貨號:
    CSB-MP891538HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    DKFZp547N213; F box only protein 4 ; F box protein 4; F box protein Fbx4; F-box only protein 4; FBX4; FBX4_HUMAN; FBXO 4; FBXO4; FLJ10141
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-387
  • 氨基酸序列
    MAGSEPRSGT NSPPPPFSDW GRLEAAILSG WKTFWQSVSK ERVARTTSRE EVDEAASTLT RLPIDVQLYI LSFLSPHDLC QLGSTNHYWN ETVRDPILWR YFLLRDLPSW SSVDWKSLPD LEILKKPISE VTDGAFFDYM AVYRMCCPYT RRASKSSRPM YGAVTSFLHS LIIQNEPRFA MFGPGLEELN TSLVLSLMSS EELCPTAGLP QRQIDGIGSG VNFQLNNQHK FNILILYSTT RKERDRAREE HTSAVNKMFS RHNEGDDQQG SRYSVIPQIQ KVCEVVDGFI YVANAEAHKR HEWQDEFSHI MAMTDPAFGS SGRPLLVLSC ISQGDVKRMP CFYLAHELHL NLLNHPWLVQ DTEAETLTGF LNGIEWILEE VESKRAR
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.
  • 基因功能參考文獻(xiàn):
    1. in head and neck squamous cell carcinoma, fragile X mental retardation syndrome related protein 1 (Fxr1) overexpression correlates with reduced F-box protein 4 (Fbxo4) levels. PMID: 29142209
    2. FBXO4 is the E3 ubiquitin ligase to interact with and promote Mcl-1 ubiquitination and degradation. PMID: 28776569
    3. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 expression in human cancers. PMID: 24704453
    4. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation. PMID: 24019069
    5. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function. PMID: 21242966
    6. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein. PMID: 20181953
    7. results reveal an atypical small GTPase domain within Fbx4 as a substrate-binding motif for SCF(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 in telomere homeostasis control PMID: 20159592
    8. Fbx4 is a central regulator of Pin2/TRF1 protein abundance and alterations in the stability of Pin2/TRF1 can have a dramatic impact on telomere length PMID: 16275645
    9. SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1. PMID: 17081987
    10. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. PMID: 18598945

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13583

    OMIM: 609090

    KEGG: hsa:26272

    STRING: 9606.ENSP00000281623

    UniGene: Hs.165575



主站蜘蛛池模板: 国产二级一片内射视频播放| 无码人妻丰满熟妇啪啪欧美| 少妇熟女高潮流白浆| 欧美一性一乱一交一视频| 超碰97人人做人人爱亚洲尤物| 精品无码国产自产在线观看水浒传 | 精品乱码一区内射人妻无码| 国产精成人品| 成人亚洲欧美日韩在线观看| 中文字幕亚洲码在线观看| 亚洲精品卡一卡三卡四卡乱码 | 亚洲熟妇国产熟妇肥婆| 亚洲熟妇中文字幕日产无码| 少妇高潮无套内谢麻豆传| 欧美真人做爰在线观看| 久久婷婷五月综合色99啪| 欧美又粗又大又硬又长又爽视频| 免费毛片在线看片免费丝瓜视频 | 在线看片免费人成视频福利| 国产高清视频色拍| 熟女肥臀白浆大屁股一区二区| 好吊视频一区二区三区| 国产 高潮 抽搐 正在播放| 无线乱码一二三区免费看| 伊人成色综合网| 国产精品久久久久不卡绿巨人| 亚洲欧美日韩在线资源观看| 少妇大叫太大太爽受不了| 亚洲精品久久无码av片| 老子午夜理论影院理论| 图片区小说区亚洲欧美自拍| 久久丫精品忘忧草西安产品| 图片区小说区激情区偷拍区 | 永久免费精品精品永久-夜色| 热の综合热の国产热の潮在线| 99久久精品免费看国产| 国产成人精品男人的天堂| 国产一区二区三区在线视頻| 大又大又粗又硬又爽少妇毛片| 亚洲熟妇av日韩熟妇在线| 国产漂亮白嫩美女在线观看|